Antares Pharma (United States)

The article analyzes the directions of formation and implementation of blue economy projects in Tanzania (including Madagascar), which has access to the sea. The purpose of the article is to explore the possibilities and limitations of the blue economy using the example of the United Republic of Tanzania as one of the African countries. The article shows that the global economy is coming to the fore in Tanzania. The state pays great attention to projects in this area, but it has not yet been possible to activate private investment in the sector. Despite the fact that the country has significant blue resources and the potential for their development, they already provide significant employment, albeit with low segment efficiency. Taking into account population growth and the need for sustainable development, it is the blue sectors of the national economy that can become the driver of its stable and long-term growth in the future. At the same time, financing problems are one of the main intractable issues hindering blue projects. Among other problems, as the author notes, there is an insufficient level of blue management, i.e. management of blue resources. Thus, it can be concluded that Tanzania is not yet included in the group of African states – leaders of the blue economy.

BackgroundCD8+ T regulatory (Treg) cells that recognize the nonclassical class 1b molecule Qa-1/human leukocyte antigen E (Q/E CD8+ Treg cells) are important in maintaining self-tolerance. We sought to investigate the role that these T cells play in type 1 diabetes (T1D) pathogenesis and whether an intervention targeting this mechanism may delay T1D progression.MethodsWe conducted a phase 1/2, randomized, double-blind, placebo-controlled trial of the autologous dendritic cell therapy AVT001 that included participants at least 16 years of age, within 1 year of T1D diagnosis, and with ex vivo evidence of a defect in Q/E CD8+ Treg function. Patients were randomly assigned in a 2:1 ratio to AVT001 or placebo, which was administered in three monthly intravenous infusions. The primary end point was safety; efficacy end points included changes from baseline in C-peptide area under the curve (AUC) during a 4-hour mixed meal, hemoglobin A1c (HbA1c), and insulin dose.ResultsSixteen patients received AVT001, and nine received placebo. Similar rates and severity of adverse events were observed in both groups. None of the patients in the AVT001 group had serious adverse events through visit day 360. Compared with placebo, treatment with ATV001 was associated with less decline from baseline log-transformed C-peptide AUC (nmol/l), with the treatment effect between AVT001 and placebo at day 150 of 0.09 (95% confidence interval [CI], 0.03 to 0.15) and at day 360 of 0.10 (95% CI, 0.04 to 0.15). No clear differences in change in HbA1c and insulin dose from baseline were observed between groups. Estimated treatment effects of AVT001 versus placebo at day 360 were −0.17% (95% CI, −0.60 to 0.26%) for HbA1c and −0.06 U/kg/day (95% CI, −0.14 to 0.02) for daily insulin dose.ConclusionsIn this phase 1/2 trial, AVT001 did not result in dose-limiting adverse events. Potential signals of efficacy observed here warrant further evaluation in a fully powered trial. (Funded by Avotres Inc. and the Division of Diabetes, Endocrinology, and Metabolic Diseases; ClinicalTrials.gov number, NCT03895996.)

