The electrocatalytic conversion of plant biomass into high‐value chemicals and fuels represents a pivotal pathway toward sustainable energy and chemical production. This review systematically summarizes recent advances in the electrocatalytic valorization of key biomass components—aromatic compounds (e.g., lignin‐derived phenolics), aliphatic hydrocarbons (e.g., cellulose and hemicellulose derivatives), and terpenoids. By focusing on catalyst design, reaction mechanisms, and process optimization, we highlight how tailored electrocatalytic strategies—including oxidation and reduction pathways—enable selective transformation under mild conditions. Innovations in nanostructured catalysts (e.g., single‐atom catalysts, transition metal compounds) and reactor engineering (e.g., flow cells, membrane electrode assemblies) are discussed for their roles in enhancing efficiency, selectivity, and stability. Despite progress, challenges such as catalyst durability, product separation, and feedstock complexity impede scale‐up. Future efforts should therefore prioritize robust catalytic systems, mechanistic insights via in situ/theoretical studies, and intelligent process control. Consequently, the successful development of this field is poised to make electrocatalytic biomass conversion a cornerstone technology for achieving carbon‐neutral cycles and sustainable biorefining.

Sweat monitoring offers real‐time insights into physiological conditions such as hydration, muscle fatigue, and metabolic status. However, conventional sweat sensors often face challenges associated with unstable skin contact and insufficient sampling. In this study, a fiber‐based wearable sensing platform is proposed, which incorporates semiconducting molybdenum disulfide (MoS 2 ) and polylactic acid (PLA) composite fibers fabricated via wet spinning. By exploiting the high surface‐to‐volume ratio and n‐type semiconducting nature of the MoS 2 network, the sensor selectively detects major biomarkers including electrolytes (Na + and K + ) and metabolites (lactic acid and NH 4 + ) via distinct electrostatic screening and charge trapping mechanisms. Furthermore, the intrinsic capillary action and thermal insulation of the fibers ensured reliable sweat collection without the requirement for external power. Additionally, the composite fiber exhibits piezoresistive capabilities, enabling simultaneous pressure monitoring to track physical motion. Multifunctional sensing facilitates the early diagnosis of metabolic disorders and the precise tracking of athletic performance. The developed fiber‐based sensor provides a robust textile‐integrated solution for next‐generation personalized healthcare monitoring.

Lipid confined systems, such as organelles or lipid‐based delivery carriers, play a pivotal role in human health and disease, which makes them highly significant to biotechnology research. While modern imaging techniques can reach nanometer‐scale resolution, they provide only static snapshots and must be complemented by approaches capable of capturing dynamic structural changes in a lipid confined system. Molecular dynamics (MD) simulations can address this need by offering up to atomistic detail at femtosecond resolution and enabling access to dynamics on timescales up to milliseconds, thereby complementing the experimental data. With the rapid growth of high‐performance computing capabilities, accessible temporal and spatial scales are expanding, bringing the era of computational microscopy within reach. In this article, we highlight the key challenges that remain on the path toward this vision. We overview model construction protocols based on a modular building‐block approach, together with dynamic 3D time‐resolved data extraction, analysis, and visualization workflows. Such strategies will allow the scientific community to fully exploit high‐performance computing resources and move closer to a truly computational microscopy era. With these tools in hand, MD simulations will significantly broaden their utility for experimentalists, not only in visualization but also in high throughput computational screening and experiment design.

Cement Line In their Research Article (10.1002/sstr.202500612), Wolfgang Wagermaier, Davide Ruffoni, and co-workers investigate the cement line around osteons in bone. Using high-resolution techniques, the composition-mechanics relationship of this enigmatic interface is unraveled. This cover, inspired by pop art, illustrates the lamellar pattern in osteons, with the circular rings representing regions with different mineral properties.

2D materials, such as graphene and hexagonal boron nitride (hBN), exhibit ultra‐low bending stiffness due to their monoplanar nanostructural configuration, which limits the mechanical robustness for a range of engineering applications. We address this lacuna by introducing programmed curvature in the geometry of such 2D materials without any additional mass, wherein nano‐architected meta‐atoms are topologically placed to form the target curvature. Through rigorous molecular dynamics simulations, we demonstrate that inducing pre‐curvature in monoplanar nanostructures like graphene and hBN enhances their bending rigidity significantly, surpassing even multi‐layer planar structures. The numerical simulations further reveal an unprecedented capability of tailoring the fundamental force–displacement constitutive curve along with biased and asymmetric non‐linearity programming under inverted loading directions, exploiting the sequential appearance of local instabilities as a function of the introduced curvature. The novel approach of enhancing and tailoring mechanical characteristics of 2D materials based on curvature‐dependent control of bending rigidity advances the foundational understanding concerning the mechanics of nano‐architected 2D materials, paving the way for their applications as transverse load‐bearing components and dynamic control in sensors, actuators, flexible electronics, and other nanoelectromechanical systems.

