Menopause, cessation of woman's reproduction otherwise can happen early by hysterectomy might need therapeutic attention, as it disturbs psychosomatic health by interruption in the hormonal physiology. Herbs rich in phytoestrogens like Convolvulus pluricaulis Choisy, known as Shankhapushpi in Ayurveda, are better nonhormonal alternatives to manage such conditions. The objective of the study was to evaluate the effect of C. pluricaulis in posthysterectomy menopausal syndrome. In this randomized controlled pilot trial, 30 women who underwent hysterectomy (before attaining natural menopause) meeting the inclusion criteria with a minimum menopause rating scale (MRS) score of 5 and a Modified Kupperman's Index (MKI) score of 7, were randomized into two groups. 15 subjects of the control group received Asparagus racemosus Willd powder, and 15 subjects of the interventional group received C. pluricaulis powder, 6 g twice daily, respectively, after food with lukewarm water for a period of 45 days. Study outcome was evaluated through primary measures MRS, MKI, and Menopause-Specific Quality of Life (MS-QoL) on baseline, 15th, 30th, and 45th day, whereas Serum estrogen and secondary measure Hamilton Anxiety Rating Scale (HARS) on baseline and 45th day. Statistical results were expressed through Independent and Dependent t-tests. Study results revealed that both interventions were comparable and each produced significant improvement (P < 0.001) in MRS, MKI, MS-QoL, and HARS. C. pluricaulis has shown nonsignificant results in improving the serum estrogen levels (P = 0.334) compared to A. racemosus (P < 0.001). C. pluricaulis was beneficial in managing posthysterectomy menopausal syndrome, assessed through MRS, MKI, MS-QoL, and HARS. It was also helpful in maintaining stable estrogen levels, suggesting its possible efficacy as a nonhormonal herbal medicine.

Endometrial cancer has been regarded as one of the most common gynecological malignancies in high-income nations. A wide range of genetic, environmental, and lifestyle-related factors has been identified in the causation of endometrial cancers among women. Acknowledging the rising incidence, associated mortality, and the presence of multiple lifestyle-related factors in the causation of endometrial cancer, we must adopt targeted public health interventions to minimize the impact of these attributes. In conclusion, multiple lifestyle-related factors interact synergistically and significantly contribute to the incidence of endometrial cancer. The need of the hour is to adopt a multisectoral approach to effectively mitigate the consequences of lifestyle-related factors.

Cancer of endometrium is among the most common female malignancies in developed nations. Usually, because of awareness related to complaints of postmenopausal bleeding and availability of various diagnostic modalities, endometrial cancer has a favorable prognosis. The aim of this study is to determine how accurate the contrast-enhanced magnetic resonance imaging (MRI) is for preoperative staging of uterine cancer considering final histopathological report as gold standard. In this retrospective study done in a tertiary care center, 50 patients with histopathological diagnosis of endometrial carcinoma were included, operated at our center between January 2024 and December 2024. Various prognostic factors such as invasion of myometrium and cervical stroma, metastasis to the lymph nodes (LNs), and extrauterine spread (EUS) were analyzed preoperatively with contrast-enhanced MRI reported by a single radiologist and then compared with final histopathology report. Statistical parameters such as accuracy (Ac), sensitivity (Sn), specificity (Sp), positive predictive value (PPV), and negative predictive value (NPV) of MRI were assessed for each factor. The Sn, Sp, Ac, PPV, and NPV of myometrial invasion (MI) diagnosed with MRI were 62.5%, 80.77%, 72%, 75%, and 70%, and these values for cervical invasion were 40%, 100%, 94%, 100%, and 93.75%, respectively. Similar values for LN metastasis were 33.3%, 95.5%, 88%, 50%, and 91.3% and for EUS were 25%, 97.83%, 92%, 50%, and 93.75%, respectively. MRI is a sensitive tool for MI with good Ac and Sp for the diagnosis of cervical stromal invasion and LN metastasis before surgery and helps the clinician to plan the surgery accordingly.

