The femoral neck is the most vulnerable site for fractures within the hip joint. Due to its complex three-dimensional structure and special blood supply mechanism, the treatment of femoral neck fractures is difficult and the healing probability is low. Using computers to accurately and automatically locate the femoral neck axis can detect the density of femoral neck, the neck-shaft angle and the anteversion angle, which effectively assists in the prevention and treatment of femoral neck fractures. Additionally, the traditional femoral neck axis positioning schemes have limitations in accuracy, automation and assistance to bone density measurement. Therefore, this paper proposes a new fully automatic femoral neck axis positioning method. First, the coronal plane's three-dimensional reconstruction highlights the details of the target bone, and then designs a coarse localization module based on multi-scale template matching to obtain the rough range of the femoral neck axis. Then, a detailed localization module based on the femoral neck virtual slices is used to obtain the contour centers and accurately locates the three-dimensional femoral neck axis. This method has been validated in comparison with the manual measurement method. Experimental results revealed that the extracted femoral neck axis in this study can achieve automation, ensure accuracy, and avoid subjective effects effectively and has the potential value to be applied in the prevention and treatment of femoral neck fractures.

Cancer is an invasive and malignant growth of cells and is known to be one of the most fatal diseases. Its early detection is essential for decreasing the mortality rate and increasing the probability of survival. This study presents an efficient machine learning approach based on the state vector machine (SVM) to diagnose and classify tumors into malignant or benign cancer using the online lymphographic data. Further, two types of neural network architectures are also implemented to evaluate the performance of the proposed SVM-based approach. The optimal structures of the classifiers are obtained by varying the architecture, topology, learning rate, and kernel function and recording the results' accuracy. The classifiers are trained with the preprocessed data examples after noise removal and tested on the unknown cases to diagnose each example as positive or negative. Further, the positive cases are classified into different stages including metastases, malign lymph, and fibrosis. The results are evaluated against the feed-forward and generalized regression neural networks. It is found that the proposed SVM-based approach significantly improves the early detection and classification accuracy in comparison to the experienced physicians and the other machine learning approaches. The proposed approach is robust and can perform sub-class divisions for multipurpose tasks. Experimental results demonstrate that the two-class SVM gives the best results and can effectively be used for the classification of cancer. It has outperformed all other classifiers with an average accuracy of 94.90%.

Estimation of knee contact force (KCF) during gait provides essential information to evaluate knee joint function. Machine learning has been employed to estimate KCF because of the advantages of low computational cost and real-time. However, the existing machine learning models do not adequately consider gait-related data's temporal-dependent, multidimensional, and highly heterogeneous nature. This study is aimed at developing a multisource fusion recurrent neural network to predict the medial condyle KCF. First, a multisource fusion long short-term memory (MF-LSTM) model was established. Then, we developed a transfer learning strategy based on the MF-LSTM model for subject-specific medial KCF prediction. Four subjects with instrumented tibial prostheses were obtained from the literature. The results showed that the MF-LSTM model could predict medial KCF to a certain high level of accuracy (the mean of ρ = 0.970). The transfer learning model improved the prediction accuracy (the mean of ρ = 0.987). This study shows that the MF-LSTM model is a powerful and accurate computational tool for medial KCF prediction. Introducing transfer learning techniques could further improve the prediction performance for the target subject. This coupling strategy can help clinicians accurately estimate and track joint contact forces in real time.

Accurate segmentation of honeycomb lung lesions from lung CT images plays a crucial role in the diagnosis and treatment of various lung diseases. However, the availability of algorithms for automatic segmentation of honeycomb lung lesions remains limited. In this study, we propose a novel multi-scale cross-layer attention fusion network (MCAFNet) specifically designed for the segmentation of honeycomb lung lesions, taking into account their shape specificity and similarity to surrounding vascular shadows. The MCAFNet incorporates several key modules to enhance the segmentation performance. Firstly, a multiscale aggregation (MIA) module is introduced in the input part to preserve spatial information during downsampling. Secondly, a cross-layer attention fusion (CAF) module is proposed to capture multiscale features by integrating channel information and spatial information from different layers of the feature maps. Lastly, a bidirectional attention gate (BAG) module is constructed within the skip connection to enhance the model's ability to filter out background information and focus on the segmentation target. Experimental results demonstrate the effectiveness of the proposed MCAFNet. On the honeycomb lung segmentation dataset, the network achieves an Intersection over Union (IoU) of 0.895, mean IoU (mIoU) of 0.921, and mean Dice coefficient (mDice) of 0.949, outperforming existing medical image segmentation algorithms. Furthermore, experiments conducted on additional datasets confirm the generalizability and robustness of the proposed model. The contribution of this study lies in the development of the MCAFNet, which addresses the lack of automated segmentation algorithms for honeycomb lung lesions. The proposed network demonstrates superior performance in accurately segmenting honeycomb lung lesions, thereby facilitating the diagnosis and treatment of lung diseases. This work contributes to the existing literature by presenting a novel approach that effectively combines multi-scale features and attention mechanisms for lung lesion segmentation. The code is available at https://github.com/Oran9er/MCAFNet .

