All Research Papers Published In Tuberculosis

Research Article
6
10.1016/j.tube.2021.102063

Genotypic diversity of Mycobacterium tuberculosis isolates and its association with drug-resistance status in Xinjiang, China

Mar 04, 2021
Tuberculosis
Wei Deng + 7 more +7

Research Article
9
10.1016/j.tube.2020.102048

Evaluation of CSF pyrosequencing to diagnose tuberculous meningitis: A retrospective diagnostic accuracy study

Jan 01, 2021
Tuberculosis
Kanchan Ajbani + 7 more +7

Research Article
31
10.1016/j.tube.2020.102038

Cough-independent production of viable Mycobacterium tuberculosis in bioaerosol

Dec 08, 2020
Tuberculosis
Benjamin Patterson + 10 more +10

BackgroundSymptoms of infectious respiratory illnesses are often assumed to drive transmission. However, production and release of Mycobacterium tuberculosis (Mtb) bioaerosols is poorly understood. We report quantitation of Mtb exhaled during specific respiratory manoeuvres. MethodsDirect capture of nascent bioaerosol particles and indirect collection of aged particles was performed in 10 healthy subjects. Indirect and direct capture of exhaled viable Mtb bacilli was compared in 38 PTB patients and directly captured viable Mtb during cough and bronchiole-burst manoeuvres in 27 of the PTB patients. ResultsDirect sampling of healthy subjects captured larger bioaerosol volumes with higher proportions of 2–5 μm particles than indirect sampling. Indirect sampling identified viable Mtb in 92.1% (35 of 38) of PTB patients during 60-min relaxed breathing, median bacillary count 7.5 (IQR: 3.25–19). Direct sampling for 10-min identified Mtb in 97.4% (37 of 38) of PTB patients with higher bacilli counts (p < 0.001), median 24.5 (IQR:11.25–37.5). A short 5-min sampling regimen of 10 coughs or 10 bronchiole-burst manoeuvres yielded a median of 11 (IQR: 4–17) and 11 (IQR: 7–17.5) Mtb bacilli, respectively (p = 0.53). ConclusionsPeripheral lung bioaerosol released through deep exhalations alone contained viable Mtb suggesting non-cough transmission is possible in PTB.

Front Matter
10.1016/j.tube.2020.102035

Further evidence that cigarette smoke and nicotine compromise host immunity against tuberculosis (invited editorial)

Dec 02, 2020
Tuberculosis
Edward D Chan + 1 more +1

Research Article
8
10.1016/j.tube.2020.102011

Population structure of multidrug-resistant Mycobacterium tuberculosis clinical isolates in Colombia

Oct 17, 2020
Tuberculosis
Juan Germán Rodríguez-Castillo + 6 more +6

Research Article
27
10.1016/j.tube.2020.102002

Laboratory development of a simple stool sample processing method diagnosis of pediatric tuberculosis using Xpert Ultra

Oct 03, 2020
Tuberculosis
Manon Lounnas + 7 more +7

Research Article
1
10.1016/j.tube.2020.102003

Identification of a Mycobacterium tuberculosis-specific gene marker for diagnosis of tuberculosis using semi-nested melt-MAMA qPCR (lprM-MAMA)

Sep 28, 2020
Tuberculosis
Kai Ling Chin + 6 more +6

Conference Article
4
10.1183/13993003.congress-2020.472

Tuberculosis in children exposed to MTB with different drug resistance patterns

Sep 07, 2020
Tuberculosis
Marina Lozovskaya + 5 more +5

Conference Article
1
10.1183/13993003.congress-2020.514

Alternate diagnosis in clinically diagnosed pulmonary tuberculosis patients treated at tertiary care hospital in a high TB burden country

Sep 07, 2020
Tuberculosis
Muhammad Irfan + 5 more +5

Conference Article
10.1183/13993003.congress-2020.5302

IP-10 decreases during antituberculous treatment in children with active tuberculosis

Sep 07, 2020
Tuberculosis
Agnieszka Strzelak + 5 more +5