Accurate and early detection of bone cancer is critical for improving patient outcomes, yet conventional radiographic interpretation remains limited by subjectivity and variability. Conventional AI models often struggle with complex multi-modal noise distributions, non-convex and topologically entangled latent manifolds, extreme class imbalance in rare oncological conditions, and heterogeneous data fusion constraints. To address these challenges, we present a Quantum-Inspired Classical Convolutional Neural Network (QC-CNN) inspired by quantum analogies for automated bone cancer detection in radiographic images. The proposed architecture integrates classical convolutional layers for hierarchical feature extraction with a classical variational layer motivated by high-dimensional Hilbert space analogies for enhanced pattern discrimination. A curated and annotated dataset of bone X-ray images was utilized, partitioned into training, validation, and independent test cohorts. The QC-CNN was optimized using stochastic gradient descent (SGD) with adaptive learning rate scheduling, and regularization strategies were applied to mitigate overfitting. Quantitative evaluation demonstrated superior diagnostic performance, achieving high accuracy, precision, recall, F1-score, and area under the receiver operating characteristic curve (AUC). Results highlight the ability of classical CNN with quantum-inspired design to capture non-linear correlations and subtle radiographic biomarkers that classical CNNs may overlook. This study establishes QC-CNN as a promising framework for quantum-analogy motivated medical image analysis, providing evidence of its utility in oncology and underscoring its potential for translation into clinical decision-support systems for early bone cancer diagnosis. All computations in the present study are performed using classical algorithms, with quantum-inspired concepts serving as a conceptual framework for model design and motivating future extensions.

The photonic spin Hall effect (PSHE) originates from the spin–orbit interaction (SOI) of light. The literature indicates that the transverse spin-dependent shift, δH− (SDS), from the PSHE is weak (in the nanometer range) and difficult to measure directly. This study utilizes a plasmonic structure to improve the δH− in the PSHE. The obtained results of this study demonstrate that the inclusion of silicon nitride (Si3N4) significantly enhances the δH− relative to its absence; however, plasmonic material is present in both cases. The enhanced shifts exhibit a significant dependence on the resonance angle (θr) and the thickness of layers of the PSHE structure to attain the maximum increase in δH− of 350.82 µm at the plasmonic resonance condition. A systematic analysis of the centroid positions of the reflected beam indicates a distinct and constant separation of opposing spin components. Further, the improved δH− is utilized in cancer cell detection, as changes in the refractive index (RI) of cells facilitate the identification of cancer cells from healthy to cancerous. All examined cell types demonstrate that cancerous cells had a greater δH− than normal cells, owing to their elevated effective RI. These results illustrate that the proposed plasmonic-assisted PSHE structure offers significant enhancement and a high sensitivity of 439.30 µm/RIU for label-free detection of cancer cells.

Bell–CHSH is an inequality about unconditional expectations: under measurement independence, Bell locality, and bounded outcomes, the CHSH value satisfies S≤2. Experimental correlators, however, are often computed on an accepted subset of trials defined by detection logic, coincidence matching, quality cuts, and analysis windows. We model this by an acceptance probability γ(a,b,λ)∈[0,1] and the resulting accepted hidden-variable law νab obtained by weighting the measurement-independent prior ρ by γ and renormalizing. If νab depends on the setting pair then the four correlators entering CHSH are expectations under four different measures, and a Bell-local measurement-independent model can yield Sobs>2 by selection alone. We quantify the required setting dependence in total variation (TV) distance. For any reference law μ we prove the sharp bound Sobs≤2+2∑q∈QTV(νq,μ) for a CHSH quartet Q. Optimizing over μ yields the intrinsic dispersion bound Sobs≤2+2ΔQ, and, in particular, Sobs≤min{4,2+6DQ}, where DQ is the quartet TV diameter. The constants are optimal. Consequently, reproducing Tsirelson’s value 22 within Bell-local measurement-independent models via setting-dependent acceptance requires ΔQ≥2−1 (hence, DQ≥(2−1)/3). We then propose a two-lane experimental audit protocol: (i) prior-relative fair-sampling diagnostics using tags recorded on all trials, and (ii) prior-free dispersion diagnostics using accepted-tag distributions across settings, with ΔQ,X computable by linear programming on finite tag alphabets.

