Ayush & Health Sciences University Chhattisgarh

Background Despite growing scientific evidence and health guidelines, the global health paradox persists, with rising lifestyle-related diseases and escalating healthcare costs exposing the inadequacy of current efforts. Objective Three multidisciplinary congresses were held to generate evidence-based conclusions aimed at addressing the global health paradox. Methods A total of 58 experts from 62 entities participated in the international research and knowledge-exchange panels. Experts reviewed the latest findings to develop practical strategies and identify key research and policy priorities, focusing on the Healthy Eating & Active Living (HEAL) approach. Results, conclusion, and relevance The expert consortium endorsed a 33 evidence-based consensual-statement policy roadmap for addressing global health challenges, emphasizing that the HEAL approach can significantly contribute to the “Prevention First” appeal and broad ethical, social, ecological, and economic advantages, and ultimately supporting policy change.

Diabetes mellitus (DM) and hypertension frequently coexist and together substantially increase the risk of cardiovascular morbidity, mortality, and healthcare burden worldwide. Despite growing recognition of their shared pathophysiology, clinical management often remains fragmented, creating uncertainty regarding the optimal integration of care strategies. This systematic review aimed to synthesise current evidence on integrated management approaches for adults with coexisting DM and hypertension, with emphasis on intervention models and clinical outcomes. A systematic literature search was conducted in PubMed, Scopus, and Web of Science for studies published between 2015 and 2025. Eligible studies included randomised controlled trials and comparative observational studies evaluating integrated or combined management strategies. Eleven studies met the inclusion criteria and were synthesised systematically due to heterogeneity in study designs and outcome reporting. Integrated interventions commonly combined pharmacological optimisation, lifestyle modification, multidisciplinary team care, and technology-assisted support. Reported outcomes included improvements in glycaemic control, blood pressure regulation, cardiometabolic risk factors, and care process indicators. The findings highlight the consistent application of coordinated care frameworks across diverse healthcare settings, reflecting a shift toward comprehensive cardiometabolic risk management. Integrated strategies demonstrate potential to enhance care coordination, patient engagement, and alignment with patient-centred care models. The evidence supports integrated management as a viable and clinically relevant approach for addressing the complex needs of individuals with coexisting DM and hypertension, reinforcing the importance of coordinated strategies in contemporary chronic disease management.

Herbal formulations are now widely accepted as effective treatment options for a number of illnesses. One of the biggest challenges facing scientists in the present day is the development of reliable, authentic analytical techniques that can profile the phytochemical composition. These techniques include quantitative assessments of marker/bioactive chemicals and other important ingredients. Establishing a standardized biological activity, chemical profile, or even just a quality assurance programme for the manufacture and manufacturing of herbal medications requires standardization. It is crucial to follow WHO-specific protocols for evaluating the quality, safety, and efficacy of herbal medications before attempting universal harmonization. An overview of the many methods used for standardizing herbal nanomedicines and for extracting and characterizing herbal medications is presented. Furthermore, reports have been made regarding the enhanced bioavailability of phytosomes, the potential of metabolomics in the creation of better phytotherapeutic agents, the use of bhasma as a metal nanocarrier drug delivery system, the use of DNA-based molecular markers to identify adulterants, and the use of SCAR markers to authenticate and separate herbs from their adulterants. There is a discussion of how high-value herbal compounds can be extracted from herbal medications using supercritical phase extraction and microwave-assisted extraction technology. Standardization can then be achieved through the use of various thermogravimetric, chromatographic, and spectroscopic techniques, either separately or in combination. It is also reported that polarographic methods and capillary electrophoresis have contributed to the standardization of herbal medications. Chinese herbal medicines with a nanotechnology foundation are more bioavailable and have better solubility.

Therapeutic effects of PRP are well proven. The only drawback is the extracted quantity is very less. Moreover, the PRP, PPP or fibrin mesh disintegrates within 48 to 72 hours, leaving the bone graft particles dispersed at the site of application. Their results are very predictable in the areas where the primary closure of the wound is possible. I am not convinced by the use of fibrin mesh for covering the defects. I feel the necessity of mention of defect sizes which you included in this study.

