Introduction: The Cannabis sativa Linn plant is an excellent source of fiber, containing important phytochemical constituents, such as Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD), which have been found to be effective in the treatment of various ailments, such as neurodegenerative diseases, epilepsy, pain, inflammation, insomnia, etc. As a result, various drug dosage forms, such as tablets, capsules, transdermal patches, and liquid formulations, have been developed, and many are under clinical investigation, while many formulations are still in development to benefit human health. Method: This review was conducted by analyzing articles on Cannabis sativa published in the last ten years from ScienceDirect, Scopus, PubMed, Web of Science, and SciFinder. Recent papers explore patents on different Cannabis sativa formulations and their diverse applications. Result: The existing literature underscores the pivotal role played by Cannabis sativa within the realm of pharmaceuticals. It has emerged as a promising candidate in various domains, including neurodegenerative diseases, diabetes management, antimicrobial resistance, antidepressant treatments, antiviral therapies, cancer treatment, hypertension management, inflammation reduction, and antioxidant applications. Conclusion: This review discusses the origin of the species, its history, marketed formulations, clinically investigated drugs, updated patents, and the various therapeutic applications of cannabis in different diseases. It also highlights its efficacy and safe use for human health.

Introduction: The antioxidant fraction of Stevia rebaudiana has important antidiabetic potential, is poorly soluble, and has low stability, which makes its applicability difficult. Materials and Methods: In this study, Stevia's fraction was obtained, characterized by Ultra-high-performance liquid chromatography coupled with mass spectrometry (UHPLCMS/ MS), and microencapsulated with maltodextrin (MDF), gum arabic (GAF), whey protein + maltodextrin (MDWF), and whey protein + gum arabic (GAWF). Then, the following parameters were evaluated: stability and antioxidant capacity over 30 days, physicochemical characteristics, preservation of bioactive compounds by digestion, and in vitro antidiabetic activity. Results and Discussion: The microcapsule with gum arabic showed better microencapsulation efficiency, while its version with maltodextrin provided increased solubility. Microencapsulation reduced the humidity and water activity in the microcapsules, except for the microcapsules containing gum arabic. The combination of maltodextrin and whey protein showed greater luminosity and a whiter powder. The microcapsules with maltodextrin and its mixture with gum arabic kept the phenolic compounds stable for 30 days. The microencapsulation with whey protein increased the antioxidant activity after 15 days of the process and during in vitro digestion. All samples showed 96% inhibition of the α-glucosidase enzyme, and only the microcapsule with maltodextrin inhibited α-amylase (58%). Conclusion: This study showed paramount results so that Antioxidant Stevia Fraction (ASF) can effectively be an adjuvant product to prevent and treat diabetes.

Background: Bioactive compounds were isolated, characterized, but their efficacy, potency and mechanism of action to treat/prevent several diseases yet to defined. The present review provides the insight on the activity of nature derived bioactive compounds therapeutic potential against communicable and non-communicable disease by using in silico approaches such as structure-based virtual screening, ligand-based virtual screening, quantitative structure activity relationships (QSAR) modeling, network-based methods (molecular networking) which could be a breakthrough for the novel bioactive drug development of personalized medicine toward the numerous diseases. Methods: This study conducted a thorough literature search on various computational tools used for elucidation of bioactive compounds against communicable and non-communicable diseases. The search was performed using multiple search engines and the main keywords, and only English publications (Web of science, Pub med, Science direct etc.) published up to 2023 were included. Results: The research presented the various computational tools used for elucidation of bioactive compounds against communicable and non-communicable diseases and possible mechanism of action of lead compounds. It also gives the brief how computational tools might be used in future for personalized medicine development with recently conducted studies outcome. Conclusion: The present review concludes that computational tools help to narrow down the hit compounds via computational tools (virtual screening) and in short period of the time millions of bioactive compounds could be investigated for their therapeutic potential. These review emphasize the potential impact of computational approaches on drug development and personalized medicine.

Nowadays, cancer treatment is currently limited to surgery, chemotherapy, and radiation, which carry the risk of damaging the normal tissue of the body and incomplete removal of the cancerous cells from the body. Thus, the Nano technique offers a great means to target therapies directly on cancerous cells and neoplasm. Moreover, because nano-based formulations of polyphenolic curcumin show a major effect on cancer and tumour cells, nanoparticles have a tendency to overcome the hydrophobic nature of curcumin to improve its stability and bioavailability in vitro and in vivo. It is apparent from the studies that Curcumin has shown anticancer effects by regulating various immunomodulators, which include cytokines, reactive oxygen species, and cyclooxygenase-2 (COX-2). It also takes part in the downregulation of growth factors, protein kinases, oncogenic molecules, and various signalling pathways, such as nuclear factor kappalight- chain enhancer of activated B cells (NF-κB), c-Jun N-terminal kinase (JNK), and signal transducer and activator of transcription 3 (STAT3) signalling. According to recent studies and clinical trials, nano curcumin shows a major effect on cancerous cells. In this article, the authors summarised the mechanism of nano curcumin in various metastatic cancers and the most recent clinical trials performed.

Skin cancer has become the fifth most frequently reported form of cancer worldwide, imposing significant economic and public health challenges. Over the course of the last ten years, there has been a significant increase in the application of Nanoparticles (NPs) as a method of therapeutic administration to target skin cancer. The information has been gathered from many online databases, such as Scopus, Pubmed, Science Direct, and Web of Science, among others. An analysis of research articles that focused on the therapeutic effect of nanoformulations on skin cancer was included as part of the criteria for selecting the study. Nanoparticles have the potential to change the pharmacokinetics of the drug, increase the drug’s half-life by lowering immunogenicity, increase its bioavailability, decrease drug metabolism, and improve the solubility of poorly water-soluble drugs. The distribution of NP-based treatments to the skin requires special consideration due to the fact that the skin acts as both a physical and immunologic barrier. In addition, specialized technologies must take into consideration not only the target but also the channel of administration in order to be effective. The purpose of this review article was to provide an overview of many types of NPs, address the current landscape of NPs for skin cancer prevention and treatment, and provide a description of the application of NP-based technologies for drug delivery targeting the skin.

