Fibroblast growth factor receptor 2 (FGFR2) is a receptor tyrosine kinase that is involved in many human cancers such as intrahepatic cholangiocarcinomas and hepatocellular carcinomas. The clinically acquired FGFR2 N549H/K mutations make the treatment of Infigratinib ineffective. Here, molecular docking, multiple-replica molecular dynamics (MD) simulations, and binding free energy calculations were used to reveal the mechanism of Infigratinib resistance to the FGFR2 N549H/K mutants. MD simulations indicated that both N549H/K mutations disrupt the local hydrogen bonds or salt bridges formed by His544, Asn549, Glu565, and Lys641. Binding free energy calculation results suggested that both the decrease of van der Waals interactions and electrostatic interaction are responsible for weakening the binding affinity of Infigratinib to the FGFR2 N549H/K mutants. Residue-based energy decomposition analysis further showed that the interactions of Infigratinib with key residues Leu487, Glu565, Ala567, Gly570, and Leu633 become significantly weaker in the N549H/K mutants compared to the wild-type kinase. We anticipate that our results will provide a useful guide to design potential inhibitors against the FGFR2 N549H/K mutants.

Uniform filler dispersion and fillers, such as nanomaterials, with distinct but superior qualities compared to the typical matrix component can be used to create high performance composites. The current study used molecular dynamics simulations to investigate the effect of graphene reinforcement on the mechanical properties of Kevlar/Diglycidyl Ether of Bisphenol-A (DGEBA). Diethyl toluene diamine (DETDA) serves as the curing agent for DGEBA, and graphene is randomly reinforced at 1, 1.5, and 2 weight percent in the DGEBA/DETDA epoxy matrix. A layered (epoxy-Kevlar-epoxy, EKE) is constructed by maintaining Kevlar fibre in horizontal position in between the graphene-reinforced DGEBA/DETDA as illustrated in the figure. Energy minimization, geometry optimization, and dynamics are used to further stabilise the constructed structure. The method of constant strain is used to determine mechanical parameters. The MD simulation revealed that mechanical properties increased with increasing graphene content, with 21.42%, 36.47%, and 42.49% for 1, 1.5, and 2 weight percentages of graphene, respectively, when compared to pure EKE. The increasing trends in elastic moduli corroborate the experimental findings. The ultimate strength increases as graphene content increases.

Drug nanofibers play a crucial role in ameliorating therapeutic effects, reducing toxicity, and increasing the bioavailability of drugs. This study was aimed at the fabrication of isotretinoin-loaded MMT-reinforced bi-polymeric (PAN/PU) nanofibers with varying concentrations of isotretinoin. In this study, montmorillonite (MMT)-reinforced cross-linked polyacrylonitrile and pullulan nanofibers combined with varying amounts of isotretinoin were fabricated through an electrospinning approach and investigated for their drug permeation potential. PAN-PU nanofibers were successfully integrated with the isotretinoin. The incorporation of isotretinoin into the nanofibrous structure was confirmed by FTIR and XRD. TGA study indicated the stability of the fabricated nanoparticles. The SEM results showed the beaded and smooth morphology of nanofibers. Formulation with a higher drug concentration had a non-significantly (p > 0.05) higher swelling ratio. Drug-loaded polymeric nanofiber erodes at a slower rate as compared to drug-free nanofibers. The ex-vivo permeation study of nanofibers revealed that the drug was not released all at once, but rather gradually and consistently over the period of 24 h, indicating a controlled release of the drug. In addition, the drug concentration in the nanofibers affected the permeation of the drug. According to the findings, isotretinoin-loaded MMT-reinforced bi-polymeric (PAN/PU) nanofibers with varying concentrations of isotretinoin were successfully fabricated. The fabricated nanofibers (PAN/PU) showed a promising potential for controlled permeation of drugs through rabbit skin.

A nanoparticle-based drug delivery technology could develop combination cancer therapy more effectively. However, because of inadequate drug delivery into tumor cells, the cancer therapeutic efficiency of nanomedicines is diminished. PEGylated poly(α-lipoic acid) copolymers with (mPEG-PLA) were fabricated and used as pH/reductive responsive nanovesicles to administer Gefitinib (GFT) and doxorubicin (DOX) for the treatment of ovarian cancer. The amphiphilic polymers mPEG-PLA may be efficiently incorporated on DOX and GFT to fabricate DOX and GFT coloaded nanoparticles (DOX@GFT-NPs) and self-assembled into an aqueous solution. The DOX@GFT-NPs released more DOX and GFT after being prepared to respond to pH and reduction stimuli. The outcomes of confocal laser scanning microscopy and flow cytometry findings, the SKOV3 ovarian cancer cells quickly fascinated the dual drugs-coloaded nanoparticles and drugs released intracellularly accumulated. DOX@GFT-NPs triggered cell death and demonstrated synergistic therapeutic benefits in SKOV3 cells. Results showed that the nanoparticles efficiently trigger apoptosis in SKOV3 ovarian cancer cells using morphological staining (acridine orange/ethidium bromide (AO/EB) and HOECHST 33342 nuclear staining). These outcomes show that using pH and reduction stimuli on mPEG-PLA copolymer to treat ovarian cancer is a promising approach.