[This corrects the article on p. S12 in vol. 17, PMID: 41767293.].

ABSTRACTIntroduction:Breast cancer is a leading cause of cancer-related deaths among women worldwide. Prior to metastasis, carcinomas undergo epithelial–mesenchymal transition (EMT), a process wherein cancer cells acquire mobility, form tumor buds (TBs), and invade the stroma. The presence and number of TBs are directly proportional to tumor invasion and metastasis. By scoring TBs and using immunohistochemistry (IHC) to detect EMT process, we can identify patients with poor prognosis after surgical resection. This enables early recognition of patients requiring aggressive treatment and follow-up.Aim:The aim of this study was to propose an algorithm for measuring TB and to establish the correlation between TB with EMT markers expression and main clinical parameters.Materials and Methods:A retrospective analytical study in an urban tertiary health care center involving 47 cases of invasive breast carcinomas. TB was assessed in Haematoxylin & Eosin stained tissue sections followed by IHC with EMT markers. Association between TB, EMT markers, and main clinical parameters was statistically analyzed using the Chi-square test.Results:Among 47 cases, 30 had mean-low TB score (≤4/ 10HPF) and 17 had mean-high TB score (>4/10 HPF). Tumors with high TB scoring showed strong SNAIL, TWIST, and N-cadherin expression. Tumors with low TB scores showed high E-cadherin expression and low SNAIL, TWIST, and N-cadherin expression.Conclusion:The study established a positive correlation between TB and EMT markers. High TB scores are significantly associated with lymphovascular invasion, lymph node metastasis, and higher tumor grading. Using TB score and EMT markers in breast cancer management can facilitate patient-centered approach.

Menopause marks a significant transition in a woman's life, characterized by hormonal changes that influence metabolism, cardiovascular health, and overall well-being. As women approach menopause, managing these changes becomes crucial for maintaining health and quality of life. Among various dietary interventions, intermittent fasting has emerged as a promising strategy, not only for weight management but also for addressing hormonal imbalances and mitigating age-related risks such as cardiovascular disease and cognitive decline.

Body mass index (BMI) rises in correlation with endometrial cancer incidence as obesity rates among women have risen in recent years. In this study, we sought to evaluate the relationship between BMI and the perimenopausal ladies' aberrant and normal endometrial pathology. We also evaluated the correlation of transvaginal ultrasonography findings with histopathological findings. A prospective analytical study was conducted in a Tertiary care centre of Northern India over a period of 12 months from June 2022-May 2023 on women aged 40-55 years with Abnormal Uterine Bleeding (AUB) according to PALM-COEIN criteria. Patients were divided into two groups according to endometrial biopsy findings; women in group 1 were diagnosed with endometrial hyperplasia or carcinoma, while women in group 2 had normal endometrium, according to WHO classification. BMI, Endometrial biopsy pathology and transvaginal ultrasonography findings were noted. Data was analysed using SPSS version 24.0. Out of 72 patients, 22 patients had histopathological findings of Adenocarcinoma (3, 13.6%) and endometrial hyperplasia (19, 86.4%) and rest 50 patients had normal proliferative (13, 26%). On the basis of BMI, 51.5% (32/72) were overweight, 31.9% (23/72) were of Normal BMI, 11.1% (15/72) were Obese. The mean age in Group A and B was 52.37 ± 2.68 and 48.74 ± 7.98 respectively (P value- 0.003). Significant association between obesity and endometrial hyperplasia or carcinoma (P value-0.033). Correlation of Transvaginal Ultrasound (TVS) findings with that of histopathology was statistically significant (P value-0.002). Adenomyosis and Polyp and 100% correlation percentage on TVS and Histopathology. There is a direct link between a high body mass index and AUB due to endometrial hyperplasia. Importance of physical activity as a preventative factor against AUB, endometrial cancer, and hyperplasia should be promoted. TVS is also a suitable diagnostic technique for the assessment of AUB as an initial procedure.