The extraction of information from images provided by medical imaging systems may be employed to obtain the specific objectives in the various fields. The quantity of signal to noise ratio (SNR) plays a crucial role in displaying the image details. The higher the SNR value, the more the information is available. In this study, a new function has been formulated using the appropriate suggestions on convolutional combination of the longitudinal and transverse magnetization components related to the relaxation times of T1 and T2 in MRI, where by introducing the distinct index on the maximum value of this function, the new maps are constructed toward the best SNR. Proposed functions were analytically simulated using Matlab software and evaluated with respect to various relaxation times. This proposed method can be applied to any medical images. For instance, the T1- and T2-weighted images of the breast indicated in the reference [35] were selected for modelling and construction of the full width at x maximum (FWxM) map at the different values of x-parameter from 0.01 to 0.955 at 0.035 and 0.015 intervals. The range of x-parameter is between zero and one. To determine the maximum value of the derived SNR, these intervals have been first chosen arbitrarily. However, the smaller this interval, the more precise the value of the x-parameter at which the signal to noise is maximum. The results showed that at an index value of x = 0.325, the new map of FWxM (0.325) will be constructed with a maximum derived SNR of 22.7 compared to the SNR values of T1- and T2-maps by 14.53 and 17.47, respectively. By convolving two orthogonal magnetization vectors, the qualified images with higher new SNR were created, which included the image with the best SNR. In other words, to optimize the adoption of MRI technique and enable the possibility of wider use, an optimal and cost-effective examination has been suggested. Our proposal aims to shorten the MRI examination to further reduce interpretation times while maintaining primary sensitivity. Our findings may help to quantitatively identify the primary sources of each type of solid and sequential cancer.

Rehabilitation robots are used to promote structural and functional recovery of the nervous system with repetitive, task-oriented training and have been gradually applied to clinical rehabilitation training. This paper proposes an upper limb exoskeleton rehabilitation robot system that could realize shoulder-elbow-wrist joint rehabilitation training. Firstly, a motion equivalent model was established based on the upper limb movement mechanism, the robot mechanism configuration was designed, and the optimization algorithm and spatial mechanism theory were used to optimize and analyze the structural parameters and human-machine compatibility of the robot, which will guide the design of the robot's model. Then, the robot kinematics were solved, and its maximum motion range, dexterity distribution, and daily motion trajectory were simulated. Finally, a system prototype was built to test the maximum range of robot-assisted human upper limb training by laser tracker, while the pressure of human-machine interaction during training was captured and analyzed by flexible sensors. The results show that the proposed rehabilitation robot could nearly completely cover the range of motion of upper limb joints and meet the needs of trajectory training, and the linear velocity dexterity and angular velocity dexterity in the motion space are maximum 0.55 and 0.89, and the human-machine interaction pressures during the training process are all less than 10kPa. Besides, this paper also conducted a system evaluation based on the fuzzy comprehensive evaluation model, and the evaluation result was 0.39, with an excellent evaluation grade, it indirectly indicates that the robot's overall performance was good.

Accurate segmentation of hepatic vessel is significant for the surgeons to design the preoperative planning of liver surgery. In this paper, a sequence-based context-aware association network (SCAN) is designed for hepatic vessel segmentation, in which three schemes are incorporated to simultaneously extract the 2D features of hepatic vessels and capture the correlations between adjacent CT slices. The two schemes of slice-level attention module and graph association module are designed to bridge feature gaps between the encoder and the decoder in the low- and high-dimensional spaces. The region-edge constrained loss is designed to well optimize the proposed SCAN, which integrates cross-entropy loss, dice loss, and edge-constrained loss. Experimental results indicate that the proposed SCAN is superior to several existing deep learning frameworks, in terms of 0.845 DSC, 0.856 precision, 0.866 sensitivity, and 0.861 F1-score.

