Assam University

Abstract The study intends to investigate the tourism industry by adopting the constructed environment (CE) concept. It has been on the visual radar of developing tourism industries by increasing investment, infrastructure development, services, and facilities to bolster industrial development. It is evident that there is always room for improvement and changes in methods that were applied earlier due to industry dynamism and tourist psychological trends. One of the key aspects of CE is the participation of various stakeholders’ consciousness toward policymaking, perceptions toward the tourist psychology, and competence of the constructor and worker associations for the sustainable growth of the industries. The study has two objectives. First, the authors propose that the study explain the sustainability principle while defining CE and every aspect the tourists expect from the industries and visited destinations. To comprehend tourist psychology, the study proposes to use the Maslow hierarchy of needs and corresponding strategic policy formulations at each hierarchical level. Supplementing the objectives, each role and contribution in implementing the strategies and policies will be discussed in light of the sustainable development of the industries. Since the survey required strong support of literature to establish CE as the best alternative to sustainable tourism, a descriptive methodology is expected to be most feasible. One of the key findings from the discussion is the identification of various strategies for sustainable tourism. Another interesting thing is the application of CE concepts, which delivers the best strategies to overcome the dynamic and complexity of the industries.

Stroke is one of the leading causes of mortality and disability worldwide, with ischemic stroke accounting for over 87% of all stroke cases. Chronic kidney disease (CKD) is one of the major risk factors for stroke, as CKD patients have shown evidence of impaired cerebral autoregulation leading to exacerbated stroke pathology. The worsening of stroke outcomes in CKD patients is limitedly understood. Inflammation plays a pivotal role in driving the CKD-stroke pathology. The cGAS-STING (cyclic GMP-AMP synthase-stimulator of interferon gene) pathway acts as a key mediator of inflammation in both pathologies. As mitochondrial dysfunction plays a common connecting link between stroke and CKD, activation of the innate-immune response mediated by cGAS-STING pathway becomes inevitable. Therefore, it becomes imperative to understand the role of mitochondria in the exacerbation of stroke outcomes following CKD. In addition, the critical role of altered immune response leading to exacerbated mitochondrial dysfunction and aging in CKD-stroke complex is also crucial to investigate. To study this, CKD was induced in male Sprague Dawley rats followed by middle cerebral artery occlusion (MCAo) to develop a CKD-Stroke complex animal model. Behavioral studies were conducted, and tissues were harvested for biochemical, histological, molecular, mitochondrial and genetic studies. Our findings from transcriptomic and proteomic analyses confirm upregulation of STING, interferons and related genes, alongside downregulation of mitochondrial health markers, in the CKD-stroke complex. This molecular profile reflects accelerated mitochondrial aging due to altered innate immunity mediated by cGAS-STING pathway.

Wetlands are the most important natural function of the terrestrial surface of the earth. It is a habitat of many aquatic plants and animals. On the other hand in industrialization is the processes of human development . In India the industrial activities have been rapidly increasing and urbanization process has also been fastest growing. Due to the industrial activities negative impacts on nature. In the study area the Duwani wetland is the most valuable and productive wetland of Assam. Because this natural wetland is connected with the mighty Brahmaputra river. The industrial activities on the bank of this wetland have mostly polluted the soil function. In this research works soil quality of the wetland is tasted on laboratory. Various parameters have taken for analysis. Some of the parameters like Potential of Hydrogen (pH), Electrical Conductivity (EC), Organic Carbon (OC), Nitrogen ( N), Potassium ( K), Phosphorus (P), Chloride (Cl ) etc. The soil samples are measuring both the WHO and USPH standard. From this analysis have found the amount of soil pollution and functional ecosystem of Duwani wetlands

ABSTRACT A simple and environmentally benign catalyst‐free protocol has been developed for the one‐pot synthesis of 1‐(benzothiazolylamino)methyl‐2‐naphthol derivatives from β‐naphthol, benzothiazole‐2‐amine, and aldehydes in ethanol under reflux, affording good to excellent yields (62%–94%). Detailed NMR analysis provided the first correct structural assignment and revealed an unusual downfield shift of the benzylic CH proton (∼7.26 ppm), attributed to magnetic anisotropy effects. Molecular docking against EGFR (PDB ID: 8SC7) showed favorable binding energies ranging from –8.11 to –10.79 kcal mol − 1 , with compounds 4c and 4k exhibiting the highest affinities. Key hydrogen bonding, hydrophobic, and π‐cation interactions with active‐site residues support their potential as EGFR‐targeted anticancer candidates.

ABSTRACT In this research work, an optical sensor based on donor‐acceptor Schiff base fluorescent chemosensor namely (E)‐4‐(4‐(diethylamino)‐2 hydroxy benzylidene amino)‐2‐(triflromethyl) benzonitrile) ( HL ) was successfully designed and developed for detecting three most essential and abundantly found elements namely Fe 3+ , Zn 2+ , and Cu 2+ . In absorption spectra, HL shows a drastic change in color with a possible to have naked eye detection with Fe 3+ whereas a noticeable isosbestic point was occurred with Zn 2+ . In emission spectra, fluorescence “on‐off” response with Zn 2+ and Cu 2+ was observed which indicates selectively senses of Zn 2+ and Cu 2+ . This sensor displays 2:1 stoichiometric ratio with metal ions by 1 H NMR titration, mass spectra and Job's plot. Moreover, the recyclability of HL was assessed through EDTA showing an efficient fluorescence “off‐on‐off” signal response. Furthermore, the (HL‐Zn 2+ ) ensemble formed was used for selective recognize MnO 4 − . HL achieved an INHIBIT logic function using different inputs and corresponding emission as output. The optimized structures of HL and complexes (HL‐Zn 2+ and HL‐Cu 2+ ) were used to understand spectral properties using DFT which further calculated different reactivity descriptors such as chemical hardness, chemical potential and electrophilicity index. This selective sensitivity of HL towards Zn 2+ were successfully studied and used for detection of Zn 2+ intracellularly in mouse breast adenocarcinoma cell.

The Indian Knowledge System (IKS) represents a vast body of indigenous knowledge encompassing philosophy, medicine, agriculture, ecology, and socio-cultural practices developed over centuries in the Indian subcontinent. In recent years, increasing global attention toward sustainability and indigenous knowledge frameworks has led to growing scholarly interest in IKS. This study presents a systematic literature review and bibliometric analysis of research on Indian Knowledge Systems published between 2015 and 2026. Bibliographic data were retrieved from the Scopus database using predefined search criteria. A total of 5866 records were initially identified, which were refined to 889 documents after applying inclusion criteria related to subject area, document type, language, and country affiliation. The study followed the PRISMA 2020 framework for systematic screening. Bibliometric analysis was conducted using VOSviewer to examine publication trends, keyword co-occurrence, collaboration networks, and citation patterns. The results indicate a substantial increase in IKS-related publications after 2019, reflecting growing academic and policy interest in indigenous knowledge frameworks. Major research themes include indigenous knowledge, sustainable development, ethnobotany, medicinal plants, and knowledge management. The findings highlight the interdisciplinary nature of IKS research and its increasing relevance in addressing global challenges related to sustainability, cultural preservation, and knowledge integration. This study provides a comprehensive overview of research trends, influential contributors, and emerging themes in the field of Indian Knowledge Systems.