ABSTRACTCyclic dinucleotides, which act as agonists for the stimulator of interferon genes (STING), are pivotal in stimulating both adaptive and innate immune reactions for advancing cancer immunotherapy. However, their therapeutic potential is hampered by inherent limitations, including susceptible degradation and inefficient delivery. Herein, we design genetically engineered bacteria (2'3'‐cGAMP@E.coli) capable of producing 2'3'‐cGAMP in the cytoplasm and then fabricate personalized nanovaccines (nECTs) by assembling 2'3'‐cGAMP@E.coli with autologous tumor antigens instead of complicated chemical synthesis. Our in vitro analysis confirms that nECTs are capable of potently stimulating dendritic cell activity and amplifying the cross‐presentation of antigens by leveraging the STING signaling route, underscoring their potential to bolster immune response priming. Translating these findings into in vivo models, vaccination with nECTs leads to a pronounced infiltration of effector T cells into tumor sites, concurrent with an IFN‐β‐mediated remodeling of the suppressive tumor microenvironment by innate immune cells. Notably, the therapeutic efficacy of nECTs is further augmented when coupled with a fasting‐mimicking diet regimen, highlighting the synergistic potential of this combinatory strategy. Collectively, this dual modality represents a significant stride towards enhancing the precision and effectiveness of immunotherapeutic interventions in oncology.

ABSTRACTThe design of green and low‐cost Z‐scheme heterojunctions with the interfacial electric field (IEF) is of prime importance to their photocatalytic hydrogenation performance and practical application. In this work, we construct a novel Z‐scheme heterojunction photocatalyst comprised of Zn‐Ni2P/g‐C3N4 nanosheets for hydrogen evolution reaction (HER). Experimental results and density functional theory calculations demonstrate that the construction of Z‐scheme Zn‐Ni2P/g‐C3N4 heterostructure not only promotes the generation of IEF directing from Zn‐Ni2P to g‐C3N4, along with work function, accelerating the photogenerated charge separation in Zn‐Ni2P/g‐C3N4, but also leads to the upshift of the p‐band state density in Zn‐Ni2P/g‐C3N4, favorable for the H* adsorption toward HER. The Zn‐Ni2P/g‐C3N4 photocatalyst demonstrated excellent photocatalytic HER activity, with a hydrogen production rate of up to 1077 µmol g−1 h−1 and a stability of 49 h. Our findings provide a new method to enhance the separation of photogenerated charges. This improvement boosts the photocatalytic properties of solar‐driven materials and devices.

[This corrects the article DOI: 10.1002/EXP.20230113.].

ABSTRACTFlexible ionic conductive electrodes, as a fundamental component for electrical signal transmission, play a crucial role in skin‐surface electronic devices. Developing a skin‐seamlessly electrode that can effectively capture long‐term, artifact‐free, and high‐quality electrophysiological signals remains a challenge. Herein, we report an ultra‐thin and dry electrode consisting of deep eutectic solvent (DES) and zwitterions (CEAB), which exhibit significantly lower reactance and noise in both static and dynamic monitoring compared to standard Ag/AgCl gel electrodes. Our electrodes have skin‐like mechanical properties (strain‐rigidity relationship and flexibility), outstanding adhesion, and high electrical conductivity. Consequently, they excel in consistently capturing high‐quality epidermal biopotential signals, such as the electrocardiogram (ECG), electromyogram (EMG), and electroencephalogram (EEG) signals. Furthermore, we demonstrate the promising potential of the electrodes in clinical applications by effectively distinguishing aberrant EEG signals associated with depressive patients. Meanwhile, through the integration of CEAB electrodes with digital processing and advanced algorithms, valid gesture control of artificial limbs based on EMG signals is achieved, highlighting its capacity to significantly enhance human‐machine interaction.

ABSTRACTAsymmetrical pleated textile with unidirectional water transport plays a vital role in maintaining personal moisture and thermal comfort. Inspired by the cactus branch, in this work, an asymmetrical pleated structure textile embedded with a unidirectional water transport channel was proposed by seamless weft knitting technology. This innovative textile with differential capillary effect can swiftly transport water within 1 s, with an accumulative one‐way transport index (AOTI) of 499.57%. This textile also exhibits excellent external water repellency with a stable contact angle exceeding 120°. Most importantly, water repellency, water collection, and directional water transport ability are integrated into one unified system by means of the asymmetrical pleated structure, thereby ensuring both safety and comfort for the wearer. The advanced fabrics meet high transmission indexes and fast transport rates, which are expected to provide a fresh avenue for the development and creation of more efficient and adaptive personal moisture and thermal management fabrics.

