A simple and sensitive static head space gas chromatographic (SH-GC) method equipped with FID has been developed and validated for simultaneous determination of residual solvents e.g., methanol, dichloromethane and toluene in two therapeutic drugs such as amoxicillin and ampicillin. The separation was achieved with 30 m long Elite - 5 fused silica capillary column and 0.32 mm inner diameter. The developed SH-GC method offered symmetric peak shape, good resolution and reasonable retention time for all the solvents. Beer’s law was obeyed in the concentration ranges 100 – 1200, 50 – 1000 and 50 – 500 ppm for methanol, dichloromethane and toluene, respectively. The method was validated according to international conference on harmonization (ICH) guidelines in terms of specificity, linearity, precision, accuracy, limit of detection, limit of quantitation, robustness and solution stability. The degrees of linearity of the calibration curves, the percent recoveries, relative standard deviation for the method were also determined. All the validation parameters were within the acceptable range. The developed SH-GC method could, therefore, be suitable for simple and rapid detection of trace levels residual solvents in other pharmaceutical products and thereby it could be used for routine analysis in any analytical laboratory.

ABSTRACT Objectives: to find the efficacy dutasteride and green tea in reducing hemorrhage on TURP patients and to evaluate the anti- angiogenesis effect. Methods: Double Blind Randomized Controlled Trial Post Test Only, with 80 samples, randomized into 4 groups: 1 control group and 3 treatment groups (P1 with 0.5 mg of dutasteride, P2 with a capsul of green tea, and P3 with combination of 0.5 mg dutasteride and a capsul green tea at least 14 days before TURP. We compared the ΔHb define the VEGF expression and MVD count to evaluate the angiogenesis changes between 4 groups. The difference is considered statistically significant with p < .05. Results: ΔHb (-0.40 + 0.246) pg/ml for control group, (-0.20 + 0.067) pg/ml for P1 group, (-0.18 + 0.081) pg/ml for P2 group, and (-0.14 + 0.092) pg/ml for P3 group. VEGF expression were (20.20 + 17.386), (12.90 + 15.509), (11.60 + 9.121), and (3.60 + 1.667) for control, P1, P2, and P3 group respectively. MVD count were (41.20 + 10.273), (32.75 + 9.318), (26.15 + 7.278), and (18.35 + 7.876) for control, P1, P2, and P3 group respectively. The result from between-subject effect tests showed statistically significant differences in ΔHb (p<0.001), VEGF expression (p<0.001), and MVD count (p<0.001). Dutasteride and green tea significantly reduce the hemorrhage during TURP by decreasing the MVD. Conclusion : Administration of 0.5 mg dutasteride and 725 mg of green tea, 14 days prior to TURP significantly reduce the hemorrhage during TURP (Δ Hb) by decreasing the MVD

Quantum Dot Cellular Automata (QCA) is a promising nanotechnology in Quantum electronics for its ultra low power consumption, faster speed and small size features. It has significant advantages over the Complementary Metal–Oxide–Semiconductor (CMOS) technology. This paper present, a novel QCA representation of Six-Correction Logic (SCL) gate based on QCA logic gates: the Maj3, Maj AND gate and Maj OR. In order to design and verify the functionality of the proposed layout, QCADesigner a familiar QCA simulator has been employed. The simulation results confirm correctness of the claims and its usefulness in designing a digital circuits.

Present study deals with the buoyancy-driven MHD mixed convection stagnation-point flow, heat and mass transfer of a nanofluid over a non-isothermal stretching sheet in presence of induced magneticfield, radiation, chemical reaction, suction/injection and heat source/sink. The basic governing partial differential equations are reduced to a set of ordinary differential equations by using appropriate similarity transformation. The resulting system is solved numerically by bvp5c Matlab package. Numerical results are validated by comparing with the published results. The influence of non-dimensional governing parameters on velocity, induced magneticfield, temperature and concentration profiles along with coefficient of skin friction, local Nusselt and Sherwood numbers are discussed and presented with the help of graphs and tables. Comparisons are made with the existed studies. Results indicate that dual solutions exists only for certain range of suction/ injection parameter and injection parameter have tendency to enhance the momentum, thermal and concentration boundary layer thickness.

The corrosion behaviour of the intermetallic compounds Ni3(Si,Ti) (L12: single phase), has been investigated using an immersion test, polarization method, scanning electron microscope in 0.5 kmol/m3 H2SO4 solution at 303 K. Moreover, the corrosion behaviour of austenitic stainless steel type 304 was studied under the same experimental conditions as reference. It was found that the intergranular attack and uniform attack were observed on Ni3(Si,Ti) after thermomechanical and annealing processes (1173K and 1273K) respectively in the immersion test. From the immersion test and polarization curves, all annealed Ni3(Si,Ti) had less corrosion resistance compared to type 304. In addition, Ni3(Si,Ti) was difficult to form a stable passive film, but not for type 304.

