Biotechnology applications are increasingly turning to CMOS integrated biosensor arrays for massive parallelism and increased throughput in biomolecular diagnostics [1], [2]. Yet many opportunities still remain to take advantage of the spatially-resolved nature of dense semiconductor platforms to open up new imaging dimensions [3], [4], [5] which complement traditional microscopy. To better understand the emergence of spatial organization in living systems, we require techniques that dynamically probe the spatial structure of assemblies of millions of cells or more. Optical microscopy is the dominant technique, but large field-of-view microscopes have an inherent tradeoff with resolving fine features. Confocal microscopes can image cellular-scale 3D structures, but their bright illumination can impart severe phototoxicity, and observing large areas can be prohibitively slow.

This paper describes an inductively powered 27-Mbps, 0.08-mm3 CMOS transceiver with integrated RF receiver coils for simultaneous two-way, near-field data telemetry and power transmission for implantable systems. A four-coil inductive link operates at a 27-MHz carrier for power and a 700-MHz carrier for data telemetry with the antennae taking an area of only 2 mm by 2 mm. Amplitude-shift-keying (ASK) modulation is used for data downlink at 6.6 kbps and load-shift keying (LSK) backscattering is used for data uplink at 27 Mbps. The transceiver consumes 2.7 mW and can power a load consuming up to an additional 1.5 mW. Implemented in a 0.18-um silicon-on-insulator (SOI) technology, post-processing steps are used to decrease chip thickness to approximately 15um, making the chip flexible with a tissue-like form factor and removing the effects of the substrate on coil performance. Power harvesting circuitry, including passive rectifier, voltage regulator, RF limiter, ASK and LSK modulator, clock generator, and digital controller are positioned adjacent to the coils and limited to an area of 0.5 mm by 2mm. Complete transceiver functionality of the system has been achieved with overall power transfer efficiency (PTE) of 1.04% through 1 mm of tissue phantom between reader and implant.