The effects of the “youth protein” GDF11 and “aging proteins” ccL11, GDF15, JAM-A on cardiohemodynamics in women with essential hypertension
Objective. To identify the effects of youth and aging proteins — GDF11, CCL11, GDF15, JAM-A on cardiohemodynamics in healthy and hypertensive women. Design and methods. The study involved 102 women. The control group consisted of 30 healthy women. Hypertensives were divided into 2 groups. The first (HTN-1) included 37 women with stage II hypertension (HTN) who received antihypertensive therapy. The second group (HTN-2) included patients who received antihypertensive drugs and regularly underwent kinesitherapy for 2-3 years. The enzyme immunoassay (ELISA) method was performed to determine the levels of GDF11, GDF15, JAM-A and CCL11 proteins. All subjects underwent echocardiography and dynamic light scattering (DLS). Results. In healthy women, we found a positive correlation between the GDF15 proteins and JAM-A and blood pressure (BP). The GDF11/GDF15 ratio negatively correlated with BP level. In HTN-1 group, a negative relationship was found between the GDF15 level and the mean and pulse systolic pressure. In HTN-2 group, a negative relationship was found between CCL11 protein and pulse pressure, as well as the GDF15/CCL11 ratio and diastolic and positive correlation with the pulse pressure. In healthy subjects, no significant correlations were found between the studied proteins and cardiovascular functions, but GDF11/CCL11 ratio positively correlated with echocardiographic indices: the final systolic and impact volumes. In HTN-2 group, a positive relationship was found between the GDF11/GDF15 ratio and the minute volume, as well as GDF15/CCL11 and systolic shortening. The absolute values of hemodynamic indices (HI) in HTN-1 group were lower than in the control group, indicating a violation of the microcirculation with the trend towards the higher velocities. In HTN-2 group, hemodynamic parameters were close to those in the control group. In healthy individuals, HTN-1 and HTN-2 groups, dozens correlations were found between the studied proteins, their ratios, and various hemodynamic and oscillatory indices. Conclusions. The levels of the “youth protein” GDF11 and the “aging proteins” GDF15, CCL11, JAM-A, as well as their ratios, exhibit positive and negative relationships with BP and cardiohemodynamic functions. At the same time, the effect of GDF11 and its predominance over CCL11, GDF15 and JAM-A is mostly adaptive.
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