ABSTRACT We developed and tested the Bayesian multiple comparison correction method for Bayesian voxelwise second-level fMRI analysis with R. The performance of the developed method was tested with simulation and real image datasets. First, we compared false alarm and hit rates, which were used as proxies for selectivity and sensitivity, respectively, between Bayesian and classical inference methods. For the comparison, we created simulated images, added noise to the created images, and analyzed the noise-added images while applying Bayesian and classical multiple comparison correction methods. Second, we analyzed five real image datasets to examine how our Bayesian method worked in realistic settings. When the performance assessment was conducted, the Bayesian correction method demonstrated good sensitivity (hit rate ≥ 75%) and acceptable selectivity (false alarm rate < 10%) when N ≥ 8. Furthermore, the Bayesian correction method showed better sensitivity compared with the classical correction method while maintaining the aforementioned acceptable selectivity.

ABSTRACT The inferior parietal cortex (IPC) is involved in different cognitive functions including language. In line with the correlated transmitter receptor-based organization of the IPC, this part of the brain is parcellated into the rostral, the middle and the caudal clusters; however, the tripartite organization of the IPC has not been addressed in studies with a focus on cognitive control of language. Using multiband EPI, in this study we investigated how the rostral IPC contributes to this executive function in bilinguals. In doing so, we focused on the functional connectivity patterns of this part of the cortex with other brain areas in a context characterized with language engagement and disengagement that recruits the neural mechanisms of cognitive control. We found that in switching to L2, which was cognitively less demanding, the right rostral IPC had positive functional connectivity with the anterior division of the cingulate gyrus and the precentral gyrus. However, in switching to L1, which was cognitively more demanding, the right IPC rostral cluster had negative functional coupling with the postcentral gyrus and the precuneus cortex and positive connectivity with the posterior lobe of the cerebellum. In this condition, the left IPC rostral cluster had negative functional coupling with the superior frontal gyrus and the precuneus cortex. Thus, the connectivity patterns of the rostral IPC was influenced by the cognitive demand in an asymmetrical and lateral manner during cognitive control of language.

ABSTRACTSelective attention allows us to prioritize the processing of relevant information and filter out irrelevant information. Human functional neuroimaging and lesion-based studies have highlighted the fronto-parietal dorsal attention network (DAN) as an important network in this process. In this study, we investigated the role of the DAN in distracter suppression by dynamically modifying the priority of visual information (target > high priority distracter > low priority distracter) based on features only. To this end, we collected fMRI data in 24 healthy subjects, who performed a feature-based variant of the sustained attention to response task. Participants had to select one or attend two stream(s) of overlapping digits that differed in color and respond to each digit in the task-relevant stream(s) except to a single non-target digit. Results showed higher DAN activity when a target was co-presented with a high versus low priority distracter. Furthermore, higher DAN activity was observed when selectively attending one (target + high/low priority distracter) versus simultaneously attending two (target + target) stream(s) of digits. In conclusion, our study highlights the contribution of the DAN in the feature-based suppression of task-irrelevant information.

ABSTRACT Movement-related theta oscillations in rodent hippocampus coordinate ‘forward sweeps’ of location-specific neural activity that could be used to evaluate spatial trajectories online. This raises the possibility that increases in human hippocampal theta power accompany the evaluation of upcoming spatial choices. To test this hypothesis, we measured neural oscillations during a spatial planning task that closely resembles a perceptual decision-making paradigm. In this task, participants searched visually for the shortest path between a start and goal location in novel mazes that contained multiple choice points, and were subsequently asked to make a spatial decision at one of those choice points. We observed ~4–8 Hz hippocampal/medial temporal lobe theta power increases specific to sequential planning that were negatively correlated with subsequent decision speed, where decision speed was inversely correlated with choice accuracy. These results implicate the hippocampal theta rhythm in decision tree search during planning in novel environments.

ABSTRACT The auditory system is tuned to detect rhythmic regularities in the environment which can occur on different timescales. Event-related potentials such as mismatch negativity (MMN) and P3b are thought to index local and global deviance, respectively. However, it is not clear how these hierarchical levels interact and to what extent attention modulates this interaction. In this EEG study with 17 healthy young adults, we used a hierarchical oddball paradigm with local (sequence-level) and global (block-level) violations in attended and unattended conditions. Amplitude of N2 and P3b were analyzed in a 2*2*2 factorial model (local status, global status, attention condition). We found a significant interaction between the local and global status on the N2 amplitude, while there was no significant three-way interaction with attention, together demonstrating that lower-level prediction error is modulated by detection of higher-order regularity but expressed independently of attention. By contrast, higher-level prediction error, indexed by P3b, was sensitive to global regularity violations if the auditory stream was attended. The results demonstrate the capacity of our auditory perception to preattentively resolve conflicts between different levels of predictive hierarchy even across longer time intervals as indexed by MMN modulation, while P3b represents a different, attention-dependent system.