Alkali treatment followed by alkalinized hydrogen peroxide delignification yielded 73.90% cellulose from Ensete ventricosum pseudo stem fibre, with parameters optimized using response surface methodology. The optimal reaction parameters were 157 min, 73 °C, and 3.8% NaOH concentration. Thermogravimetric analysis (TGA), X-ray diffraction (XRD), Fourier transfer infrared (FTIR), and scanning electron microscopy were used to examine the thermal properties, crystal structure, chemical structure, and morphological structure of isolated cellulose (SEM). Based on the findings, cellulose has a rod-like shape. The XRD results revealed that the crystallinity index of cellulose increased from 65 to 75% when compared with raw E. ventricosum pseudo stem fibre (Ensete fibre). The resultant cellulose demonstrated relatively higher thermal stability than the unprocessed ensete fibre, according to the thermogravimetric examination. When compared to raw ensete fibre, FTIR analysis revealed that cellulose had a modified chemical functional structure, which suggested that alkali and alkalized hydrogen peroxide treatments had altered the chemical structure of cellulose. As a result of the isolated cellulose’s high yield, high crystallinity index, good thermal stability, and morphological structure, cellulose nanocrystals can be extracted.

We, the Editor and Publisher of the Journal Of Experimental Nanoscience, have retracted the following article, which is part of the Special Issue titled Adaptive Nanotechnology for Environmental Sustainability: Dong Sun & Yong Wei (2023) Image processing algorithm for mechanical properties testing of hightemperature materials based on time‐frequency analysis, Journal of Experimental Nanoscience, 18:1, DOI: 10.1080/17458080.2023.2170357 Following publication, concerns were raised about the peer review and decision‐making processes for this special issue. After an investigation by the Taylor & Francis Publishing Ethics & Integrity team, in full cooperation with the Editor‐in‐Chief, it was confirmed that the article was not reviewed appropriately, in line with the Journal’s peer review standards and policy. As the stringency of the peer review process is core to the integrity of the publication process, the Editor and Publisher have decided to retract the article. The authors have been informed of this decision. We have been informed in our decision‐making by our editorial policies and the COPE guidelines. The retracted articles will remain online to maintain the scholarly record, but they will be digitally watermarked on each page as ‘Retracted’.

We, the Editor and Publisher of the Journal Of Experimental Nanoscience, have retracted the following article, which is part of the Special Issue titled Adaptive Nanotechnology for Environmental Sustainability: Nan Li, Shuwen Yang & Yongming Hua (2023) Exploration on inheritance and innovation of material technology and material culture in folk arts, Journal of Experimental Nanoscience, 18:1, DOI: 10.1080/17458080.2023.2170360 Following publication, concerns were raised about the peer review and decision-making processes for this special issue. After an investigation by the Taylor & Francis Publishing Ethics & Integrity team, in full cooperation with the Editor-in-Chief, it was confirmed that the article was not reviewed appropriately, in line with the Journal’s peer review standards and policy. As the stringency of the peer review process is core to the integrity of the publication process, the Editor and Publisher have decided to retract the article. The authors have been informed of this decision. We have been informed in our decision-making by our editorial policies and the COPE guidelines. The retracted articles will remain online to maintain the scholarly record, but they will be digitally watermarked on each page as ‘Retracted’.

We, the Editor and Publisher of the Journal Of Experimental Nanoscience, have retracted the following article, which is part of the Special Issue titled Adaptive Nanotechnology for Environmental Sustainability: Ping Liu & Yang Li (2023) Ecological technology of green building in the initial stage of design based on BIM technology, Journal of Experimental Nanoscience, 18:1, DOI: 10.1080/17458080.2023.2170355 Following publication, concerns were raised about the peer review and decision-making processes for this special issue. After an investigation by the Taylor & Francis Publishing Ethics & Integrity team, in full cooperation with the Editor-in-Chief, it was confirmed that the article was not reviewed appropriately, in line with the Journal’s peer review standards and policy. As the stringency of the peer review process is core to the integrity of the publication process, the Editor and Publisher have decided to retract the article. The authors have been informed of this decision. We have been informed in our decision-making by our editorial policies and the COPE guidelines. The retracted articles will remain online to maintain the scholarly record, but they will be digitally watermarked on each page as ‘Retracted’.