Abstract Allylic oxidation of alkenes, which converts an allylic methylene group to a carbonyl group, is powerful methodology for the synthesis of unsaturated ketones. Compared with more traditional oxidative reagents, such as stoichiometric oxidants selenium dioxide and chromium(VI), the mild tert ‐butyl hydroperoxide (TBHP) oxidant, when combined with select transition metals, has advantages, especially in large‐scale reactions and natural product syntheses. The success of TBHP as a selective oxidant is due to formation of the tert ‐butylperoxy radical. N‐Substituted 2,3‐dihydro‐4‐piperidones and substituted 4‐pyranone compounds are important intermediates in natural products and drug candidates. 7 In the first total synthesis of dehydroaltenuene B by the Barrett group, the authors found that alpha, beta‐unsaturated ketone, which was the key intermediate, could be obtained by TBHP allylic oxidation of fused cyclic alkene in good yield.

Abstract One of the most efficient methodologies to prepare amines is the addition of organometallic reagents to imines. From a synthetic point of view, the corresponding allylation presents special interest due to the possible transformation of the introduced carbon‐carbon double bond into other functionalities. This addendum discusses the preparation of enantioenriched homoallylic primary amines. The most commonly used method to prepare the starting enantiomerically pure N‐tert ‐butylsulfinyl imines is the direct reaction of the corresponding carbonyl compounds with enantiomerically pure commercially available tert ‐butanesulfinamides and titanium tetraethoxide under thermal or microwave activation. The addendum also provides information on the synthetic applications of chiral N‐sulfinyl homoallylic amines.

Abstract : This document constitutes the Measuring Progress in Conflict Environments (MPICE) Metrics Framework. The Framework is a hierarchical metrics system of outcome-based goals, indicators, and measures. Once collected, the measures can be aggregated to provide indications of trends toward the achievement of stabilization goals over time. MPICE provides a system of metrics that can assist in formulating policy and implementing strategic and operational plans to transform conflict and bring stability to war-torn societies. These metrics provide the content for baseline operational -- and strategic-level -- assessments allowing policy-makers to diagnose potential obstacles to stabilization prior to an intervention. The principal purpose is to enable practitioners to track progress from the point of intervention through stabilization and, ultimately, to a self-sustaining peace. This metrics system is designed to identify potential sources of continuing violet conflict and instability and to gauge the capacity of indigeneous institutions to overcome them. The intention is to assist policy-makers in establishing realistic goals, bringing adequate resources and authorities to bear, focusing their efforts strategically, and enhancing prospects for attaining an enduring peace.