- Research Article
- 10.1016/j.tice.2026.103444
Proanthocyanidin alleviates vancomycin-induced kidney injury via modulation of Nrf2/Keap1/HO1, Bax/Bcl-2/Caspase-3, and TLR4/MyD88/NF-κB pathways.
- Aug 01, 2026
- Tissue & cell
- Gokhan Akcakavak + 9 more +9
Publications from 2021 to 2026
Showing 10 of 1,057 papers
Proanthocyanidin alleviates vancomycin-induced kidney injury via modulation of Nrf2/Keap1/HO1, Bax/Bcl-2/Caspase-3, and TLR4/MyD88/NF-κB pathways.
PATHOS-Lactate score: A novel prognostic tool for predicting in-hospital mortality in acute pulmonary embolism.
Palladium nanoparticles supported on amine-functionalized NiAl layered double hydroxides and investigation of their catalytic role against formic acid dehydrogenation
Altın Bankacılığında Bölgesel Performans Farklılıkları: Türkiye’de Yerli Özel Bankalar Üzerine VIKOR Tabanlı Bir Analiz
Bu çalışma, 2019-2024 döneminde Türkiye’nin 26 ilinde, NUTS-2 sınıflamasına karşılık gelen TR10, TR22, TR31, TR41, TR42, TR51, TR52, TR61, TR62 ve TR63 bölgeleri kapsamında faaliyet gösteren yerli özel bankaların altın piyasası performansını, altın kredileri ve altın mevduatı verileri temelinde analiz etmeyi amaçlamaktadır. Çalışmada, değerlendirme kriterlerinin ağırlıklandırılmasında Eşit Ağırlıklandırma yöntemi uygulanmıştır. Yerli özel bankaların altın piyasasındaki performanslarının karşılaştırılması amacıyla Çok Kriterli Karar Verme (ÇKKV) yöntemlerinden VIKOR tercih edilmiştir. VIKOR yönteminin seçilme nedeni, birden çok ve birbirini etkileyen kriteri eş zamanlı olarak değerlendirebilmesi ve alternatifler arasında uzlaşmacı, ideal çözüme yakın bir sıralama sunabilmesidir. Elde edilen bulgular, özel bankaların altın performansının yıllar içinde iller arasında farklılık gösterdiğini ortaya koymaktadır. 2019 yılında altın performansı açısından en iyi performans gösteren iller İzmir, Adana ve Kocaeli iken, en düşük performansı gösteren iller Konya, Isparta ve Karaman olmuştur. 2024 yılına gelindiğinde ise, altın performansı en yüksek iller İzmir, Ankara ve Mersin olarak belirlenirken, Bilecik, Burdur ve Karaman illerinin en düşük performans grubunda yer aldığı tespit edilmiştir. Elde edilen bulgular, yerli özel bankaların altın piyasası faaliyetlerinin bölgesel ekonomik yapı, finansal derinlik ve bankacılık altyapısı ile yakından ilişkili olduğunu göstermektedir.
Read moreBÜYÜKŞEHİRLERDE GEÇİCİ KORUMA KAPSAMINDA BULUNAN SURİYELİLERİN YEREL YÖNETİM POLİTİKALARINA ETKİSİ
Türkiye, özellikle 2011 yılında Suriye’de başlayan iç savaşın ardından yaşanan yoğun göç dalgası ile bu olgunun etkilerini derinlemesine yaşamaktadır. Türkiye’nin coğrafi konumu ve Suriye’ye olan sınır komşuluğu, Suriyeli göçmenlerin önemli bir kısmının Türkiye’ye sığınmasına neden olmuş; bu durum, başta yerel yönetimler olmak üzere birçok kamu kurumunun politika üretme süreçlerinde köklü değişikliklere yol açmıştır. Bu bağlamda çalışmanın amacı, geçici koruma statüsünde bulunan Suriyeli göçmenlerin Türkiye’deki belediyelerin göç politikaları üzerindeki etkilerini ortaya koymak, bu politikaların yeterlilik düzeylerini değerlendirmek ve karşılaşılan sorunlara yönelik geliştirilen çözüm önerilerini analiz etmektir. Araştırmada, Göç İdaresi Başkanlığının 2025 yılı verileri doğrultusunda geçici koruma kapsamındaki Suriyelilerin en yoğun yaşadığı on büyükşehir belediyesi (İstanbul, Gaziantep, Şanlıurfa, Adana, Hatay, Mersin, Bursa, Konya, İzmir ve Ankara) örneklem olarak seçilmiştir. Doküman analizi yöntemi kullanılarak bu belediyelerin 2015 sonrası faaliyet raporları, stratejik planları ve yerel göç projeleri incelenmiş; göçmenlere yönelik geliştirilen politika ve uygulamalar karşılaştırmalı olarak analiz edilmiştir. Yapılan analizler sonucunda, her bir büyükşehir belediyesinin göç politikalarının; bulundukları bölgenin demografik yapısı, ekonomik kapasitesi ve göçmen yoğunluğuna bağlı olarak farklılık gösterdiği, bununla birlikte göç olgusunu öncelikli bir mesele olarak ele alan belediyelerin daha aktif ve kapsamlı çalışmalar yürüttüğü tespit edilmiştir.
