In the recent past, several outbreaks of mosquito-borne diseases in Dehradun city make it necessary for a comprehensive understanding of man-vector contacts, disease transmission and determination of appropriate resting sites for adult mosquitoes. The study was conducted within the periphery of Dehradun city in Doon valley, Uttarakhand state, India consisting of eight (08) locations namely Sahaspur, Premnagar, Raipur, Karanpur, Sahastradhara, Dudhli, Doiwala and Rani Pokhri with the objective to analyze and assess the seasonal prevalence and host choice of the mosquitoes with special reference to Aedes species. Among the eight locations of the current study, Raipur registered the highest mosquito abundance (17%) trailed by Sahaspur (16%) and Karanpur (15%). A low abundance of mosquitoes was registered conjointly from Doiwala and Rani Pokhri areas (9% from each area). In these areas, the profile plots of the 2-way ANOVA displayed the highest variation for the data collected from human habitations followed by bovine sheds, whereas the lowest recorded variation was from the poultry. With regards to seasonal prevalence, the highest mosquito abundance was registered during the monsoon followed by the post-monsoon. In provender analysis, a total of 1912 blood meals were collected for antibody test among which 1851 were found positive, with the highest reaction with human antisera (57.75%), followed by bovine antisera (21.34%) and pigs antisera (4.97%). Ae. aegyptihad the highest Anthropophilic Index (A.I.) with 68.78%, followed by Ae. albopictus (64.89%) and Ae. vittatus (55.55%). However, Human Blood Predominance (H.B.P.) and Pure Human Blood Pervasiveness (P.H.B.P.) were found highest for Ae. albopictus with values 0.43 and 0.44 respectively. The results also show the seasonal prevalence and feeding habits of these vectors. This study would be helpful in formulating season-wise strategies for the control of Aedes vector mosquitoes in different eco-epidemiological situations.

Background: An ear infection, can be classified into otitis externs and otitis media, this affects all age groups especially infants and young. This infection associate with pathogenic microorganism type, frequent antibiotic uses, health care and age. The most common pathogenic bacteria of the ear infection are Pseudomonas spp. Antibiotic resistance represents a serious threat to the health of humans. Methods: 48 ear swabs were collected through the use of wooden sticks in a sterile container for the identification of Pseudomonas, Serratiaand Klebsiella species by VITEK 2 system and biochemical tests. The antibiotic susceptibility against these bacterial species was detected through the method of standard disk diffusion on the Moller Hinton agar. Results: Among ear swabs, the positive growth percentage of the pathogenic gram-negative bacteria was 29.166%, and the percentage of Pseudomonas spp. was 57.142%. Males were found to be more susceptible than females with an infection percentage of 57.142%. Conclusion: The antibiotic susceptibility patterns show the azithromycin, gentamycin, piperacillin, ceftriaxone, cefepime, imipenem, ceftriazon, and gentamycin have activity against Pseudomonas spp.

Purpose: To learn about the clinical profile, outcome and quality of life and factors influencing these, in critically ill patients with H1N1 pneumonia. Methods: Retrospective analysis of case files and phone interview of 88patients with confirmed H1N1 pneumonia. Results: Out of 88 patients, 51 were males. Mean age was 48.23 [± 13.03]. 39 [44.31%] were in the 31-50 years age group and 37 [42.04%] were in the 51-70 age group. Diabetes [n=16] and Hypertension [n=20] were the most common comorbidities. Majority of the patients presented with cough [n=87], breathlessness [n=85] and fever [n=84]. 43 patients had severe ARDS on admission. Mean APACHE II score was 9.6 [± 5.4] Mean SOFA scores 4.99 [± 2.6]. Mean Murray score was 2.37 [± 0.76]. 46 patients [52%] survived. Factors associated with mortality were APACHE score [p=0.00], SOFA score [p=0.00] Murray score, severe ARDS [p=0.00], requirement of vasopressor support [p=0.00] or renal replacement therapy [p=0.00] and incidence of VAP [p=0.039]. Diabetes had a protective effect [p=0.04], as had non-invasive ventilation [p=0.00]. Murray score [p=0.000, SOFA score [p=0.036], initiation of mechanical ventilation [p=0.003] and incidence of VAP [p=0.00] was associated with increased length of stay among the survivors. Conclusion: Higher lung specific severity scores, severe ARDS, secondary organ failure and VAP were associated with increased mortality. Among survivors, higher Murray and SOFA scores, mechanical ventilation and vasopressor use entailed a longer ICU stay.

Pyrethroids are powerful insecticides used in the vector control program with impregnated mesh, and residual indoor sprays. However, resistance to insecticide reduces the effectiveness. The present susceptibility study carried out against theAnopheles Stephensi to monitor the sensitivity conditions of An. Stephensi vector, which raises the need to understand the state of vector resistance in the Dungarpur region of Rajasthan, India in order to better report vector-based interventions. The sensitivity study was carried out by the WHO standard method using recommended diagnostic doses of DDT, alpha-cypermethrin, permethrin, and deltamethrin. An. Stephensi showed resistance to DDT from the entire study while sensitive to alpha-cypermethrin, permethrin, and deltamethrin. The study looks at the selection and circulation of the appropriate insecticide’s molecule for a vector control program as insecticide need constant monitoring to develop effective vector control strategies such as improving insecticide by applying integrated biological and ecological methods.