Gracilaria verrucosa (Hudson) Papenfuss has great potential to be farmed in the water resources in Indonesia. As natural resource, the weed has a major contribution in the field of industry both for human food and health. Efforts have been done intensively to increase the production capacity to meet the market demand especially gelatin, both national and international market. One of them is the application of plasma corona irradiation treatments on the weed to improve developmental pathways. The concept of plasma irradiation performed at atmospheric conditions may impact on nitrogen intrusion pathway that is important element in the growth of the weed. The aims of this study are to assess the potential impact of plasma irradiation in improving the growth of G. verrucosa and thus increase their biomass production. The treatments were done using five different duration of plasma irradiation, which were 2, 4, 6, 8, and 10 minutes at a 0,5mA stable source of voltage and 8kV of electrical current. Observations of growth rate include thallus length and biomass of G. verrucosa , that was observed every week for 28 days. The result showed that the growth of weed exhibited better than those without radiation. The best growth was reached in the group of treatment of 8 minutes irradiation, exhibited 65,91g of biomass and 9.5515% growth rate and length of thallus reached 22,33 cm and daily growth rate of 2.9759%. The lowest growth of the weed occurred in the treatment of 10 minutes irradiation, which was 44,82 g biomass, 8.123% growth rate, 17,13 cm thallus length with a daily growth rate of 1.9942%

The goal of this paper discusses about different types of data mining classification algorithms accuracies that are widely used to extract significant knowledge from huge amounts of data. Here illustrate 20 classifications of supervised data mining algorithms base on type-2 diabetes disease dataset perspective to Bangladeshi populations. In this paper we compare 20 classification algorithms by measuring accuracies, speed and robustness of those algorithms using WEKA toolkit version 3.6.5. Accuracies of classification algorithms are measured in 3 cases like Total Training data set, 10 fold Cross Validation and Percentage Split (66% taken). Speed (CPU Execution Time) and error rate also measured as like as accuracy. Firstly checked top perform algorithms that have best outcome for different cases and then ranked top outcomes algorithms. Finally ranked best 5 algorithms among 20 algorithms based on their accuracies.

This study is concerned with the synchronization problem for a class of chaotic systems with multiple time-delays and transmitted noise. A dynamic compensator is proposed to achieve the synchronization between master and slave chaotic systems with multiple timedelays. First, the neural-network (NN) model is employed to approximate the chaotic systems with multiple time delays. Then, a linear differential inclusion (LDI) state-space representation is established for the dynamics of the NN model. Based on the LDI state-space representation, an exponential stability criterion of error dynamics derived in terms of Lyapunov's direct method is proposed to ensure that the trajectories of the slave system can approach those of master system. Subsequently, the stability condition of this criterion is reformulated into a linear matrix inequality (LMI). Based on the LMI, a fuzzy controller is synthesized to realize the exponential synchronization of the chaotic master-slave systems. Finally, this study provides a numerical example with simulations is given to illustrate the concepts discussed throughout this work.

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Indonesia has more than 17,506 islands and 92 islands of them are outermost small islands. Lingayan is one of them located in Northwest of Sulawesi Island and it has geostrategic role to determine the sea boundaries of Indonesian State (NKRI) including the territorial seas, the exclusive economic zone and the continental shelf. Recently, the coastal ecosystems of Lingayan has degraded and the island’s economy is weak so they cannot support the life’s survival of inhabiting people. This condition could weaken the geostrategic role in accordance with article 121 Chapter VIII of the United Nations Convention on the Law of the Sea (UNCLOS). Based on the above reasons, the study aim to examine and assess the causal relation of components in the socio-ecological and socio-economical systems as a basis for management of the Lingayan Island with target on conservation of coastal ecosystems and growth of inhabitant’ business economic. Causalities relations within components were built using Statistic Equation Model (SEM) with AMOS method and 40 constructed indicators as well as determinate the suitability program using Analytical Hierarchy Process (AHP). The research showed that there is relationship between the components of socio-ecological systems as indicated by the fit model of causal relation path diagram that provides chi square value = 236.994, RMSEA = 0.083, GFI = 0.884. Furthermore, there is relationship between the components of socio-economical that provides chi square value = 192.824, RMSEA = 0.081, GFI = 0.900. The most appropriate programs are seaweed cultivation (34.0%) and restoration (23.4%).