Physics-Informed and Data-Driven Machine Learning for Magnetic Hyperthermia of Fe <sub>3</sub> O <sub>4</sub> Nanoparticles
This work presents, for the first time, a Physics Informed Neural Network (PINN) model for magnetic hyperthermia, a promising non-invasive cancer therapy known for its high efficacy and minimal side effects. Effective cancer cell destruction requires heating to 42-45 °C. The heat generated by magnetic nanoparticles (MNP) under an alternating magnetic field depends strongly on their physicochemical properties. Hence, the optimization of MNP for effective heat generation remains a key challenge and constitutes the fundamental motivation of this study. In this work, we study and compare various approaches employing regression models, Artificial Neural Network (ANN), and PINN to address the challenges associated with magnetic fluid hyperthermia (MFH) prediction and analysis. The model incorporates input parameters, including particle size, saturation magnetization, magnetic field intensity, frequency, specific heat of fluid, nanoparticle concentration, and time, to predict temperature evolution as the output. The dataset is compiled from our published research work, comprising 3,690 data points, ensuring sufficient variability and robustness for model training and evaluation. Our PINN model shows an excellent R<sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> value of around 0.98 against the test data.
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