All Research Papers Published In SLAS Discovery

Research Article
24
10.1016/j.slasd.2023.04.001

Label-free high-throughput screening via acoustic ejection mass spectrometry put into practice.

Jul 01, 2023
SLAS Discovery
Martin Winter + 9 more +9

Research Article
8
10.1016/j.slasd.2023.06.001

HTS driven by fluorescence lifetime detection of FRET identifies activators and inhibitors of cardiac myosin.

Jul 01, 2023
SLAS Discovery
Jm Muretta + 18 more +18

Small molecules that bind to allosteric sites on target proteins to alter protein function are highly sought in drug discovery. High-throughput screening (HTS) assays are needed to facilitate the direct discovery of allosterically active compounds. We have developed technology for high-throughput time-resolved fluorescence lifetime detection of fluorescence resonance energy transfer (FRET), which enables the detection of allosteric modulators by monitoring changes in protein structure. We tested this approach at the industrial scale by adapting an allosteric FRET sensor of cardiac myosin to high-throughput screening (HTS), based on technology provided by Photonic Pharma and the University of Minnesota, and then used the sensor to screen 1.6 million compounds in the HTS facility at Bristol Myers Squibb. The results identified allosteric activators and inhibitors of cardiac myosin that do not compete with ATP binding, demonstrating high potential for FLT-based drug discovery.

Research Article
162
10.1016/j.slasd.2023.03.006

In Vitro three-dimensional (3D) cell culture tools for spheroid and organoid models.

Jun 01, 2023
SLAS Discovery
Sang-Yun Lee + 3 more +3

Research Article
15
10.1016/j.slasd.2023.03.002

Comparison of two supporting matrices for patient-derived cancer cells in 3D drug sensitivity and resistance testing assay (3D-DSRT).

Jun 01, 2023
SLAS Discovery
Michaela Feodoroff + 9 more +9

Research Article
7
10.1016/j.slasd.2023.04.002

Application of human iPSC-derived macrophages in a miniaturized high-content-imaging-based efferocytosis assay.

Jun 01, 2023
SLAS Discovery
Sarah Bitzer + 8 more +8

Research Article
3
10.1016/j.slasd.2023.01.007

Automated quality control tool for high-content imaging data by building 2D prediction intervals on reference biosignatures.

Apr 01, 2023
SLAS Discovery
Alemu Takele Assefa + 3 more +3

Front Matter
10.1016/j.slasd.2023.01.004

The SLAS Discovery Editor's Top 10 for 2022.

Jan 01, 2023
SLAS Discovery
Robert M Campbell

Research Article
1
10.1016/j.slasd.2022.09.005

Development and use of a high-throughput screen to identify novel modulators of the corticotropin releasing factor binding protein.

Dec 01, 2022
SLAS Discovery
Carolina L Haass-Koffler + 16 more +16

Research Article
16
10.1016/j.slasd.2022.06.003

Point-of-use, automated fabrication of a 3D human liver model supplemented with human adipose microvessels.

Sep 01, 2022
SLAS Discovery
Sarah M Moss + 7 more +7

Research Article
4
10.1016/j.slasd.2022.05.002

Differential analyte derivatization enables unbiased MALDI-TOF-based high-throughput screening: A proof-of-concept study for the discovery of catechol-o-methyltransferase inhibitors.

Jul 01, 2022
SLAS Discovery
Martin Winter + 9 more +9