One Health & Risk Management is a biannual scientific journal for specialists in medical and biological sciences, which was founded in 2019 within the Moldavian Biosafety and Biosecurity Asociation (MDBBA). The journal accepts submissions in Romanian, English, French and Russian, in accordance with current international standards and guidelines. Therefore, One Health & Risk Management Journal will support and publish manuscripts based on scientific evidence on human, animal and environmental health.

Introduction. Biological disease-modifying antirheumatic drugs (bDMARDs), such as tocilizumab (TCZ), are essential for reducing disease activity in moderate to severe rheumatoid arthritis (RA). This study aims to identify clinical and laboratory predictors of a favorable response to TCZ, enabling personalized therapeutic strategies. Material and methods. A longitudinal clinical study in dependent samples included 133 bio-naïve patients (121 women, 12 men, mean age 49.87±13.31 years) with seropositive RA (radiological stages I-III) treated with TCZ and csDMARDs at the Timofei Moșneaga Republican Clinical Hospital. Clinical and laboratory parameters were monitored monthly over a six-month period. Statistical analysis was performed using Spearman’s correlation and multiple regression. The Wilcoxon signed-rank test was applied to compare parameters before and after TCZ treatment. Results. Favorable response predictors included swollen joint counts (ρ=0.59, p<0.01), tender joint counts (ρ=0.40, p<0.01), C-reactive protein (ρ=0.46, p<0.01), ESR (ρ=0.25, p<0.01), platelet count (ρ=0.29, p<0.01), hemoglobin (ρ=-0.26, p<0.01), hematocrit (ρ=-0.23, p<0.01), and age (ρ=-0.49, p<0.01). Regression analysis confirmed the influence of swollen joint counts (ρ=0.30, p<0.001), age (ρ=-0.30, p<0.001), and C-reactive protein (ρ=0.18, p=0.016) on DAS28 reduction. Conclusions. Swollen and tender joint counts, C-reactive protein, and age are key independent predictors of therapeutic success with TCZ after six months of treatment.

Traumatic brain injuries is a significant public health issue in both developed and developing countries. In Georgia, traumatic brain injuries remains one of the leading causes of mortality and disability. Traumatic brain injuries affect families, communities and societies in Georgia and have far-reaching human, social and economic costs, manifested in increased emergency department visits, hospitalizations, disability and deaths.The aim of this study is to retrospectively analyze the epidemiological features of Traumatic Brain Injuries on the example of Medical Centre in Georgia which provides a first level trauma care for patients in the country. Retrospective observational study was conducted from August 1 to October 31, 2018. The study included patients who were admitted with a Traumatic Brain Injuries diagnosis and S00-S09.0 codes (ICD 10). SPSS 20 was used for statistical analysis. A total of 96 TBI-related hospitalizations were studied. 56.3% (n=54) of hospitalized patients were males. The average age of patients was 40.7 years. Furthermore, patients aged 25-44 years were more represented in the number of TBI-related hospitalizations (39.6%). 95.8% of all Traumatic brain injuries hospitalizations were as a result of unintentional injuries. Unintentional falls were shown to be the predominant mechanism of injury accounting for over half of TBI-related hospitalizations (56.2%). The second most common mechanism of injury is the road traffic injury, mostly occurring among males (63.9%). This study offers an insight into understanding the epidemiological features of Traumatic Brain Injuries on the example of the National Medical Center from Georgia.