Emerging evidence suggests that creatine, a naturally occurring amino acid derivative and conditionally essential nutrient, may modulate cellular senescence through mechanisms such as enhancing cellular energy homeostasis, mitigating oxidative stress, and influencing key signaling pathways implicated in aging processes. This review critically evaluates the current body of research, highlights existing gaps in the mechanistic understanding, and emphasizes the importance of targeted studies to further delineate creatine's role in cellular senescence and age-associated dysfunctions. By integrating perspectives from molecular biology, gerontology, and applied physiology, this paper aims to advance the understanding of creatine-based strategies as potential interventions for promoting healthy aging and preventing senescence-associated conditions.

The purpose of this study was to evaluate the benefits of the Baduanjin exercise and nutrition intervention on Cancer-related fatigue (CRF) in elderly lung cancer patients undergoing chemotherapy. 96 elderly patients suffering from lung cancer and undergoing chemotherapy were enlisted and randomly assigned to the control group, the exercise group, and the exercise plus nutrition group. Primary and secondary endpoints were assessed at baseline, week 6, and week 12, including Brief Fatigue Inventory (BFI) scores, Pittsburgh Sleep Quality Index (PSQI) scores, grip strength, and gait speed. Significant beneficial intervention effects were found for CRF, sleep quality, grip strength, and gait speed in the exercise plus nutrition group at 6 and 12weeks after the treatment. The exercise group improved CRF, grip strength, and gait speed at 12weeks. No beneficial effects on the outcomes were noticed in the control group. Baduanjin exercise may help alleviate CRF in elderly lung cancer patients undergoing chemotherapy. Moreover, when combined with nutrition intervention, it appears to enhance their sleep quality and physical function more substantially than Baduanjin alone.

Long-term exercise is recognized as one of the most effective means of maintaining health after aging, but the relationship between moderate exercise and health in the older population is often overlooked. The present study was conducted to investigate the effects of excessive endurance exercise on the old mice musculoskeletal system. The 8weeks of normal endurance exercise significantly improved skeletal muscle mitochondrial biogenesis and increased femoral osteogenesis in young and old mice. However, the continued accumulation of total exercise volume as the exercise cycle was prolonged resulted in the younger and older mice exhibiting different exercise effects. After 8-16weeks of moderate-intensity endurance exercise, young mice showed consistent effects of increased mitochondrial biogenesis in skeletal muscle. However, after 12-16weeks of moderate-intensity endurance exercise, the original effects of exercise-induced mitochondrial biosynthesis were instead impaired in older mice. After 16weeks of exercise, the aged mice showed a produces consumptive weight loss, an increase inflammation level in adipose tissue, and a decrease in femoral bone mineral density. Interestingly, with an increase in total exercise, the level of skeletal muscle inflammation in old mice did not increase significantly, while a longer exercise cycle reduced the level of skeletal muscle apoptosis, thereby maintaining the state of skeletal muscle. Appropriate moderate-intensity endurance exercise has a significant gain in maintaining musculoskeletal health in aged mice. However, excessive endurance impairs the health of the musculoskeletal system in aged mice.