All Research Papers Published In Trends in pharmacological sciences

Research Article
10.1016/j.tips.2026.04.009

Mechanistic insights into nitazenes at the μ-opioid receptor.

May 14, 2026
Trends in pharmacological sciences
Lijie Xia + 2 more +2

Research Article
10.1016/j.tips.2026.01.005

Dynamics and heterogeneity of the neurovascular unit in ischemic stroke.

Apr 01, 2026
Trends in pharmacological sciences
Peng Teng + 8 more +8

The neurovascular unit (NVU) is a multicellular system functioning to maintain healthy brain homeostasis and regulate the exchange of essential elements between the blood and the brain. Recent studies have shown that, in response to ischemic stroke (IS), the NVU undergoes dynamic structural remodeling and metabolic dysfunction, revealing new features of IS pathogenesis. Recent breakthroughs in single-cell multiomics provide emerging evidence regarding the spatiotemporal heterogeneity of NVU responses to IS. To date, clinical treatments for IS-induced brain injury remain very limited. These new studies have advanced our knowledge of the dynamic cellular and molecular changes of the NVU after IS, paving the way for new therapeutic strategies.

Research Article
2
10.1016/j.tips.2025.08.004

Targeting Tregs in T1DM: bridging heterogeneity, mechanisms, and clinical progress.

Apr 01, 2026
Trends in pharmacological sciences
Yutong Li + 1 more +1

Research Article
1
10.1016/j.tips.2026.01.006

Leveraging conformational ensembles in allosteric drug discovery.

Mar 01, 2026
Trends in pharmacological sciences
Ruth Nussinov + 2 more +2

Research Article
2
10.1016/j.tips.2025.07.014

Beyond lipids: fenofibrate in diabetic retinopathy and nephropathy.

Mar 01, 2026
Trends in pharmacological sciences
Mengying Liu + 4 more +4

Research Article
10.1016/j.tips.2026.01.010

Pharmacological strategies targeting hepatocyte-mediated crosstalk in liver fibrosis.

Mar 01, 2026
Trends in pharmacological sciences
Yue Zhang + 4 more +4

Research Article
3
10.1016/j.tips.2025.09.005

WEE-family kinases in cancer: synthetic lethal interactions and drug discovery.

Feb 01, 2026
Trends in pharmacological sciences
Chaofan Wang + 1 more +1

Research Article
10.1016/j.tips.2025.11.009

PDE4 modulates muscle signaling in cancer cachexia.

Feb 01, 2026
Trends in pharmacological sciences
Renming Fan + 2 more +2

Research Article
1
10.1016/j.tips.2025.10.016

Sirtuins in Alzheimer's disease: mechanistic insights and therapeutic opportunities.

Jan 01, 2026
Trends in pharmacological sciences
Ning Bai + 10 more +10

Research Article
10.1016/j.tips.2025.10.009

Sunvozertinib (Zegfrovy): an oral EGFR inhibitor that irreversibly targets exon20ins in NSCLC.

Dec 01, 2025
Trends in pharmacological sciences
Xiaoshuang Niu + 2 more +2