Introdução: Infecções hospitalares são as que acontecem em pacientes internados, ou em pacientes após alta e que exibiram sinais de infecção de 48 a 72 horas após a mesma. A nomenclatura infecção hospitalar está sendo modificado pela nomenclatura infecção relacionada à assistência à saúde. Isso se dá pelo motivo de exclui as infecções hospitalares somente com a infecção adquirida no hospital, podendo também associar a infecções ligadas a outros meios de assistência à saúde, como ambulatórios e clínicas (STUBE et al., 2013). As unidades hospitalares são avaliadas como amplo reservatório de microrganismos oportunistas, a exemplo de bactérias, fungos e vírus. Desta maneira, o perfil das infecções que acontecem na atmosfera nosocomial se mostra diferenciado das contraídas na comunidade, sobretudo no que diz a respeito quanto à frequência, sítio de infecção e tipo de microrganismo isolado Grillo et al., 2013. A resistência microbiana é um grave problema de saúde pública no mundo, pela elevada mortalidade e pelo reduzido número de opções terapêuticas. O ambiente hospitalar é hostil e propício ao desenvolvimento de infecções Brasil, 2017. O exame de hemocultura versa a fundamental metodologia de detecção de microorganismos em corrente sanguínea. Nesse sentido os microrganismos interatuam com o hospedeiro e levam a uma resposta local e/ou sistêmica, diferenciando assim uma infecção, quando existe uma desregulação e uma exacerbação desta resposta com propensão ao risco de vida, surge assim, a sepse (SINGER, 2016). Os setores de terapia intensiva são ambientes fáceis para o aparecimento da resistência antimicrobiana, isso se dá e pode ser notado por múltiplos fatores, agrupamento de pacientes graves, como uso frequente de antimicrobianos de amplo espectro, internações e espaço físico restrito, desenvolvendo a possibilidade de transmissão de microrganismos de pessoa a pessoa Kollef, Micek, 2005. Objetivos: Avaliar a incidência de bactérias e fungos e o perfil de sensibilidade e resistência apresentados por elas. Método: Trata-se de um estudo retrospectivo, transversal, não controlado, realizado no ano de 2017, no Hospital Universitário Professor Alberto Antunes (HUPAA/UFAL), Maceió/AL. Para testes de susceptibilidade dos microorganismos aos antimicrobianos, as amostras foram identificadas e processadas seguindo o protocolo CLSI (Manual Clinical and Laboratory Standards Institute) e nota técnica da ANVISA nº01/2013. Resultados: As bactérias Gram-Positivas mais incidentes isoladas em hemoculturas, coletados durante o ano de 2017 foram: Staphylococcus epidermidis (30,76%), Staphylococcus haemolyticus (30,76%) Staphylococcus aureus (12,91%), Staphylococcus lugdunensis (12,91%) e Staphylococcus saprophyticus (12,91%). As bactérias Gram-Negativas mais incidentes do ano de 2017 de janeiro a dezembro foram Klebisiela pneumoniae (42,85%) e Pseudomonas aeruginosa (28,57%), Acinetobacter balmannii em (14,28%) e Enterobacter cloacae (14,28%). Quanto ao perfil, as bactérias Gram-Positivas demonstraram um maior perfil de resistência a Penicilina (77,77%), Eritromicina (67,79%) e Clindamicina (57,05%). Quanto as sensibilidades, as melhores respostas foram para Tigeciclina (95,68%), Vancomicina (90,86%) e Teicoplanina (92,32%). Os antimicrobioanos que apresentaram maior porcentagem de resistência às amostras de material clínico das bactérias Gram-Negativas foram Ampicilina (91,37%), Ampicilina/Subactam (75,85%) e Sulfametoxazol + Trimetoprima (73,36%). As maiores sensibilidades apresentadas foram ao Ertapenem (87,49%), Amicacina (87,36%), Colistina (83,69%), Imipenem e Meropenem (72,06%). Discussão: As taxas de infecção hospitalar dentro das unidades de terapia intensiva variam entre 18 e 54%, sendo cerca de cinco a dez vezes maiores do que em outras unidades de internação de um hospital. Confirmando-se todos os isolados das bactérias Gram-negativas com outros estudos da literatura observa-se a Klebsiela pneumoniae como bactéria predominante nas amostras de sangue. Assim como nas bactérias Gram- positivas observa-se a predominância dos Staphylococcus coagulase negativo. Estudos em vários locais são necessários para avaliar o perfil epidemiológico, perfil microbiológico e o desfecho atual das infecções relacionadas a assistência à saúde em UTIs brasileiras. Considerações finais: Percebe-se que as elevadas taxas de mortalidade estão associadas às infecções de corrente sanguínea (Machado et al., 2017). De tal modo, estudos nessa perspectiva permitem que ocorra um trabalho conjunto com o serviço de controle de infecção hospitalar para direcionamento apropriado do serviço de saúde na elaboração de protocolos sobre uso racional de antibióticos, como também a implementação de medidas precaução e controle das infecções, com o intuito de minimizar taxas de morbimortalidade, os custos em saúde e o tempo de internação.

ANTARES is the largest undersea neutrino telescope and it has been taking data in its final configuration for more than ten years. On their journey to the Earth, cosmic rays can be absorbed by celestial objects, like the Sun, leading to a deficit in the atmospheric muon flux measured by the ANTARES detector, the so-called Sun "shadow" effect. This phenomenon can be used to evaluate fundamental telescope characteristics: the detector angular resolution and pointing accuracy. This work describes the study of the Sun "shadow" effect using the ANTARES data collected between 2008 and 2017. The statistical significance of the Sun shadow observation is $3.7\sigma$ and the estimated angular resolution value of the ANTARES telescope for downward-going muons is $0.59^{\circ} \pm 0.10^{\circ}$, which is consistent with the expectations obtained from the Monte Carlo simulations and also with the estimation from the Moon "shadow" analysis of 2007-2016 years. No evidence of systematic pointing shift is found and the resulting pointing accuracy is consistent with the expectations.

