IntroductionResilience is the capacity to bounce back from adversity, and this concept has been extensively studied across various populations, especially those facing significant stress. In this context, Tunisian women have recently encountered multiple challenges related to balancing professional and family responsibilities, which require them to demonstrate strong resilience. Recent literature has highlighted a strong link between social support and resilience.ObjectivesThis study aims to explore the impact of social support on the psychological resilience of Tunisian women.MethodsThis cross-sectional study surveyed Tunisian women aged 18 and above using an online questionnaire between June and August 2024. Familial and professional characteristics were collected through a structured survey. Social support was measured using the Multidimensional Scale of Perceived Social Support (MSPSS), and psychological resilience was assessed with the 25-item Connor-Davidson Resilience Scale (CD-RISC 25).ResultsData from 695 Tunisian women (mean age = 36.72 ± 12.23 years) revealed diverse backgrounds: 24.7% were students, 35.3% worked in the public sector, 21.2% were self-employed, and 14.7% were unemployed. In terms of marital status, 42.9% were single, 49.2% married, and 5.6% divorced, with 8.5% living alone, 75.7% in nuclear families, 10.4% in extended families, and 5.5% in shared housing; additionally, 50.6% had children. The average resilience score was 68.26 ± 14.09, with 26.3% exhibiting low resilience. Social support scores were as follows: familial support (20.06 ± 6.38), friend support (18.17 ± 6.47), significant other support (21.2 ± 6.22), and overall social support (59.42 ± 15.26). Significant associations were found between resilience and marital status (p = 0.019), with married women showing lower rates of low resilience (21.3%) than single women (31.9%). Women with children also demonstrated higher resilience (p = 0.002), while employment status had a notable impact (p = 0.005), with low resilience rates highest among unemployed women (36.3%) and lowest among public sector workers (19.6%). Resilience positively correlated with social support across all sources: familial (p < 0.001, r = 0.269), friend (p < 0.001, r = 0.260), significant other (p < 0.001, r = 0.289), and overall social support (p < 0.001, r = 0.338).ConclusionsOur findings underscore the crucial role of social support and family connections in enhancing the psychological resilience of Tunisian women. Therefore, targeted social interventions are needed to support women experiencing loneliness or lacking social networks, aiming to strengthen their resilience and overall well-being.Disclosure of InterestNone Declared

IntroductionAdolescents face significant stress, which can undermine their subjective health, often manifesting as psychosomatic symptoms. Perceived self-efficacy is a critical resource for resilience, potentially buffering the impact of stress on subjective health. While action self-efficacy indicates one’s perceived ability to set goals and take initiative, coping self-efficacy refers to one’s ability to achieve the goals. By investigating both components, researchers and mental-health professionals can better understand how different aspects of self-efficacy influence the stress-symptom relationship, providing a more nuanced view of coping mechanisms.ObjectivesThe aim of this study is to determine how these key components of self-efficacy - action self-efficacy and coping self-efficacy - moderate the relationship between stress and psychosomatic symptoms.MethodsThe analyses were based on the Hungarian contribution to the representative international Health Behaviour in School-aged Children (HBSC) survey, collected in 2021/2022. The study population comprised self-report data from high-school students (N = 3,410; mean age = 16.77 years). We examined the main effects of self-efficacy dimensions and perceived stress, and their interactions in explaining psychosomatic complaints, using linear regression analysis with Hayes’ PROCESS macro (Model 1) in SPSS. Age and gender were controlled for as covariates.ResultsCoping self-efficacy: The overall model explained 33% of the variance in psychosomatic symptoms (R² = 0.33, F(5, 3404) = 330.96, p < .001). The results showed that stress (b = 1.93, p < .001), coping self-efficacy (b = 2.18, p = .02), and their interaction (b = -0.33, p = .002) were significant explanatory variables. This suggests that the relationship between stress and psychosomatic symptoms is weaker among adolescents who reported stronger coping self-efficacy. Action self-efficacy: In contrast, the interaction between stress and action self-efficacy was not significant (p = .16), implicating that the ability to set goals did not mitigate the effect of stress on symptoms.ConclusionsThe findings imply that coping self-efficacy significantly reduces the relationship between stress and psychosomatic symptoms. Adolescents with stronger coping skills are better equipped to mitigate the adverse effects of stress. However, action self-efficacy did not show a significant moderating effect, highlighting the distinct roles different self-efficacy components play in stress management. These results emphasize the importance of enhancing coping skills, such as cognitive reappraisal, in primary prevention interventions to reduce stress-induced psychosomatic symptoms.Keywordsadolescents, HBSC, psychosomatic symptoms, self-efficacy, stressThis study was supported by the Hungarian National Research, Development, and Innovation Office (K139265 and K143764).Disclosure of InterestNone Declared

