Cargotec (Poland)

Abstract Background Porcine respiratory disease complex (PRDC) significantly impacts the global pig industry, causing substantial economic losses. This study aimed to quantify the effects of cranio-ventral pulmonary consolidation (CVPC) and pleurisy on carcass weight and meatiness in finishing pigs. We employed a mixed-model analysis to assess lung lesions at slaughter and their correlation with production parameters across seven pig farms. Results The mean prevalence of lesions was 23.8% for CVPC and 15.4% for pleurisy. Pigs with severe lung lesions (> 15.1%) showed significantly lower ADCWG compared to those without lesions (0.951 vs. 0.997 kg/day, p = 0.024). The mixed-effects model revealed that lesions in the right apical lobe and dorso-caudal pleurisy were associated with significant reductions in carcass weight (-2.77 kg and − 2.29 kg, respectively) and carcass meat (-1.76 kg and − 1.43 kg, respectively). An economic analysis under average market price conditions demonstrated that severe lung lesions could lead to losses of up to 11.53 EUR per affected pig. Conclusions This study provides quantitative evidence of the negative impact of CVPC and pleurisy on carcass weight and meatiness in finishing pigs. The findings underscore the importance of effective respiratory disease management in swine production, highlighting potential areas for targeted interventions to improve animal health and economic outcomes.

Thin wires of molybdenum coated with gold are used for space applications and the adhesion of the gold layer is decisive for their use. The surface morphology of the wires is determined by the manufacturing process and preferential orientation of single crystal surfaces is expected. In this work three different single crystal surfaces were studied together with a 20 μm molybdenum wire to elucidate the importance of surface morphology on the electrodeposition process for gold. Electrochemical impedance spectroscopy was used to study the molybdenum samples in the absence and presence of gold cyanide complexes. The results show large pseudocapacitance prior to gold deposition, indicating the presence of a thin molybdenum oxide film on the surface. Thus, the electrodeposition takes place on the surface oxide and is afflicted with a nucleation overpotential. The overpotential is only slightly dependent on the single crystal orientation, while it is more negative for the wire. The adhesion of gold on the flat single crystal surfaces is weak but marginally better on the wire. This clearly shows that strong chemical binding to the surface is absent and that other processes, such as physical interlocking of the gold layer is necessary for good adhesion.

The focus of this article is on digital tools as part of mathematics education with six-year-olds. More explicitly, we study how the creation of digital animations, as a part of working on a problem-solving task, enables young students’ learning of combinatorics. In the article, the creation of digital animations implies that the students re-design, that is, recreate their solution procedure with a digital application. The aim with letting the young students create digital animations is diverse. We presume that such work enables problem solving as well as the learning of combinatorics, but also that it has potential to enable creativity and agency in learning. Video-documentations from three classrooms where students work on the problem-solving task were analysed from a multimodal perspective where teaching is seen as a design process. In that process, the teacher designs learning activities that give students access to different resources for their meaning making process. The results show that working with digital animations, when integrated in a learning design sequence, amplify students’ learning of combinatorics.

Postoperative infection is a common healthcare-associated problem, and unfortunately, a serious complication in cardiac surgery patients. Toll-like receptors (TLRs) are crucial in activating non-specific immunity mechanisms and integrating elements of the immune system, due to interactions between specific and non-specific responses. In this study, the association of TLR2 or TLR4 with the risk of postoperative infections in cardiac surgery patients undergoing a coronary artery bypass grafting (CABG) procedures was investigated. Our research was carried out on a cohort of 299 consecutive adult patients with ischemic heart disease (IHD) who underwent a planned CABG procedure. These patients were monitored for the presence of a postoperative infection over a 30-day observation period. All patients were investigated for 2 TLR2 gene mutations - R753Q (rs5743708) and T16934A (rs4696482), and 2 polymorphisms of the TLR4 gene - D299G (rs4986790) and T399I (rs4986791). The final stage of the study was an evaluation of the hypothetical association between TLR2 and TLR4 gene variances and postoperative infections in patients undergoing CAGB procedures. The prevalence of infections in the final cohort was 15.3% (46/299). The most common infections were surgical site infections, which were diagnosed in 21 patients (45.6%), bloodstream infections in 15 patients (32.6%) and pneumonia in 10 patients (21.8%). Logistic regression demonstrated that the presence of the AG+GG of D299G (rs4986790) and CT+TT of T399I (rs4986791) variants was related to a higher incidence of infection in patients undergoing CAGB procedures. To our knowledge, this is the first study of its kind to demonstrate that TLR2 and TLR4 mutations affect the risk of post-CABG infections. Being a carrier of the AG+GG of D299G (rs4986790) or CT+TT of T399I (rs4986791), TLR4 variants constitute a postoperative risk factor for infection in patients undergoing CAGB procedures.

