Atlantic School of Theology

Introduction Antidysrhythmic medications are commonly prescribed, but there is little information on the incidence of adverse effects following an inadvertent extra dose of these medications. This poses a challenge to poison centers when trying to decide which patients need to be sent to a healthcare facility for monitoring. Methods A retrospective data review of cases reported to a regional poison center between January 1, 2012 and December 31, 2022 was performed. Cases were included if the exposure was a double dose or less of the patient’s own antidysrhythmic medication, the exposure was unintentional or a result of therapeutic error, and the antidysrhythmic(s) belonged to Vaughan Williams Class I or III. Cases were included even if other medications were included in the therapeutic error. Descriptive data were collected on cases meeting the inclusion criteria. Results One hundred and sixty-two exposures were included. Of these, only 49 were monitored in a healthcare facility for which coded outcomes were available. Of these, the majority had no or minor effects (83.7%). Two of the exposures developed hypotension, but both also involved either a beta-adrenoceptor blocking drug or a calcium-channel blocker. Of the 25 cases that only included an antidysrhythmic, adverse effects were even less common, with 92.0% having no or only minor effects. Discussion In this small cohort, adverse events were uncommon with inadvertent extra dose antidysrhythmic exposures. However, serious outcomes have been reported in other studies. It appears adverse events are less common if the extra dose exposure does not involve other cardioactive medications. Conclusions Extra-dose exposures of some antidysrhythmics belonging to Vaughan Williams Class I or III were generally well tolerated, but more data are needed to determine whether certain patients can be safely monitored at home. For example, only three cases involved Class IA drugs. Based on our findings, patients who reportedly ingest an extra dose of an antidysrhythmic plus another cardioactive medication should be evaluated at a healthcare facility.

"Arm in Arm with Adolescent Girls: Educating into the New Creation." Religious Education, 117(3), pp. 263–264

Terms used to label types of clinical recommendations and guidance are applied inconsistently and do not reflect the methods used to create each type. Here, the international Pediatric Oncology Supportive Care Guideline Network proposes a lexicon for types of recommendations and guidance documents. A lexicon describing three types of recommendations (clinical practice guideline-derived, good practice statement, and expert opinion statement) and two types of guidance documents (clinical practice guideline and expert opinion) is presented. Consistent use of this lexicon will allow pediatric oncology clinicians to readily appreciate the methods used to create clinical guidance.

ABSTRACT The most destructive psychological structures are made all that more lethal by their invisibility. This article explores one such structure, transference neurosis. Transference neurosis occurs when an individual is infected by the neurosis of another person, thus altering the normal defense patterns and causing a distortion in the unconscious. The therapeutic journey is charged with the task of addressing the primary injury as well as the foreign structure within the unconscious. The article will utilize the wisdom of Saint Paul, Charles Dickens, Sigmund Freud, Habib Davanloo and a case vignette in an effort to unmask and treat this destructive force.

Three Caribbean scholars, two Womanist Theologians and a Sociologist, collaborate to examine girl gangs and female gangsters in Jamaica for similarities with female soldiers in war or armed conflict elsewhere. They review the rise of female membership in gangs and the literature on particular issues involved as girls are victims and perpetrators of violence. They challenge gender framing that poses girls’ relative propensity to violence vis-a-vis boys who are expected to be violent. Utilizing informants with experience working with girl gang members, they explore gender dynamics at work in gang activity and violence. They suggest theological and ethical insights and the potential of religion to contribute to expanding community self-advocacy.

