The intellectual developmental disorder (IDD) is a disruption of the neurodevelopment which is characterized by a decrease in the ability for reasoning and understanding abstract and complex information. IDD can occur either isolated or in conjunction with other neurodevelopmental disorders such as autism, motor disruptions, sensorial disruptions, dreaming and feeding disruptions. The objective of the present communication is to expand the knowledge about the phenotype-genotype relationship so far scarcely described in variants of the KMT5B gene, and also to contribute to the understanding of the clinical implications of neurodevelopmental disorders. A clinical case is presented of a female child referred for medical consultation due to maturational delay. Her medical history included a prenatal echography diagnostic of intrauterine growth delay. During physical examination a cephalic perimeter of -2 SD and slight dysmorphias were observed as positive signs. In addition, her reddish hair color, very white skin, hypoplasia of the nails, and an irregular border café-au-lait spot on the left iliac fossa were particularly noticeable. A molecular genetic study for genes involved in autism spectrum disorder was requested. A variant of uncertain significance was detected in the KMT5B gene. The phenotype presented by the patient contributes to the so far scarce description of the genotype-phenotype relationship of KMT5B gene variants. It is proposed to extend the phenotypic characterization of the gene by including information on the alteration in epigenetic regulation and neighbor genes that share the locus of the gene under study. Key words: autism, dominant, intellectual disability in development, KMT5B gen, neurodevelopment

Corn is used to massively produce food for humans and domestic animals with grains of various taxonomic entities or races. For domestic ruminants, the whole plant is also used as forage. In Argentina, both corn grain and whole-plant silage are used for beef and dairy cattle production. This paper aimed to develop the history and perspectives of corn grown for grain and silage, focusing on plant breeding. The importance of corn fodder in its two variants (grain and whole-plant silage) has varied over time. We emphasize herein the importance of the specific genetic breeding of corn used for whole-plant silage to achieve higher yield potential and nutritional value than grain hybrids. The four population genetic structures used over time as cultivars, which determined the evolution of the technological process of selection and breeding, were analyzed. Based on the research carried out, seed companies have incorporated our protocols into their development and breeding programs. The contribution of selection and breeding in Argentina was effective in transforming the corn plant into ruminant feed, and this will increase with the development of specific silage hybrids. Key words: cultivars, corn fodder, plant breeding

El Dr. Mendel hizo descubrimientos que ni él siquiera imaginó la trascendencia

ALAG 2021. XVIII Congreso Latinoamericano de GenéticaLIV Reunión Anual de la Sociedad de Genética de ChileXLIX Congreso Argentino de GenéticaVIII Congreso de la Sociedad Uruguaya de GenéticaI Congreso Paraguayo de GenéticaV Congreso Latinoamericano de Genética Humana

ALAG 2021. XVIII Congreso Latinoamericano de GenéticaLIV Reunión Anual de la Sociedad de Genética de ChileXLIX Congreso Argentino de GenéticaVIII Congreso de la Sociedad Uruguaya de GenéticaI Congreso Paraguayo de GenéticaV Congreso Latinoamericano de Genética Humana