Multifunctional Sweat Sensors Semiconducting MoS2/PLA composite fibers enable textile-integrated, multifunctional sweat sensing. The wearable platform leverages capillary-driven collection, thermal insulation, and electrostatic charge-trapping mechanisms to selectively detect key biomarkers while monitoring motion. More information can be found in the Research Article by Jin-Tae Kim, Ha Uk Chung, Jang Hwan Kim, Bong Hoon Kim, and co-workers (10.1002/sstr.202500905).

The controllable spatial arrangement of active sites in confined environments is key to designing efficient supramolecular catalysts, yet achieving such control, particularly with atomic‐level precision, remains a synthetic challenge. We introduce a ligand‐engineering strategy that enables Ångstrom‐level precision in regulating the distance between cooperative active sites in isostructural porous coordination cages, enhancing catalytic performance. Three trigonal‐prismatic cages were constructed using calixarene‐based tetra‐cobalt clusters and V‐shaped dicarboxylate ligands functionalized with –NH 2 groups. Single‐crystal X‐ray diffraction shows these cages share identical topological features, with the distance between Brønsted acidic μ 4 –H 2 O sites and basic –NH 2 sites adjustable from 12.4 Å ( PCC‐16 ) to 5.6 Å ( PCC‐17 ). In the Knoevenagel condensation, PCC‐17 shows superior activity, achieving up to 96% yield, outperforming PCC‐16 and nonfunctionalized PCC‐15 . This highlights the impact of reducing intersite distance on substrate activation and intermediate coupling. Fluorescence titration, control experiments, and theoretical calculations confirm a synergistic “acid–base” dual‐activation mechanism. Computational studies support that shortened distances enhance intermediate stabilization. The system also has a broad substrate scope and excellent stability. This work demonstrates the potential of ligand‐directed and controllable spatial organization for advancing cage‐based catalytic materials, highlighting the dramatic impact of intersite distance on cooperative catalysis.

DNA Origami In their Research Article (10.1002/sstr.202500384), Petr Cigler, Vladimíra Petráková, and co-workers present a scalable method to covalently functionalize fluorescent nanodiamonds with DNA, enabling their high-yield, spatially controlled assembly with gold nanoparticles on DNA origami. They probe how interparticle spacing modulates NV center photoluminescence, revealing distance-dependent plasmonic coupling emission enhancement, and lifetime shortening.

Multidrug resistance in breast cancer is asignificant clinical challenge that often leads to treatment failure and tumor recurrence. Light‐activated therapies such as photothermal and photodynamic therapies offer spatially and temporally controlled treatments with minimal invasiveness. However, their effectiveness is limited by the instability of conventional agents, hostile tumor microenvironment, and shallow tissue light penetration. The combination of these light‐based approaches with nanotechnology has enabled the development of multifunctional nanoplatforms capable of overcoming multidrug resistance. Through rational design and surface modification, these platforms can improve drug targeting, biocompatibility, and therapeutic outcomes. Smart nanosystems for the codelivery of light‐responsive agents and drugs promote enhanced tumor accumulation, controlled drug release, and integrated diagnostics and therapies. This review examines resistance mechanisms in breast cancer and discusses light‐based strategies, emphasizing the design of advanced photoactivated nanoplatforms, their material properties, and synergistic antitumor effects. These multifunctional nanosystems demonstrate considerable potential for overcoming biological barriers and enabling precise drug release and real‐time monitoring, indicating their strong prospects for clinical applications. Future challenges and directions for clinical translation have also been addressed.

The rising incidence of cancer among young women, coupled with improved survival rates, has significantly increased the demand for effective fertility preservation strategies. It is reported that women diagnosed and treated for cancer have ≈38% lower chances of pregnancy compared to the general population. Current oncology treatments, including surgery, radiotherapy, and chemotherapy, often result in irreversible damage to the ovaries, uterus, and fallopian tubes, highlighting a critical need for innovative approaches to functional restoration. Aggregation‐induced emission (AIE) offers a promising solution to these challenges. AIE possesses unique properties such as high brightness (e.g., AIE achieves tumor‐to‐background ratios up to 15.2), superior photostability, and the ability to generate reactive oxygen species or heat upon light irradiation. This review systematically recent advancements in AIE technology for fertility preservation in female cancer patients. We focus on its applications in early tumor diagnosis and screening, precise surgical navigation, innovative treatment strategies, and the functional assessment and monitoring of reproductive organs. By integrating diagnostics and therapy, we propose that this AIE‐based approach will provide novel strategies for clinical fertility preservation, ultimately shifting the paradigm from mere survival to fertility restoration, thereby significantly enhancing patients’ quality of life.