Quantum anomalies are traditionally understood as classical symmetries that fail to survive quantization, while experimental “anomalies” denote deviations between theoretical predictions and measured values. In this work, we develop a unified framework in which both phenomena can be interpreted through the lens of algebraic quantum field theory (AQFT). Building on the renormalization group viewed as an extension problem, we show that renormalization ambiguities correspond to nontrivial elements of Hochschild cohomology, giving rise to a deformation of the observable algebra A∗B=AB+εω(A,B), where ω is a Hochschild 2-cocycle. We interpret ω as an intrinsic algebraic curvature of the net of local algebras, namely the (local) Hochschild class that measures the obstruction to trivializing infinitesimal scheme changes by inner redefinitions under locality and covariance constraints. The transported product is associative; its first-order expansion is associative up to O(ε2) while preserving the ∗-structure and Ward identities to the first order. We prove the existence of nontrivial cocycles in the perturbative AQFT setting, derive the conditions under which the deformed product respects positivity and locality, and establish the compatibility with current conservation. The construction provides a direct algebraic bridge to standard cohomological anomalies (chiral, trace, and gravitational) and yields correlated deformations of physical amplitudes. Fixing the small deformation parameter ε from the muon (g−2) discrepancy, we propagate the framework to predictions for the electron (g−2), charged lepton EDMs, and other low-energy observables. This approach reduces reliance on ad hoc form-factor parametrizations by organizing first-order scheme-induced deformations into correlation laws among low-energy observables. We argue that interpreting quantum anomalies as manifestations of algebraic curvature opens a pathway to a unified, testable account of renormalization ambiguities and their phenomenological consequences. We emphasize that the framework does not eliminate renormalization or quantum anomalies; rather, it repackages the finite renormalization freedom of pAQFT into cohomological data and relates it functorially to standard anomaly classes.

We revisit the premise that spacetime geometry must be quantized and show that this assumption is not physically required. Just as one does not quantize pressure or temperature, quantizing the metric treats a macroscopic continuum variable as if it were microscopic. We develop an alternative approach, Chronon Field Theory (ChFT), in which a smooth timelike covector Φμ obeys a unified variational principle—the Temporal Coherence Principle (TCP). In appropriate long-wavelength and low-vorticity regimes, the TCP dynamics yield an emergent Lorentzian metric and reproduce the Einstein field equations to leading order. Phase-coherent excitations exhibit a universal invariant speed and admit an eikonal limit that reproduces Hamilton–Jacobi and Schrödinger-type dynamics. Despite the presence of a microscopic causal alignment field, exact operational Lorentz invariance is preserved because all observers and measuring devices co-emerge from the same causal medium. The framework predicts small higher-order dispersive corrections to relativistic propagation while maintaining a universal causal cone, with effects constrained by fast radio burst and multi-messenger observations. ChFT thus provides a compact effective description in which gravitational and quantum dynamics emerge from a single coherence principle, without postulating quantum geometry at the fundamental level.

In view of the remarkable progress in microrheology to monitor the random motion of Brownian particles with a size as small as a few nanometers, and given that de Broglie matter waves have been experimentally observed for large molecules of comparable nanometer size, we examine whether Brownian particles can manifest a particle-wave duality without employing a priori arguments from quantum decoherence. First, we examine the case where Brownian particles are immersed in a memoryless viscous fluid with a time-independent diffusion coefficient, and the requirement for the Brownian particles to manifest a particle-wave duality leads to the untenable result that the diffusion coefficient has to be proportional to the inverse time, therefore, diverging at early times. This finding agrees with past conclusions published in the literature, that quantum mechanics is not equivalent to a Markovian diffusion process. Next, we examine the case where the Brownian particle is trapped in a harmonic potential well with and without dissipation. Both solutions of the Fokker–Planck equation for the case with dissipation, and of the Schrödinger equation for the case without dissipation, lead to the same physically acceptable result—that for the Brownian particle to manifest a particle-wave duality, its mean kinetic energy kBT/2 needs to be ½ the ground-state energy, E0=12ℏω of the quantum harmonic oscillator. Our one-dimensional calculations show that for this to happen, the trapping needs to be very strong so that a Brownian particle with mass m and radius R needs to be embedded in an extremely stiff solid with shear modulus, G proportional to m/RkBT/ℏ2.