Introduction: Global rise in the Aedes-borne diseases and harmful effects of synthetic insecticides has diverted research to explore secondary metabolites in plants as mosquito control agent in the form of nanoparticles. Current study investigated Clitoria ternatea-mediated nanoparticles against Aedes aegypti. Methods: The aqueous and hexane leaf extracts of C. ternatea were assayed against Ae. aegypti early fourth instars. The extract-mediated silver nanocomposites (AgNCs) were synthesized after optimizing the volume and concentration of silver nitrate solution. The synthesis was tracked by the colour change of reaction mixture from pale yellow to dark brown followed by monitoring with UV-Visible spectroscopy and Dynamic Light Scattering. Results: The biosynthesis of 3 mM, 4 mM and 5 mM AgNCs was traced at 438, 401 and 407 nm, respectively. The average particle size distribution ranged from 34.62 to 60.64 nm and polydispersity index was 0.6-0.7. The 24 h larval exposure with aqueous and hexane leaf extracts demonstrated respective LC50 values of 53.057 and 42.179 mg/L, which decreased significantly on larvicidal assay with NCs. The 5mM AgNCs showed the maximum efficiency with LC50 of 10.317 mg/L after 24 h. Scanning and transmission electron microscopy images demonstrated a spherical, poly-dispersed structure with diameter in the 1-27 nm range. The assays against non-targets; Moina and Cyclops ascertained the eco-safety of NCs. Conclusion: The study demonstrated the C. ternatea leaf extract as possible effective mosquito nano-larvicide, alternate to traditional insecticides. Field studies, which could not be held due to the current pandemic, would further ascertain the possible use of these NCs against Aedes larvae.

In the present study, ascorbic acid’s or Vitamin C’s influence (VC) in inhibition of SARS-CoV-2 virus reproduction was investigated. Gaussian 09 with a basis set of 6-311G (d, p), MGL tools, DSV, and LigPlus software were used. According to the Total Electron Density (TED) and Millikan charges, the active sites for adsorption were determined. Further, the docking study had clearly revealed the role of VC in inhibition of the virus reproduction in accordance with binding energy (Eb) and ligand efficiency (LE). The vitamin’s interaction with the virus’s spikes may limit its replication or provide the immune system sufficient time to recognize the infection, which enhances the possibility of producing appropriate antibodies.

This study aims to examine the determinants of health-care expenditure in the Eastern region of Uttar Pradesh. Secondary data from the National Sample Survey Office (NSSO) of 75th round on social consumption related to health were utilized. The Heckman two-step selection model was used to analyse household and individual decisions to seek care. Findings of this study reveal that having household head aged between 31 to 60 and above 60 years, household size greater than 5 members, belonging to religion other than Hindu, non-ST category as Schedule caste, Other backward class and others, people residing in urban area, people having higher economic status, private hospitals, upper primary and secondary+ schooling of household head and having household members with chronic illnesses were determinants contributing more health-care spending. However, female household head had less likely to incur healthcare expenditure as compared to male household in the region. An important finding indicates that the majority of people visited private hospitals in the region which increased the health-care spending at large and it burdened financially to the vulnerable section of the society. Based on the discussion, a few policy suggestions have been proposed to counter the above problems.

Rabies is a fatal zoonotic disease which has tormented humanity since antiquity. It is transmitted after the bite of a rabid animal and is 100 % fatal if timely intervention of appropriate wound management and Anti Rabies Prophylaxis is not given to the animal bite victims. About 96% of the mortality and morbidity is associated with dog bites. How to cite this article:Shewale A, Nale T, Daptardar M, Tiwari S. A Case for Pre-Exposure Prophylaxis of High-Risk Groups against Rabies in India. J Commun Dis 2021; 53(1): 110-116. DOI: https://doi.org/10.24321/0019.5138.202118

In third world countries like India, women play a vital role in building and maintaining the family and the society. Lymphatic Filariasis (LF) among married women may inflict a deep impact on the society. Present study was focused to study the impact of LF on married women of some rural areas of Bankura district in West Bengal, India. Night blood-samples of 1202 married women were examined to detect the presence of microfilariae. They were examined clinically and also asked for any hidden filarial manifestation. Affected subjects were also interrogated to understand the impact of LF on their lives. Microfilaria rate, mean microfilaria density and disease rate among the married women of the area were assessed as 6.16%, 10.89% and 11.98% respectively. 95.83% of the diseased subjects were of opinion that the disease had imposed some or many adverse effects on their lives. The diseased women suffer from disability, loss of efficiency and social stigma. They are often neglected and abstain themselves from intimating their problems to the family members and seeking help for various reasons. Awareness level is poor and presumably the situation is same in the rural areas of other under developed and developing countries.

Background: Mental health care professionals across the globe should be prepared to contain the spread of COVID-19 among clients with mental illness and should adopt appropriate strategies to manage them effectively. Objective: The objective of this review was to summarize the impact of COVID-19 pandemic on mental health delivery. Methods: A comprehensive literature search was done to identify the effect of COVID-19 global pandemic in mental health delivery. Articles addressing mental health concerns of COVID-19 and its impact on preexisting mental illness and mental health care delivery, available free download in English language were included. A total of nine primary studies published from the onset of COVID-19 until 15th July 2020 were referred to prepare this narrative review. Result: There is evidence that patients with preexisting mental illnesses shows increase in stress, anxiety, sleep disturbances and COVID-19 related delusions and hallucinations during this global pandemic. The proposed drug treatment for COVID-19 and the imposed restrictions on the public to prevent the spread of the disease had resulted in exacerbation of existing mental illness or triggered new mental illness. Conclusion: There should be more research coming up to understand the real effect of COVID-19 on mental health care delivery and possible alternatives to global mental health delivery at the time of global pandemic.