All Research Papers Published In Current Opinion in Genetics & Development

Research Article
10.1016/j.gde.2026.102476

Wound-triggered plasticity in plant regeneration.

Apr 23, 2026
Current opinion in genetics & development
Max Minne + 1 more +1

Research Article
10.1016/j.gde.2025.102429

Polymer simulations of chromatin: connecting 3D organization and dynamics to function.

Feb 01, 2026
Current opinion in genetics & development
Shuvadip Dutta + 1 more +1

Research Article
10.1016/j.gde.2025.102427

Cooperativity between regulatory elements acts as a modulator of enhancer function.

Feb 01, 2026
Current opinion in genetics & development
Deevitha Balasubramanian + 2 more +2

Research Article
2
10.1016/j.gde.2025.102383

Dynamic three-dimensional epigenomic reorganization for the development of undifferentiated spermatogonia in mice.

Oct 01, 2025
Current opinion in genetics & development
Masahiro Nagano + 1 more +1

Research Article
3
10.1016/j.gde.2025.102353

Rewinding the clock: mechanisms of dedifferentiation.

Aug 01, 2025
Current opinion in genetics & development
Amelie A Raz + 1 more +1

Research Article
1
10.1016/j.gde.2025.102375

The Yin and Yang of replicative aging and rejuvenation.

Aug 01, 2025
Current opinion in genetics & development
Wei-Han Lin + 2 more +2

Budding yeast undergoes replicative aging through asymmetric cell divisions. Yeast mother cells progressively age as they generate successive daughter cells, until they ultimately die. However, their daughters are born rejuvenated, that is, most of them recover a full lifespan potential, with little impact of their mothers' age at their birth. In this review, we will discuss recent findings regarding the mechanisms of replicative aging and rejuvenation. Based on these insights, we will also discuss which evolutionary forces may havepresided over the emergence of aging in yeast. We suggest that aging and rejuvenation represent two adaptive strategies that each bring their own benefits.

Research Article
2
10.1016/j.gde.2025.102368

Recent advances in interspecies chimeras and organogenesis.

Aug 01, 2025
Current opinion in genetics & development
Jia Huang + 2 more +2

Research Article
11
10.1016/j.gde.2025.102369

Transcriptional adaptation: where mRNA decay meets genetic compensation.

Aug 01, 2025
Current opinion in genetics & development
Lara Falcucci + 2 more +2

Nonsense-mediated mRNA decay (NMD) is a translation-coupled quality control mechanism that safeguards cells against faulty transcripts that could lead to truncated and potentially harmful proteins. However, we posit that there is another side to NMD: it does not just clear away defective transcripts, it also triggers a form of genetic compensation known as transcriptional adaptation (TA). This recently discovered cellular response operates independently of protein loss. Instead, mutant mRNA decay can lead to the upregulation of functional paralogs, thereby compensating for the loss of the mutated gene. Consequently, TA could play a prominent role in genotype-phenotype correlations in human genetic diseases.

Research Article
2
10.1016/j.gde.2025.102354

Molecular basis of cell fate plasticity - insights from the privileged cells.

Aug 01, 2025
Current opinion in genetics & development
Stephen Maxwell Scalf + 2 more +2

Front Matter
10.1016/j.gde.2025.102355

Editorial overview: Emerging perspectives in genome architecture and gene regulation.

Aug 01, 2025
Current opinion in genetics & development
Marcelo Nollmann + 1 more +1