To evaluate maternal sociodemographic factors and adverse pregnancy outcomes associated with hepatitis C virus (HCV) infection during pregnancy in a large population of live births. Retrospective analysis of the UnitedStates (US) Centers for Disease Control and Prevention Natality Live Birth database (2016-2021). All births were eligible for inclusion. Deliveries with missing data on HCV infection were excluded. Multiple sociodemographic factors and adverse pregnancy and neonatal outcomes were compared between pregnancies complicated by maternal HCV infection and those without HCV. Multivariable logistic regression was utilized to evaluate the association of sociodemographic factors with HCV and adjust outcomes for potential confounders. Of the 22,604,938 live births included, 107,761 (0.48 %) were complicated by maternal HCV. Patients with HCV in pregnancy were more likely to be advanced maternal age, have Medicaid insurance, or smokers. In addition, HCV in pregnancy was associated with higher risks of concurrent infections with hepatitis B virus, syphilis, gonorrhea, or chlamydia. HCV was associated with an increased risk of preterm birth<37weeks, low birthweight, congenital anomalies at birth, low 5-min Apgar scores, NICU admission, antibiotic treatment for suspected neonatal sepsis, as well as immediate and prolonged ventilation. Based on this recent, large US population cohort, HCV in pregnancy is more commonly associated with certain sociodemographic factors and several adverse pregnancy and neonatal outcomes. These data are an important step in the attempt to identify at-risk patients and employ strategies to better manage and optimize care for these pregnancies.

Global guidelines increasingly support breastfeeding among women living with HIV (WLWH) underoptimized conditions. However, outcome data from high-resource settings remain limited. We retrospectively analyzed WLWH who delivered at Charité-Universitätsmedizin Berlin between 2017 and 2023. Eligibility for breastfeeding required VL<50 cop/mL. Of 409 WLWH, 365 (89.2 %) were eligible and 77 (18.8 %) initiated breastfeeding. No case of mother-to-child transmission (MTCT) was observed. Sustained viral suppression and ART adherence were key. Exclusive breastfeeding was associated with longer duration (p=0.001), midwifery carepromoted exclusivity (p=0.009), and vaginal delivery waslinked to longer duration (p=0.005). Breastfeeding with VL<50 cop/mL appears safe in high-resource settings. Findings support individualized counseling, close monitoring, and multidisciplinary care. The increasing breastfeeding trend reflects a shift in clinical practice.

To describe maternal and perinatal outcomes in patients with BMI≥30 kg/m2 by BMI class and gestational weight gain. Retrospective review of singleton pregnancies with pre-pregnancy BMI≥30 kg/m2 who received care at our institution between January 1, 2016 and December 31, 2021. Patients were divided into three categories based on BMI (kg/m2): Class I (BMI 30.0-34.9), Class II (BMI 35-39.9), and Class III (BMI≥40) obesity. For gestational weight gain analysis, pregnancies were stratified into three groups: <11 pounds, 11-20 pounds, and >20 pounds. Maternal demographics and outcomes were compared using chi-square analysis, analysis of variance, nonparametric tests, and multivariable regression analysis. Of 641 patients included, 299 (46.6 %) were in Class I, 209 (32.6 %) in Class II, and 133 (20.7 %) in Class III. Readmission within 6weeks postpartum, the only outcome found to have a significant difference between BMI categories, was higher in the Class III group (p=0.01). One hundred sixty-two (25.3 %) patients gained <11 pounds, 164 (25.6 %) gained 11-20 pounds, and 313 (48.8 %) gained≥20 pounds. Greater gestational weight gain was associated with increased rates of cesarean delivery (p<0.001), higher quantitative blood loss (p=0.006), longer length of hospitalization (p=0.03), and higher birthweights (p<0.001). This represents a unique and actionable opportunity for clinicians to counsel and support their patients in adhering to optimal weight gain targets throughout their pregnancy. Future studies are needed todetermine the optimal gestational weight gain recommendations for obese patients.