ABSTRACTCooper, Greve, and Henson (this issue) conclude that hippocampal-independent learning, as operationalised by ‘fast mapping’ (FM), is unlikely to facilitate learning in adults. We provide evidence from patients with Developmental Amnesia (DA), who acquire language and semantic knowledge despite early hippocampal pathology. We administered an FM paradigm to three patients with DA and controls. Patients showed no benefit of FM compared to explicit encoding. These data support the conclusion that FM is unlikely to facilitate learning in amnesia, regardless of age at onset. Hippocampal-independent learning may be possible in adults with DA, but such learning requires a prolonged consolidation period.

ABSTRACTStudies of fast mapping (FM) in adults have included both positive results and failures to replicate. I argue that although conflicting studies warrant caution, FM findings are nonetheless promising and intriguing. I separate the issue into distinct questions: whether FM has hippocampal independence, and whether it has unique cognitive consequences. I clarify some misunderstandings and identify limitations that may contribute to failures to find learning from FM in some amnesic patients. Finally, I argue that the array of behavioral findings in healthy adults is consistent with computational and neural models.

ABSTRACTThe accumulation of similar interfering experiences hampers our ability to retrieve information. To reduce interference, pattern separation allows the separation of similar memories and build detailed memory representations that are less easily confused. To investigate mnemonic interference, previous research has used a mnemonic discrimination paradigm in which the participants have to mnemonically discriminate between two similar items. Unique from previous studies, electrophysiological brain activity was recorded while 26 healthy participants performed a visual mnemonic discrimination task in which we parametrically manipulated the number of studied exemplars from each category. According to our expectations, as the number of exemplars from the same object category increased, participants were less able to discriminate between old and similar presented items. A ‘parietal’ old/new effect in a temporal window associated with recollection was observed when interference was higher. Increasing the number of exemplars presented also modulated the ERP amplitude in a temporal window associated with familiarity.

ABSTRACTBrain stimulation technologies have seen increasing application in basic science investigations, specifically toward the goal of improving memory function. However, proposals concerning the neural mechanisms underlying cognitive enhancement often rely on simplified notions of excitation. As a result, most applications examining the effects of transcranial magnetic stimulation (TMS) on functional neuroimaging measures have been limited to univariate analyses of brain activity. We present here analyses using representational similarity analysis (RSA) and encoding-retrieval similarity (ERS) analysis to quantify the effect of TMS on memory representations. To test whether an increase in local excitability in PFC can have measurable influences on upstream representations in earlier temporal memory regions, we compared 1 and 5Hz stimulation to the left dorsolateral PFC (DLPFC). We found that 5Hz rTMS, relative to 1Hz, had multiple effects on neural representations: 1) greater representational similarity during both encoding and retrieval in ventral stream regions, 2) greater ERS in the hippocampus, and, critically, 3) increasing ERS in MTL was correlated with increasing univariate activity in DLPFC, and greater functional connectivity for hits than misses between these regions. These results provide the first evidence of rTMS modulating semantic representations and strengthen the idea that rTMS may affect the reinstatement of previously experienced events in upstream regions.

ABSTRACTAlcohol and other pharmacologically similar sedatives (i.e., GABAA positive allosteric modulators or PAMs) impair the encoding of new episodic memories but retroactively facilitate the consolidation of recently encoded memories. These effects are consistent for recollection (i.e., the retrieval of details) but some mixed results have been reported for familiarity (i.e., a feeling of knowing a stimulus was presented). Here, with dual-process models, we reanalyzed prior work testing the effects of GABAA PAMs at encoding or consolidation. Contrary to previous conclusions, we show that GABAA PAMs at encoding consistently impair both recollection and familiarity when an independence correction is applied to familiarity-based responses. These findings were further confirmed and extended in a dual-process signal detection analysis of a recent study on the effects of alcohol during encoding or consolidation: Alcohol at encoding impaired both recollection and familiarity, whereas alcohol at consolidation enhanced both recollection and familiarity. These findings speak to the ability of alcohol and other GABAA PAMs to induce ‘blackouts,’ highlighting the importance of dual-process approaches when analyzing drug manipulations at different phases of episodic memory.