Engineered magnetoplasmonic nanostructures offer an efficient route to enhance the magneto-optical (MO) activity of materials, greatly improving their practical utility. Especially, three-dimensional (3D) magnetoplasmonic nanostructures offer richer MO properties through multi-mode excitations, providing new paradigms for miniaturized non-reciprocal photonic devices. However, the complex geometrical configurations of 3D nanostructures impose significant fabrication challenges compared to conventional planar nanostructures, which creates substantial obstacles for practical implementation. Here, we present free-standing metallic hole–vertical nanoplate (MH-VNP) nanostructures fabricated by high-precision focused ion beam (FIB) technology on Au/Co/Au trilayers. Under y-polarized excitation, MH-VNPs exhibit an unusual Fano resonance arising from in-phase conductive coupling between the nanoplate and metallic hole, thereby forming 3D currents. This resonance induces strong magnetic field localization, causing a larger Faraday rotation (FR) and enabling FR sign inversion. Systematic modulation of geometric parameters allows precise control of FR magnitude and resonance positions, offering versatile tunability. The self-supported architecture maximizes exposure to the surrounding medium, achieving an exceptional refractive index sensitivity of up to 1500 nm/RIU. Overall, this work demonstrates an environmentally friendly fabrication route for 3D magnetoplasmonic structures, offering a versatile approach for tailoring MO responses in nonreciprocal photonic and sensing applications.

Androgenetic alopecia (AGA) is characterized by progressive follicle miniaturization, excessive inflammation and hair follicle stem cell (HFSC) quiescence. To address these multifactorial challenges, we developed a dissolvable γ-polyglutamic acid (γ-PGA) hydrogel microneedle system (VI@MSN/MNs-DHA) delivering: (1) VEGFR-3 inhibitor (VI) encapsulated in mesoporous silica nanoparticles (MSNs) to remodel lymphatic vessel endothelial hyaluronan receptor 1-positive (LYVE1+) lymphatic networks and thereby reduce anatomical constraints on anagen entry, and (2) docosahexaenoic acid (DHA) to normalize lipid metabolism and oxidative stress. <em>In vitro</em>, VI@MSN/MN-DHA extracts demonstrated multiple bioactivities, including the suppression of lymphatic endothelial tube formation, scavenging of reactive oxygen species, and protection of HFSCs from testosterone-induced injury. <em>In vivo</em>, topical application of VI@MSN/MN-DHA in an AGA mouse model accelerated anagen onset and increased hair regrowth density by 1.37-fold compared to the untreated group. Mechanistically, it is identified that the treatment of VI@MSN/MN-DHA led to the coordinated upregulation of SOX9 and Ki67 in HFSCs, along with restoration of peroxisome proliferator-activated receptor-γ signaling. This study presents a novel strategy that combines lymphatic remodeling and metabolic reprogramming to effectively reactivate HFSCs and promote hair regeneration. The minimally invasive microneedle platform offers a novel microenvironment-engineering paradigm for safe and effective AGA therapy.

Single-crystal diamond has attracted much attention because of its wide bandgap and specific thermal and optical properties, which is suitable for the utilization on integrated photonic devices and power semiconductor devices. However, its extremely high hardness confines the processing ability of micro/nano structures, which is the main determinant of devices performance. Here, multimode patterning methods using ultrafast laser regulated in spatial-domain with high precision are proposed. Through designing of spatial beam phase, specific patterned micro/nano structures ranging from sub-micrometer scale to millimeter scale can be printed on diamond surface with improved efficiency. This provides a facile strategy for the fabrication of programmable patterns with sub-wavelength resolutions. The laser ablation and graphitization result can be precisely predicted by calculating free electron density and validated through patterning experiment. A diamond holographic element is designed and fabricated through the proposed method, which can project the reconstructed holographic image for display applications. This work presents a promising method for preparing of single-crystal diamond-based next-generation semiconductor devices and integrated photonic systems requiring precise light field control.