Adam M. Tuttle, Matthew B. Pomaville, Katherine C. Delgado, Kevin M. Wright, and Alex V. Nechiporuk (see pages [6835–6847][1]) Most cancer drugs have significant toxic side effects. One such effect is chemotherapy-induced peripheral neuropathy, which results in numbness, burning, tingling

Sophie Belin, Bruce A. Maki, James Catlin, Benjamin A. Rein, and Gabriela K. Popescu (see pages [5672–5680][1]) NMDA receptors (NMDARs) are uniquely suited to mediate activity-dependent synaptic activity because their activation requires both ligand (glutamate) binding and membrane

Grant P. Higerd-Rusli, Matthew Alsaloum, Sidharth Tyagi, Nivedita Sarveswaran, Mark Estacion, et al. (see pages [4794–4811][1]) Neuronal function, from synaptic integration to spike output, depends heavily on the type, expression level, and localization of ion channels in the plasma membrane.

Nina L. Kikel-Coury, Lauren A. Green, Evan L. Nichols, Abigail M. Zellmer, Sanjana Pai, et al. (see pages [6617–6636][1]) The brain and spinal cord are surrounded and protected by a multilayered sheath composed of specialized extracellular matrix (basement membrane), glial processes (forming the

In “This Week in the Journal,” which appeared on page [5343][1] of the July 8, 2020 issue, the title of the section How Relaxin-3 Inhibits Eating appeared incorrectly. The section title should instead read: How Relaxin-3 Increases Eating . The online version has been corrected. [1]: /lookup/

Diana J. Ixmatlahua, Bianca Vizcarra, Gisela Gómez-Lira, Isabel Romero-Maldonado, Franco Ortiz, et al. (see pages [4661–4672][1]) Throughout most of the twentieth century, electrical synapses were thought to be rare in the mammalian brain. The discovery, subsequent immunolabeling, and knockout

Jennifer K. Roebber, Stephen D. Roper, and Nirupa Chaudhari (see pages [6224–6232][1]) Taste perception begins with depolarization of neuroepithelial cells in taste buds. Sugars, amino acids, and bitter substances activate G-protein-coupled receptors in type II taste-bud cells. This leads to

Henry Alitto, Daniel L. Rathbun, Jessica J. Vandeleest, Prescott C. Alexander, and W. Martin Usrey (see pages [5697–5710][1]) Thalamocortical neurons exhibit different spike patterns depending on whether T-type calcium channels are activated. Subthreshold depolarization after a period of

The editors wish to express concern about the article by Haihong Chen, Hao Ji, Ming Zhang, Zude Liu, Lifeng Lao, Chao Deng, Jianwei Chen and Guibin Zhong, entitled “An Agonist of the Protective Factor SIRT1 Improves Functional Recovery and Promotes Neuronal Survival by Attenuating Inflammation

In the article “Fibroblast Growth Factor 2 in the Dorsomedial Striatum Is a Novel Positive Regulator of Alcohol Consumption” by Oren Even-Chen, Yossi Sadot-Sogrin, Ohad Shaham, and Segev Barak, which appeared on pages [8742–8754][1] of the September 6, 2017 issue, an incorrect coronal