Abstract Hydrologic modeling was used to estimate potential changes in nutrients, suspended sediment, and streamflow in various biomass production scenarios with conservation practices under different landscape designs. Two major corn and soybean croplands were selected for study: the South Fork of the Iowa River watershed and the headwater of the Raccoon River watershed. A physically based model, the Soil and Water Assessment Tool, was used to simulate hydrology and water quality under different scenarios with conservation practices and biomass production. Scenarios are based on conservation practices and biomass production; riparian buffer (RB), saturated buffer, and grassed waterways; various stover harvest rates of 30%, 45%, and 70% with and without winter cover crops; and conversion of marginal land to switchgrass. Conservation practices and landscape design with different biomass feedstocks were shown to significantly improve water quality while supporting sustainable biomass production. Model results for nitrogen, phosphorus, and suspended sediments were analyzed temporally at spatial scales that varied from hydrologic response units to the entire watershed. With conservation practices, water quality could potentially improve by reducing nitrogen loads by up to 20%–30% (stover harvest with cover crop), phosphorus loads by 20%–40% (RB), and sediment loads by 30%–70% (stover harvest with cover crop and RB).

This paper presents a design for a feedstock logistics system to supply a bioenergy plant located in the Southeast USA, specifically Piedmont, a physiographic region covering part of five states (VA, NC, SC, GA, and AL). The design uses a perennial grass (switchgrass) as the feedstock. Harvest is done with a round baler, and round bales are stored in single-layer ambient storage in satellite storage locations. New technology, 20-bale racks, was designed as the multi-bale handling unit. The analysis shows how proper design of the interactions between the several unit operations in a “logistics chain” can be used to minimize average delivered cost for the feedstock required for 24/7 operation. Racks are loaded at the satellite storage and delivered by hauling contractors hired by the plant and controlled by a “Feedstock Manager” at the plant to insure approximately the same number of loads are received each day. Single-bale handling at the plant is eliminated, thus the truck unload time is reduced and truck productivity (tons/day) is increased. At-plant handling and storage in 20-bale racks increases plant receiving facility productivity, and gives a reduction in plant cost to supply a continuous steam of material for 24/7 operation.

The Advanced LIGO observatories detected gravitational waves from two binary black hole mergers during their first observation run (O1). We present a high-energy neutrino follow-up search for the second gravitational wave event, GW151226, as well as for gravitational wave candidate LVT151012. We find two and four neutrino candidates detected by IceCube, and one and zero detected by Antares, within ±500 s around the respective gravitational wave signals, consistent with the expected background rate. None of these neutrino candidates are found to be directionally coincident with GW151226 or LVT151012. We use nondetection to constrain isotropic-equivalent high-energy neutrino emission from GW151226, adopting the GW event's 3D localization, to less than 2×1051-2×1054 erg. © 2017 American Physical Society.

This study analyzes the reaction of the U.S. Treasury bond market to innovations in macroeconomic fundamentals. We identify these innovations with macroeconomic news, defined as differences between the actual releases and their market expectations. We show that macroeconomic news explain about one-third of the low frequency (quarterly) fluctuations of long-term bond yields. When focusing on the high frequency (daily) movements this share decreases to one-tenth. This result is due to the fact that macro news have a persistent effect on the yield curve. Non-fundamental factors, instead, substantially influence the day-to-day movements of bond yields but their effects are shorter-living and mean-reverting.

The ANTARES telescope, with a duty cycle close to unity and a full hemisphere of the sky at all the times visible, is well suited to detect neutrinos produced in astrophysical transient sources. Assuming a known neutrino production period, the background and the sensitivity can be drastically improved by selecting a narrow time window around it. GRBs, {\mu}-quasars and AGNs are particularly attractive potential neutrino point sources since neutrinos and gamma-rays may be produced in hadronic interactions with the surrounding medium as they are the most likely sources of the observed ultra high energy cosmic rays. A strong correlation between the gamma-ray and the neutrino fluxes is expected in this scenario. ANTARES data has been analysed in various transient source analyses with the goal of detecting cosmic neutrinos from GRBs, {\mu}-quasars and AGNs. The sensitivity of a standard time-integrated point source search can be improved by a factor 2-3 by looking for neutrinos only during the most probable emission time. This information can be provided by the different satellite telescope types on the X-rays and gamma-rays wavelengths. The results of these different analyses will be presented.