Read moreA Bibliometric Analysis and Visualization of Literature on the Relationship Between Sustainable Food and Climate Change Over the Last Quarter Century
ABSTRACT As a result of the increase in the world's population, natural resources have faced the danger of depletion and therefore issues such as environmental degradation and climate change have started to be addressed within the framework of “sustainability”. The aim of this study is to use bibliometrics and content analysis to visualize hotspots and emerging trends in studies examining the relationship between sustainable food and climate change. An initial search of the Web of Science Core Collection yielded 1166 records. After applying filters for document type (articles, reviews, and proceedings), publication year (2000–2025), and language (English), a final dataset of 1080 publications was obtained. Bibliometric analyzes were performed using the Biblioshiny package and VOSviewer to examine author productivity, country‐level contributions, thematic clusters, and citation networks. VOSviewer was employed for the visualization and mapping of bibliometric networks, while Biblioshiny was used to generate descriptive statistics. In addition, content analysis of the 20 most‐cited articles was conducted to synthesize their objectives, key findings, and recommendations for future research. Publication output increased sharply after 2015, indicating a growing academic interest in climate change and sustainable food. The volume of global production, led by countries such as the United States, China and the United Kingdom, and key terms in keyword clusters such as “food security”, “climate change” and “sustainable agriculture” collectively indicate that this field has become both a political and scientific priority. The most cited papers emphasized the need for interdisciplinary approaches that integrate technology (e.g., artificial intelligence, nanotechnology), land management and sustainable dietary changes. In conclusion, this study shows how sustainable food systems and climate‐related academic efforts are evolving globally. Future research should consider the multitude of variables that influence this link and develop research accordingly.
Read moreEffects of Yoga-Based Interventions on Quality of Life and Psychosocial Variables in Caregivers: Systematic Review and Meta-Analysis.
This meta-analysis investigated the effects of yoga-based interventions on caregiver quality of life and psychosocial variables. This study was conducted as a systematic review and meta-analysis. A comprehensive literature search was conducted through September 2024 across Web of Science, CENTRAL, PubMed, and MEDLINE, identifying 926 records. After duplicate removal, 658 studies were screened by title and abstract, and 35 articles underwent full-text assessment. After exclusions due to reporting issues, insufficient data, or irrelevant outcomes, 12 studies were ultimately included in the meta-analysis. This meta-analysis demonstrated that yoga-based interventions were associated with a significant reduction in caregivers' anxiety [standardised mean difference (SMD)=-0.99, p=.003], depression (SMD=-0.69, p=.002), and stress levels (SMD=-0.35, p=.028). In addition, yoga-based interventions led to a significant improvement in psychological quality of life (SMD=0.82, p<.001) and overall quality of life (SMD=0.88, p=.007). In contrast, yoga-based interventions did not show a statistically significant effect on caregiver burden, physical quality of life, social relationships, or financial status (p>.05). Nurses may recommend yoga-based interventions to caregivers as a way to support their mental health, psychosocial well-being, and quality of life. Yoga-based interventions were effective in improving the quality of life and psychosocial variables among caregivers.
Read morePauli Gaussian Leonardo quaternions
In this paper, a new family of Pauli quaternions whose components are the Gaussian Leonardo numbers is defined. These new Pauli quaternions are called Pauli Gaussian Leonardo quaternions. Furthermore, several properties of Pauli Gaussian Leonardo quaternions, including relations with the Pauli Gaussian Fibonacci and Pauli Gaussian Lucas quaternions are investigated. In addition, Binet-like formula, (ordinary) generating function, exponential generating function, and some summation formulas for these Pauli quaternions are given. Moreover, some results are illustrated with examples.
Read moreProtective Effect of Olive Leaf Extract on Renal Ischemia/Reperfusion Injury in Rats
Aim: Renal ischaemia/reperfusion (I/R) injury, which is an important contributing factor to acute kidney damage, leading to increased morbidity and mortality. Olive leaf extract (OLE) possesses antioxidant and anti-inflammatory properties due to its rich polyphenolic content. This study comprehensively investigates the protective effects of OLE obtained from the Memecik variety of olive leaves against renal I/R injury, evaluated by employing two different doses.Material and Methods: A total of 32 male Wistar albino rats were randomly divided into four groups: Sham, Control I/R, I/R+OLE200, and I/R+OLE400. Serum biochemical parameters (urea, creatinine, electrolytes, total antioxidant status [TAS], total oxidant status [TOS], TNF-α, IL-1β, IL-6, and nitric oxide [NO]) and renal tissue histopathology were evaluated.Results: OLE significantly improved serum biochemical parameters, reduced pro-inflammatory cytokines, and enhanced systemic antioxidant capacity, indicated by increased TAS and decreased TOS levels compared to the I/R control group (p
Read moreExperimental and Numerical Investigation of the Effect of Insufficient Edge Distance on the Behavior of Cold-Formed Steel Screw Connections
This study investigates the shear behavior of cold-formed steel single-lap screw connections both experimentally and numerically, with a particular focus on the critical influence of edge distance. A total of 20 specimens were tested to evaluate the effects of sheet thickness, screw diameter, number of screws, screw arrangement, and edge distance on connection load-carrying capacity and failure modes. The experimental results showed that increasing the sheet thickness nearly doubled the connection capacity, while the effect of screw diameter was found to be limited. Conversely, a reduction in horizontal edge distance had a critically adverse effect on the connection performance. In addition, detailed finite element models were developed in ABAQUS and validated against the experimental data. The numerical models accurately predicted the load-displacement behavior, load-carrying capacities, and failure modes, demonstrating that they serve as a reliable tool for future parametric studies.
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