- Research Article
- 10.1002/itl2.70184
<scp>6G</scp> ‐Enabled Federated Edge Intelligence: Multi‐Center Stroke Lesion Segmentation
- Nov 18, 2025
- Internet Technology Letters
- Siyu Zhao
ABSTRACT This paper proposes a 6G‐driven federated edge intelligence framework for multi‐center stroke lesion segmentation. Lightweight MobileStroke‐U‐Net is deployed at the edge of each participating hospital for distributed MRI segmentation, enabling federated learning without data sharing. Gradient adaptive weighted aggregation (GradAdapt) is used at the Center Server layer to alleviate heterogeneous distribution offset across multiple centers. The global model is trained in the cloud and combined with homomorphic encryption and blockchain auditing to achieve end‐to‐end privacy protection. Experiments are conducted on two major multi‐center datasets, ATLASv2.0 and ISLES22: Compared with the best single model, FL‐MobileStroke‐U‐Net improves Dice by 1%–2% on both datasets. FL‐MobileStroke‐U‐Net improves Dice from 0.6458 to 0.6611 on ATLAS v2.0, and the 95% Hausdorff distance changes from 22.9573 to 21.2032; on ISLES22, Dice increases from 0.7527 to 0.7632, and the 95% Hausdorff distance changes from 11.8847 to 11.0762. The results show that the proposed multi‐center federated framework effectively balances privacy, security, and efficiency, significantly improves cross‐center segmentation performance, and provides a new approach for 6G‐enabled intelligent stroke management.
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