To determine Dysphoric Milk Ejection Reflex (DMER) incidence. Secondary objectives were to describe the symptom profiles and patient characteristics of DMER and assess DMER familiarity. A prospective observational study of people who initiated breastfeeding after delivery between December 2022 and May 2023 at two hospitals in New York. Participants filled out an Initial Survey, assessing prior DMER familiarity, and recurring DMER Symptoms Surveys, assessing symptom presence, severity, and transiency. Medical records were reviewed for patient demographics and clinical history. Descriptive and basic inferential statistics were performed. A p<0.05 was considered statistically significant. Based on the DMER definition utilized, incidence was 26.9 % (n=21), and symptom severity was mostly very mild to moderate. Those with DMER had similar baseline characteristics to those without, apart from a significantly higher rate of having delivered via cesarean section (71.4.0 vs. 33.3 %, p<0.01). Among the 55 patients who completed the initial survey, 61.8 % were unfamiliar with the condition. DMER is described as brief, abrupt, negative emotions experienced by breastfeeding individuals prior to milk letdown. We found that more than 1 in 4 participants screened positive. Future research could better define, quantify, qualify, and publicize this condition to inform clinical practices and facilitate successful breastfeeding relationships.

The retention of academic faculty, particularly in the field of Obstetrics and Gynecology (OB/GYN), has become a growing challenge in the post-COVID era. The healthcare landscape has been dramatically altered, leading to a "Great Exit" where a large number of faculty members are resigning or retiring early. This phenomenon is not just a financial burden as recruitment costs have skyrocketed, but also poses a threat to the stability and reputation of academic institutions. In this review article, we explore the underlying causes of faculty attrition, the predictors of resignation, and propose comprehensive strategies to retain talented faculty members. We highlight the importance of mentorship, career development opportunities, and fostering a supportive work environment that aligns with both institutional and individual values. The goal is to create a sustainable framework for faculty engagement that strengthens the academic mission and improves clinical outcomes.

Endometriosis, a condition in which endometrial-like tissue grows outside of the uterus, is a common disorder among women of reproductive-age. The objective of the study is to examine the associations between endometriosis in pregnancy and adverse maternal and newborn events. Data from the 1999-2019 Healthcare Cost and Utilization Project, Nationwide Inpatient Sample, which is from the United States, were used to perform a retrospective cohort study. Associations between endometriosis and maternal and newborn outcomes were examined using multivariate logistic regression models adjusted for baseline maternal characteristics. We identified 14,956 individuals with endometriosis and 16,911,497 individuals without endometriosis. The prevalence of endometriosis in pregnancy rose substantially from 34.9 to 160.6 per 100,000 births between 1999 and 2019. Individuals with endometriosis were more likely older in age, of Caucasian ethnicity, belonged to higher income quartiles, had private insurance, smoked, and were obese. Endometriosis in pregnancy was associated with greater odds of pre-eclampsia, gestational diabetes, placenta previa, placental abruption, preterm birth, chorioamnionitis, and postpartum hemorrhage. Growth restriction and congenital anomalies were more frequent among newborns born to individuals with endometriosis. Endometriosis in pregnancy renders individuals and their newborns at greater risk for poor outcomes in pregnancy. Hence, it is prudent for obstetrical care providers to be aware of the adverse events associated with endometriosis and to closely follow the pregnancies of women with this condition.

The aim of this study was to investigate if gestational weight gain was altered during the early COVID-19 pandemic period. This a retrospective cohort study evaluating gestational weight gain among individuals delivering during the early COVID-19 pandemic epoch (March 10-December 31,2020) compared to temporally matched pre-pandemic (matched months in 2018 and 2019) controls using electronic medical record data from a large tertiary care hospital. The primary outcome was gestational weight gain defined as a categorical measure representing below, meeting, or above Institute of Medicine (IOM) criteria with further adjustment for gestational age at delivery. The early-pandemic exposure group was also categorized by gestational age at the start period (<14weeks' and 14-20weeks') to assess if duration of exposure affected gestational weight gain risks with the use of multinominal logistic regression. Among 5,377 individuals 3,619 (67.3 %) and 1,758 (32.7 %) were in the pre and early pandemic epochs respectively. Overall, 934 (17.4 %) individuals gained below recommended, 1,280 (23.8 %) met recommendations, and 3,163 (58.8 %) gained above IOM recommended gestational weight gain. Compared to the pre-pandemic epoch, the early pandemic period was not associated with weight gain below (OR 1.06, 95 % Cl 0.89-1.27) or above (OR 1.03, 95 % Cl 0.89-1.19) IOM recommendations. This was also true when the early pandemic group was stratified based on gestational age at the start of the early pandemic period (<14weeks' and 14-20weeks'). This study demonstrated no significant difference in maternal weight gain between pre and early COVID-19 pandemic periods.