Background: Chronic kidney disease associated pruritus (CKD-ap) and xerosis is intensely annoying and unpleasant manifestations associated with maintenance renal dialysis (MRD) among chronic kidney disease (CKD) patients. It severely compromises the quality of life by disturbing normal sleep pattern and also adversely affect the mental health in CKD patients. Many proposed treatment plan for CKD –ap is tested but none of the treatment plan provide complete relief from itch associated with MRD. Glycerine accelerate barrier repair and also has rapid hydrating and smoothing effect while Paraffin preserve the barrier function against irritant. As a comparator Mustard oil is used as it is commonly used home remedy by people in Indian sub-continent for dry skin.
 Objectives: The primary objective of the study is to compare the efficacy of Glycerine –paraffin combination with mustered oil on skin related quality of life among CKD patients with CKD-ap and xerosis.
 Methodology: A randomised, single blind, controlled, clinical trial intending to investigate and compare the efficacy of Glycerine – Paraffin combination with mustard oil in CKD –ap and xerosis and overall SRQOL among CKD patients. The study aims to enrol 140 CKD patients having moderate to severe CKD-ap and xerosis by using GI gammal score (standardized tool for assessment of xerosis). They will be randomly distributed among 2 parallel group, experimental & control group. Allocation concealment will be maintained by using SNOSE technique. Experimental group will be instructed to apply glycerine paraffin combination and mustard oil to control group twice a day for 4 weeks. participant will be evaluated for xerosis and pruritus score at baseline, day 7, day 28 and day 56. Scores of SRQOL will be assessed at baseline and on 56 days. 
 Conclusion: The RCT aims to identify & compare the efficacy of Glycerine –paraffin combination with mustard oil on skin related quality of life among CKD patients with CKD-ap and xerosis.

The present study was performed with an objective to determine acaricidal activity of Citrus limetta seed oil (CLO) against cattle tick Rhipicephalus microplus. The mode of action of CLO was determined by evaluating biochemical enzymatic levels in treated ticks. CLO was obtained by extracting with n-hexane as solvent in soxhlet apparatus. The active compounds in CLO were analyzed through Gas chromatography. Acaricidal activity of CLO was evaluated using larval packet test (LPT) and adult immersion test (AIT). Results of chromatographic analysis showed that palmitic acid, stearic acid, α-Tocopherol and bergamol were present as major active constituents along with other compounds. The lethal concentration (LC50) of CLO was found to be 2.87% and 3.96% for larvae and adult of R. microplus ticks, respectively. In vitro acaricidal bioassay revealed 100% mortality of ticks in both LPT and AIT at 12.5% dose. CLO significantly (p < 0.001) reduced oviposition rate, hatching ability of eggs and reproduction efficiency of ticks. Biochemical analysis of ticks homogenate showed different enzymatic levels. The results revealed that CLO disturbed protective enzymes functions by reducing level of SOD, GST, MAO and AChE but increasing NOS level in ticks as compared with control group. Thus, CLO may be used as an effective acaricidal agent in controlling R. microplus ticks.

Croton tiglium seeds and Moringa oleifera leaves extracts are rich in phytoconstituents with the antioxidant efficiency which can be enhanced by incorporating silver nanoparticles (Ag-NPs). The present study was designed to compare the effect of C. tiglium seeds and M. oleifera leaves nano-extracts on brain tissues of murine models. During the current study, acetylcholine esterase (ACHE), β-amyloid (Aβ) content and inflammatory markers were measured in brain tissues. Moreover, native protein, lipoprotein and isoenzymes patterns were electrophoretically detected. Also, the interferon-gamma (INF-γ) receptor protein was studied by molecular dynamic simulation to evaluate the significant alterations on brain tissues. It was found that ACHE, Aβ contents and inflammatory markers increased in the C. tiglium nano-extract treated group at a dose of 6.5 ml/kg. Furthermore, it caused qualitative electrophoretic abnormalities represented by lowering similarity index (SI) values. Also, the resides range 119~127 represent the most reactive and flexible site in INF-γ receptor protein. On the other hand, it was shown that no significant differences were induced by silver M. oleifera nano-extract.

The varicose ulcer is the wound which occurs due to abnormal venous hypertension in the lower third of the leg ankle and dorsum of the foot. The pathogenesis starts with obesity and long standing due to dysfunction of venous valve causing venous hypertension around ankle lead to ulcer formation. If venous ulcer is not treated properly then it gets infected, leads to cellulitis and gangrene; so, may require amputation part of the limbs. The recurrence of venous ulcers is very common. The 70% of venous ulcer are healed within 12 weeks of period[1]. There are so many conservative managements in allopathy like, compression stocking, foot elevation, antibiotic and dressing of the wound which when fails may require surgical treatment like skin grafting, sclerotherapy, laser ablation. But its very costly and not much significant. In Ayurveda this disease can be correlated with sirajanya vran, dushta vran. A 32 years male patient having complaints of Nonhealing varicose ulcer over medial malleolus of bilateral leg since 10 months. Treatment like abhyanga , raktamokshana and dressing by using panchavalkal ointment given to patient. Significant healing of wound is observed and the complaints were gradually subsides. The wound were completely healed within 35 days of treatment.