Oxysterol binding protein (OSBP)-related protein 4L (ORP4L, also known as OSBPL2), a closely related paralogue and interacting partner of OSBP, binds sterols and phosphatidylinositol 4-phosphate [PI(4)P] and regulates cell proliferative signalling at the plasma membrane (PM). Here, we report that ORP4L also interacts with the trans-Golgi network (TGN) in an OSBP-, sterol- and PI(4)P-dependent manner. Characterization of ORP4L lipid and VAP binding mutants indicated an indirect mechanism for translocation to ER-Golgi contact sites in response to 25-hydroxycholesterol that was dependent on OSBP and PI(4)P. shRNA silencing revealed that ORP4L was required to maintain the organization and PI(4)P content of the Golgi and TGN. In contrast, the interaction of ORP4L with the PM was not dependent on its sterol, PI(4)P or VAP binding activities. At the PM, ORP4L partially localized with a genetically encoded probe for PI(4)P but not with a probe for phosphatidylinositol 4,5-bisphosphate. We conclude that ORP4L is differentially localized to the PM and ER-Golgi contacts sites. OSBP-, lipid- and VAP-regulated interactions of ORP4L with ER-Golgi contact sites are involved in the maintenance of Golgi and TGN structure.

Traditionell versteht man unter Verbundgläsern Laminate, die aus mindestens zwei Glasscheiben bestehen und durch eine polymerbasierte, als Folie oder Flüssigkomponente eingebrachte Zwischenschicht verbunden sind. Die Zwischenschicht erweitert das Eigenschaftsspektrum von Glasprodukten erheblich. Das Flüssig‐Laminationsverfahren wird als Alternative zum Autoklavenprozess mit Folienmaterialien immer beliebter, da verschiedene technische und visuelle Anforderungen leichter oder auch überhaupt nur damit zu erreichen sind. Ein Anwendungsfeld sind Verbunde von Glas mit anderen Werkstoffen, beispielsweise mit Produkten wie Naturstein oder Keramik. Hier kommt der Vorteil zum Tragen, dass bei der Lamination mit Liquid Composites weder hohe Temperaturen noch erhöhte Drücke notwendig sind, unter denen die z.T. filigranen Steinplatten geschädigt werden können. Der vorliegende Beitrag beleuchtet die Entwicklung eines Liquid‐Composites‐Systems, mit dem beide Werkstoffe sowohl dauerhaft, bruchfest und in visuell einwandfreier Qualität zusammengefügt als auch anschließend im Verbund verarbeitet werden können.

"Baptist Identity and the Ecumenical Future: Story, Tradition, and the Recovery of Community by Steven R. Harmon." Toronto Journal of Theology, 33(2), pp. 311–312

William A. Wright, Pastor and Theologian in Residence of Church of Christ Congregational in Massachusetts and Associate Professor of Religion at Eureka College in Illinois, has written a complex and layered proposal for a new approach to theological writing that he terms ‘theography’. By turns obscure, brilliant, and provocative, this monograph presses the reader to reconsider the nature of theological writing and to do so via excursions into Calvin’s treatment of the doctrines of justification and sanctification. Those who read this book hoping for a clear and sustained focus on Calvin’s contribution may be disappointed. Wright, somewhat ambitiously, has three objectives, all of which he seeks to execute simultaneously. He sets out, first, to describe and to model theography, a self-reflexive and appropriately restrained mode of theological writing that both engages and is critical of academy, church, and the intersectional location of the seminary. Secondly, he explores Calvin’s understandings of soteriology both in a genuine effort to explain them and, in explaining them, to illustrate how theography unfolds. Finally, Wright accesses Hegel and Derrida’s contributions on dialectic and différence to broker the tensions within Calvin’s work and to model the kind of academic writing Wright wishes to commend to his readers. He calls this last move ‘an investigation into abstruse modern philosophers’ and an ‘outlandish, homeopathic remedy’ to the problems inherent in Calvin’s text (p. 43).

One intriguing cultural phenomenon today is changes in language. While language has always evolved, there is an emerging linguistically based cultural wisdom that is worthy of exploration in theology. The Urban Dictionary contains thousands of entries; words and phrases perhaps unknown a decade or so ago. Some of these have crept into mainstream English, while others fall into a category that might be reckoned as “street wisdom.” Many new words have been born from technology, social networking and globalization, as words and wisdom cross cultures and are highly influential in the worldviews of young people. The Urban Dictionary website boasts that this is “the dictionary you wrote” and tells people to “define your world.” The implicit claim is that we are no longer bound by traditional language and meanings and that we can name reality for ourselves.