Three-dimensional (3D) reconstruction of computed tomography (CT) and magnetic resonance imaging (MRI) images is an important diagnostic method, which is helpful for doctors to clearly recognize the 3D shape of the lesion and make the surgical plan. In the study of medical image reconstruction, most researchers use surface rendering or volume rendering method to construct 3D models from image sequences. The watertightness of the algorithm-reconstructed surface will be affected by the segmentation precision or the thickness of the CT layer. The articular surfaces at femoral ends are often used in biomechanical simulation experiments. The model may not conform to its original shape due to the manual repair of non-watertight surfaces. To solve this problem, a 3D reconstruction method of leg bones based on deep learning is proposed in this paper. By deforming the convex hull of the target, comparing with state-of-the-art methods, our method can stably generate a watertight model with higher reconstruction accuracy. In the situation of target transition structures getting fuzzy and the layer spacing increasing, the proposed method can maintain better reconstruction performance and appear higher robustness. Also, the chamfer loss is optimized based on the rotational shape of the leg bones, and the weight of the loss function can be assigned according to the geometric characteristics of the target. Experiment results show that the optimization method improves the accuracy of the model. Furthermore, our research provides a reference for the application of deep learning in medical image reconstruction.

Globally, respiratory disorders are a great health burden, affecting as well as destroying human lives; pneumonia is one among them. Pneumonia stages can progress from mild stage to even towards deadly if it is misdiagnosed. Misdiagnosis happens as it exhibits the symptoms identical to other respiratory diseases. Respiratory sound (RS)-based detection of pneumonia could be the most perfect, convenient, as well as the economical solution to this serious problem. This paper presents a novel method to detect pneumonia based on RS. This study is carried out over 310 pneumonia RS and 318 healthy RS, recorded from a hospital. The noises from each RS are eliminated using the Butterworth band pass filter and sparsity-assisted signal smoothing algorithm. Approximate entropy, Shannon entropy, fractal dimension, and largest Lyapunov exponent are the nonlinear features, which are extracted from each denoised RS. The extracted features are inputted to support vector machine classifiers to distinguish pneumonia RS and healthy RS. This method discriminates against pneumonia and healthy RS with 99.8% classification accuracy, 99.8% sensitivity, 99.6% specificity, 99.6% positive predictive value, 99.6% F1-score, and area under curve value of 1.0. Future endeavours will be to examine the efficacy of the proposed algorithm to diagnose pneumonia from the real-time RS acquired from a pneumonia patient in a hospital. This proposed work could be a great support to clinicians in diagnosing pneumonia based on RS.

Efficient and reliable diagnosis of craniofacial patterns is critical to orthodontic treatment. Although machine learning (ML) is time-saving and high-precision, prior knowledge should validate its reliability. This study proposed a craniofacial ML diagnostic workflow base on a cephalometric geometric model through clinical verification. A cephalometric geometric model was established to determine the landmark location by analyzing 408 X-ray lateral cephalograms. Through geometric information and feature engineering, nine supervised ML algorithms were conducted for sagittal and vertical skeleton patterns. After dimension reduction, plane decision boundary and landmark contribution contours were depicted to demonstrate the diagnostic consistency and the consistency with clinical norms. As a result, multi-layer perceptron achieved 97.56% accuracy for sagittal, while linear support vector machine reached 90.24% for the vertical. Sagittal diagnoses showed average superiority (91.60 ± 5.43)% over the vertical (82.25 ± 6.37)%, where discriminative algorithms exhibited more steady performance (93.20 ± 3.29)% than the generative (85.98 ± 9.48)%. Further, the Kruskal-Wallis H test was carried out to explore statistical differences in diagnoses. Though sagittal patterns had no statistical difference in diagnostic accuracy, the vertical showed significance. All aspects of the tests indicated that the proposed craniofacial ML workflow was highly consistent with clinical norms and could supplement practical diagnosis.