ABSTRACTThe pursuit of developing groundbreaking pro‐regenerative therapies to expedite skin wound healing persists as a formidable challenge. Peptide RL‐QN15, emerges as a highly promising candidate for the first pro‐regenerative drug derived from amphibian skin, offering a glimmer of hope for innovative healing treatments. Yet, there is an urgent need for intensified research efforts to propel RL‐QN15 from a molecular entity to a viable drug candidate, particularly in unraveling the mechanisms underlying its exceptional pro‐healing efficacy. In the current research, our results revealed that RL‐QN15 significantly enhanced the proliferation, migration, stemness, and epithelial‐to‐mesenchymal transition of human epidermal stem cells (hESCs) through direct binding to the membrane frizzled 8 (FZD8) receptor. This interaction triggers the downstream Wnt/β‐catenin signaling pathway, leading to the up‐regulation of target genes MYC and CCND1. Furthermore, RL‐QN15 augmented the expression and secretion of matrix metalloproteinase‐3, which degrades E‐cadherin and activates the Wnt/β‐catenin pathway, thereby amplifying RL‐QN15's regulatory effects on hESCs. In summary, our findings have demonstrated that RL‐QN15 modulated the functions of ESCs to accelerate skin wound regeneration via the FZD8/β‐catenin axis. This research not only advances peptide RL‐QN15 from a molecular entity to a drug candidate by shedding light on the mechanisms involved with regulation of ESCs functions, but also presents compelling evidence implicating FZD8 as a novel therapeutic target for skin wound regeneration.

ABSTRACTThe concept of the microbiota‐gut‐brain axis has witnessed significant advancements, and observational studies revealed dysbiosis in the gut microbiota of patients with brain tumors. The causal relationship between gut microbiota and brain tumors and the potential prognostic value of microbiota are still unclear. Based on multiple Mendelian randomization analyses, this study confirms the causal effects of four gut microbes on meningioma, seven gut microbes on pituitary tumor, and eight gut microbes on glioma. Based on the Sherlock framework, this study identifies 103 meningioma‐related microbe‐related genes (MRGs), 40 pituitary tumor‐related MRGs, and 63 glioma‐related MRGs expressed in brain tissues. Almost all glioma‐related MRGs are associated with tumor grade and prognosis. Lastly, the prognostic model based on machine learning and microbiota established in this study, namely microbe‐related signature (MRS), could robustly predict the prognosis of glioma and provide insights for immunotherapy benefits. This study presents evidence of the causal effects of gut microbes on brain tumors, which contributes to our understanding of the microbiota‐gut‐brain axis. The relationship between glioma‐related MRGs and glioma prognosis, along with the prognostic prediction capacity of MRS and its association with immunotherapy, provides support for the use of gut microbiota as biomarkers to evaluate the prognosis and treatment response of glioma.

ABSTRACTAtomic layer deposition (ALD) technique has emerged as a fascinating tool for the design and synthesis of heterogeneous catalysts with atomic precision for energy conversion, generation, and storage applications. Here, we demonstrate the importance of the ALD for catalyst design by citing recently reported works, in particular, the emphasis has been given to the surface/interface engineering of catalysts for improving their catalytic efficiency in energy applications. To get insight into the reaction mechanism, the ALD‐based routes for catalyst synthesis may revolutionize the field of sustainable energy conversion and storage. Moreover, the synthesis of supported nanoparticles with controlled shape and size has attracted great attention in catalysis owing to their unique properties. By taking advantage of the ALD, it is possible to synthesize catalysts at the atomic scale, particularly, site‐selective ALD provides tremendous opportunities in catalytic efficiency and selectivity studies. Moreover, this review illustrates diverse heterogeneous catalysts with their limitations for energy‐related applications and how the ALD technique can facilitate overcoming them. Finally, we deliberate the advancement in the ALD technique on heterogeneous catalyst design, and interface engineering of catalysts, and outline future perspectives of this technology in catalysis.

ABSTRACTCoatings have attracted widespread attention in the field of corrosion protection of metals because of their corrosion resistance and convenient techniques. Unfortunately, till now, traditional coatings have the shortcomings of vulnerability and passive corrosion protection, hence functional coatings progressively replace them. Endowing coatings with additional functions not only transform them into active protection mechanisms but also significantly improve life cycle of coatings. However, there is only limited success in combining multiple functions of coatings, which poses considerable obstacles to further advancement of their application researches. In this paper, we summarize the research progress of self‐warning and self‐repairing coatings in the field of metal corrosion protection as much as possible from the perspective of functional material selection. Meanwhile, the current progress of substituting dual‐functional coatings for single‐functional coatings is also highlighted. We aim to provide more options and strategic guidance for the design and fabrication of functional coatings on metal surfaces and to explore the possibilities of these designs in practical applications. Last but not least, the remaining challenges and future growth regarding this field are also outlined at the end. It is hope that such an elaborately organized review will benefit the readers interested to foster more possibilities in the future.