Abstract: The family Lamiaceae includes the genus Lavandula, which is widely cultivated throughout the Mediterranean region, including France, Spain, and Italy. The plant forms dense clumps that are roughly 40-60 cm tall. The reference genome for "Jingxun 2," an excellent cultivar of Lavender (Lavandula angustifolia) was created by a research team in China. Lavandula which contains tannins, phytosterols, coumarins, herniarins, ursolic acid, sugars, valeric acid, glycolic acid, coumaric acid, anthocyanins, minerals, and essential oils. Lavender oil can also help with many kinds of health problems because it has many bioactive ingredients, such as linalool, lavandulol, anthocyanins, geraniol, ursolic acids, linalyl acetate, valeric acid, 1,8-cineole, borneol, lavandulyl acetate, terpinen-4-ol, camphor, phytosterols, coumaric acid, and glycolic acid. The genus Lavender exhibits various biological activities, including antioxidants, antiparasitic, and neuroprotective properties. Recent studies have demonstrated the numerous biological activities of Lavandula, but we still need to develop new medications that harness the components of this plant to treat a variety of illnesses. This study covers various recent advancements in the use of Lavender and its phytochemicals by using various search engines, including Scopus, PubMed, Google Scholar, and Web of Science.

Background: Marine algae stand out as repositories of bioactive metabolites, widely harnessed in treating diverse diseases. Given the often-challenging side effects associated with conventional cancer treatments, researchers are increasingly turning their attention to marine algae as a promising source for discovering novel and potent anticancer compounds. In this study, we meticulously explored the potential anticancer activity of Spatoglossum variabile and Gracilaria corticata sourced from the Indian Ocean. Materials and Methods: The secondary metabolites were extracted using methanol solvent according to the standard protocol. The extract was subjected to GC-MS analysis and evaluated for its short- and long-term cytotoxicity and anti-proliferative ability in the HCT116 cell line using MTT, clonogenic, and trypan blue dye exclusion assays, respectively. Results and Discussion: The methanolic extract of Spatoglossum variabile contained 21 unique anticancer compounds, except for the other bioactive compounds. The results indicate that increasing the concentration of algal extracts decreased the cell viability significantly, with an IC50 of 51.49 μg/mL and 37.50 μg /mL in the HCT116 cell line. The results showed a significant reduction in colorectal cancer colony formation and a gradual reduction in cell proliferation. These results underscore the potential for targeted, low-toxicity biomedicines due to their selective cytotoxicity against cancer cells. Conclusion: Our findings show that Spatoglosuum variabile & Gracilaria corticata extracts contain various bioactive compounds, display long-term and short-term cytotoxicity and antiproliferative effects, which indicates that their constituent compounds might be further refined into effective anti-colorectal cancer medications.

Introduction: By condensing 2-aminothiazole and phenacyl bromide, a novel catalystfree synthetic approach for the synthesis of imidazo[2,1-b]thiazole derivatives has been developed. Methods: In this work, aloe vera/water (3:2) is used as a reusable, environmentally benign, greenpromoting media to synthesize desired products. This method enables the synthesis of a diverse range of aryl-substituted imidazo[2,1-b]thiazoles. Results: This solvent system demonstrates remarkable efficiency and offers numerous advantages, including shorter reaction times, the absence of side product formation, costeffectiveness, excellent atom efficiency, straightforward operation, and high yields. Conclusion: In conclusion, we successfully developed a green protocol for the environmentally benign synthesis of imidazo[2,1-b]thiazole derivatives using aloe vera water as green-promoting media.

Abstract: Breast cancer remains a major global health concern, ranking among the leading causes of illness and mortality in women worldwide. Despite the effectiveness of conventional treatments such as surgery, chemotherapy (CT), endocrine therapy (ET), radiation therapy (RT), and targeted therapies, these approaches often fall short in providing a cure for advanced-stage patients and frequently result in adverse side effects. This limitation drives the ongoing search for therapeutic natural compounds with minimal or no side effects. Alkaloids, in particular, have garnered attention for their broad spectrum of therapeutic properties against various malignancies, including breast cancer. The objective of this review is to systematically evaluate the therapeutic potential of 14 selected alkaloids that have been tested in in vitro and some in vivo models of breast cancer along by focusing on their mechanistic actions targeting key molecular signaling pathways involved in breast cancer progression. Majorly, the capability of alkaloids to induce cell cycle arrest, pro-apoptotic mechanisms via modulating various molecular signaling pathways were discussed. Notably, pathways such as the intrinsic and extrinsic mitochondrial apoptotic pathways, PI3K/AKT/mTOR, RAS/RAF/MEK/MAPK, Wnt/β-catenin, and NF-κB cascades were highlighted. Insights into conclusion the isoquinoline and indole derivatives, particularly berberine, piperine, capsaicin, matrine, and harmine, have demonstrated significant potential effects and these compounds also exhibited the ability to overcome drug resistance, and shown synergistic effects with conventional therapies. Finally, this comprehensive review could provide an overall insight into the application of these alkaloid compounds towards the prevention of breast cancer and a foundation for future studies aimed at improving their clinical effectiveness, offering valuable prospects.