The mathematical universe of the quantum topos, which is formulated on the basis of classical Boolean snapshots, delivers a neo-realist description of quantum mechanics that preserves realism. The main contribution of this article is developing formal objectivity in physical theories beyond quantum mechanics in the topos-theory approach. It will be shown that neo-realist responses to non-perturbative structures of quantum field theory do not preserve realism. In this regard, the method of Feynman graphons is applied to reframe the task of describing objectivity in quantum field theory in terms of replacing the standard Hilbert-space/operator-algebra ontology with a new context category built from a certain family of topological Hopf subalgebras of the topological Hopf algebra of renormalization as algebraic/combinatorial data tied to non-perturbative structures. This topological-Hopf-algebra ontology, which is independent of instrumentalist probabilities, enables us to reconstruct gauge field theories on the basis of the mathematical universe of the non-perturbative topos. The non-Boolean logic of the non-perturbative topos cannot be recovered by classical Boolean snapshots, which is in contrast to the quantum-topos reformulation of quantum mechanics. The article formulates a universal version of the non-perturbative topos to show that quantum field theory is a globally and locally neo-realist theory which can be reconstructed independent of the standard Hilbert-space/operator-algebra ontology. Formal objectivity of the universal non-perturbative topos offers a new route to build objective semantics for non-perturbative structures.

Due to the important role of quantum information technology in the future development of science and technology, researchers have extensively studied the preparation, characterization, and application of quantum systems. It is of great significance to further study the universality and generalization of multi-qubit entangled states. Especially in quantum communication, the actual quantum system is always affected by various noises from the environment. Noise has a significant impact on the properties of the actual quantum system, so we study the effects of noise on a prepared two-photon four-qubit state by two methods. We experimentally simulated the most common bit-flip noise in quantum systems. The law of evolution of the fidelity of two-dimensional four-qubit states and violation of the Mermin inequality and the Ardehali inequality for LR under different levels of bit-flip noise are investigated. The experimental results show that entanglement fidelity and nonlocality can be used to judge the degree of noise interference in the quantum channel and, thus, judge the security of the quantum communication channel. This judgment is of great significance for the realization of practical long-distance multi-node quantum communication.

This paper aims to address the possibility of parametric resonance effects in microtubules via tryptophan qubits, using the Hamiltonian of the cavity quantum electrodynamics (QED) model involving photons in a waveguide and the surrounding environment. The time evolution equations for qubits and photons are derived using the input–output formulation. Input signals with a 560 nm wavelength are amplified by Rabi oscillations for tryptophan qubits in excited states. Here, the qubits organized in multiple layers are all in excited states. When an appropriate decay to the environment occurs as internal loss, which is prepared in multiple layers, we find binary patterns of the parametric amplification of input signals and the reduction of output signals. This property might help us to understand the information processing of optical signals by filtering them with the use of tryptophan residues in microtubules and diffused nonlocal processing spreading over the whole brain in the form of holograms.

A brief review of various existing mathematical formulations of the uncertainty relations in quantum mechanics, containing variances of two or more non-commuting operators, is given. In particular, inequalities for the products of higher-order moments of a coordinate and a momentum are considered, as well as inequalities making the uncertainty relations more accurate when additional information about a quantum system is available (for example, the correlation coefficient or the degree of mixing of a quantum state characterized by the trace of the squared statistical operator). The special cases of two, three, and four operators are discussed in detail.