IntroductionMajor depression not only impairs individual health and labour market performance but also imposes significant economic burdens on society. It is linked to substantial costs through healthcare use, lost productivity and absenteeism. Recent genome-wide association studies have identified genetic markers associated with major depression, offering new insights into its genetic risk factors. However, the potential association of these genetic risks with educational attainment and career outcomes remains underexplored. Understanding this connection is crucial for addressing the broader public health and socio-economic implications of depression risk beyond clinical populations.ObjectivesThis study aims to investigate the relationship between genetic risk for depression and individual career performance in the general population of Finland from 1992 to 2017.MethodsWe utilised pooled data from the Finnish Finrisk (1992-2012) and FinHealth (2017) studies, which together include a population representative sample of individuals aged 25-64 (N=20,121). Genetic, survey and socio-economic registry data were integrated for this analysis. Using probit and semi-structural regression models, we examined various career performance indicators, with polygenic scores for depression (Howard et al. Nat Neurosci 2019; 22 343-352) as the main explanatory variable. Socio-demographic characteristics and genetic principal components were included as controls.ResultsOur study revealed a negative association between higher genetic risk for depression and the likelihood of attaining higher education—an essential predictor of career success. Additionally, our study provides novel insights into how elevated polygenic risk for depression was linked to employment and self-employment rates, both directly and via educational pathways.ConclusionsThese findings highlight that genetic predispositions for depression can adversely affect career prospects in the general population, suggesting that the economic burden of depression extends beyond those clinically diagnosed. As effect sizes are modest, our results imply that supportive measures and compensatory behaviours could mitigate some of the educational and career disadvantages associated with higher genetic risk for depression.Disclosure of InterestA. Hazak: None Declared, J. Liuhanen: None Declared, K. Kantojärvi: None Declared, S. Sulkava: None Declared, T. Jääskeläinen: None Declared, V. Salomaa: None Declared, S. Koskinen: None Declared, M. Perola: None Declared, T. Paunio Consultant of: Idorsia Pharmaceuticals and Biogen (unrelated to the present work)

IntroductionAdolescence is a critical period of physical, cognitive and emotional development. Mental health among adolescents is a major public health issue. The number of teenagers requiring psychiatric care is constantly increasing and several studies have found high prevalences of psychiatric disorders in this group.ObjectivesThe aim of the study was to describe sociodemographic and clinical characteristics of adolescents hospitalized in an adult psychiatric department.MethodsWe carried out a retrospective descriptive study. It included adolescent patients, aged between 16 and 19 years, who were admitted to the department G of Razi Hospital (Tunisia), between May 2019 and May 2024 (the minimum age for hospitalization in adult psychiatric wards was 16). Data were collected from patients’ files.ResultsThirty-five adolescents were included. The mean age was 17.8 ± 0.8 years. A male predominance was noted with 65.7% of patients. We found that 57.1% of teenagers were using at least one psychoactive substance. Tobacco was the most used substance (54.3%), followed by cannabis (42.9%) and alcohol (40%). The most common motive for hospitalization was behavioral disturbances with 79.1% of patients. The most common psychiatric disorders were schizophrenia (32.6%) and schizophreniform disorder (18.6%). Antipsychotics were the most prescribed medication (58.13%) followed by benzodiazepines (30%).ConclusionsKnowing the profile of adolescents hospitalized in psychiatry, their sociodemographic and clinical characteristics would enable us to better the care we offer to them.Disclosure of InterestNone Declared

IntroductionThe Lancet Commission on dementia prevention, intervention and care and the WHO Guidelines on risk reduction of cognitive decline and dementia provide evidence-based recommendations on lifestyle behaviours and interventions to delay or prevent cognitive decline and dementia. Due to demographic change and because new developments in pharmacotherapy are not suitable for all patients, there is a great need for non-pharmacological interventions. The MEMODIO app was developed to provide a multi-domain therapy for users with Mild Cognitive Impairment (MCI) and dementia. A screenshot of the app is shown in Image 1.ObjectivesThe aim of this study was the exploratory evaluation of whether an app-based therapy can improve cognitive function in patients with MCI and mild dementia. For the interim analysis as of October 2024, the results of the MCI study arm are reported (n=42).MethodsOne hundred forty patients with confirmed diagnosis of MCI [Montreal Cognitive Assessment (MoCA) score 21-25] or Mild Dementia (MoCA score 14-20) were randomized to an intervention (IG) or standard of care (SoC) group. IG patients received SoC plus the MEMODIO app, providing cognitive and physical exercises, as well as psychoeducation on a brain-healthy diet and risk factors for cognitive decline, for 12 weeks. MoCA, Amsterdam Instrumental Activity of Daily Living Questionnaire - Short version (A-IADL-Q-SV) Dementia-Related Quality of Life (DEMQOL) as well as Physical Activity Questionnaire (PAQ 50+) were collected at baseline and study end.ResultsIn the MCI group, the mean age was 71 years, 20 out of 42 patients were female. Preliminary outcomes are shown in Images 2 and 3.The preliminary analysis on MCI patients (mean age: 71 y ±9,49 SD, 48% were female) showed statistically significant improvements in MoCA in the IG (-0.84±3.5 SoC vs. 1.96±2.7 IG, p=0.006). Quality of life, physical activity and activities of daily living at the time point of the interim evaluation were not significantly different from baseline, but the activity level measured by PAQ showed a non-significant improvement in the SoC group.Image:Image 2:Image 3:ConclusionsIn this RCT, a significant improvement in cognition was shown in MCI-patients using the MEMODIO app compared to those receiving SoC alone. Further analyses are ongoing.Disclosure of InterestG. Nelles Grant / Research support from: PI of MEMODIO@APP_CARE, T. Steinmann Employee of: memodio GmbH, D. Stein Shareolder of: memodio GmbH, V. Weil Employee of: memodio GmbH, A. Bicu: None Declared, C. Polidori: None Declared