Billr egarding rescinding Jewish trading privilegesl apses. Billpreventing Jewish immigration and settlement without permission from the king; proposal foranew judereglementei sr ejected./ Demand thatp ermission for Jews to immigrate be granted as sparingly as possible. Demand thatJ ews be forbidden to buy real estatei nt he country and thatt he prohibition on their travelling and trading be renewed./ Bills demanding the expulsion of Jews from the countrya nd other measures arer ejected./ Demand for the right of those Jewish youngsterswho have the necessaryprivilegesto live in the countryt of requenta ll public educational institutions./ Demand thatn om orep ermissions be granted to travelling Jews to trade in trinkets and haberdashery./ Demand thatJews not be permitted to settle in the country, that the application of the constitution of  be halted, and that the judereglemente of  be reimplemented./ Billp rohibiting Jews from employing Christians in their servicei sr ejected./ Demand thatt he estates of the Empirep articipate in the legislation forJ ews./ Demand thatJ ews be granted the right to bear witness./ Billr egarding full civil rights forJ ews born in Swedenl apses./ Billr egarding extensions of those privilegest hatJ ews haveb een granted within the countryi sr ejected./ Demand thatJ ews born in Sweden can settle in all towns in the country./ Proposalt hat the kingm ay appoint people of non-lutheran faith as teacherso f handicrafts and art, declared resting./ The preceding proposal is rejected./ Proposalt oa llow callingp eople of the Jewishc onfession as members of aj ury./ Demand to allowJews to buy and own property in Sweden without special permission from the king./ Proposaltomodify § of the constitution, so thatJews might be granted the right to participatei ne lections fort he Riksdag, is declared resting./ The preceding proposal is rejected./ Constitution adopted regardingm arriages between Christians and Jews./ Proposaltomodify § of the constitution, so thatJews might be granted the right to participatei ne lections fort he Riksdag, is declared resting.

Objective: Recent NICE guidelines for management of hypertension stress the importance of home blood pressure management (HBPM) to confirm a diagnosis of hypertension. The objectives were to investigate the difference in two subsequent blood pressure (BP) measurements, evaluate diurnal variation using home blood pressure measurement and assess change in BP levels during a standard measurement period in home environment. Design and method: A total of 758 (male 372/female 386, mean age 57.9 ± 8.2 years) treated for primary hypertension were investigated. No intervention was given during the trial period. BP values were obtained by self-measurement at home using a Bluetooth-equipped oscillometric BP monitor connected to a smartphone application (Accumbo AB). For the first two weeks of the trial, participants were asked to measure HBPM on at least seven days in the morning (before breakfast) and at least seven days in the evening. Each measurement consisted of two BP measurements at 1-minute intervals. Results: The second/subsequent BP measurement showed lower values for both systolic BP (mean SBP 135 ± 12 mmHg vs. 134 ± 12 mmHg) and diastolic blood pressure (mean DBP 88 ± 9 mmHg vs. 87 ± 9 mmHg) compared with the first measurement (p < 0.001). Difference was more pronounced for SBP in males (-0.65 mmHg) than females (-0.52 mmHg), (p < 0.05). Diurnal BP variation was non-significant for SBP (p = 0.18) while DBP showed higher values in the morning (89 ± 9 mmHg) compared with evening values (86 ± 9 mmHg), (p < 0.001). The BP morning surge was more pronounced for males vs. females (p < 0.001). Mean BP was lower during the second week (134/87 ± 12/9 mmHg) compared with the first week (135/88 ± 12/9 mmHg, p < 0.001). This difference was driven by a reduction in BP significant for women (p < 0.001), but not for men (p = 0.37). Conclusions: The results indicate significant gender related differences in subsequent blood pressure values over time which might affect decision for treatment. The guidelines for home blood pressure monitoring may need to be revised to include more measurements over a longer period considering gender affiliation.

Abstract Background: Patients with eating disorders have reported poorer emotional awareness, more emotional suppression, less use of adaptive emotional regulation strategies, and more use of maladaptive emotional regulation strategies compared to people in healthy control groups. Aim: To explore experiences of emotions by a transdiagnostic sample of patients with eating disorders. Method: Nine patients with different eating disorder diagnoses at an eating disorder outpatient clinic in Sweden were interviewed for their thoughts on emotions. The interviews were analyzed with Thematic Analysis. Result: Four themes were constructed: "Not knowing what one feels", "Switch off, run away, or hide behind a mask", "Emotions in a lifelong perspective", and "Using eating behaviours to regulate emotions". The patients described uncertainty regarding whether they experienced emotions correctly. They described how they tried to avoid difficult emotions through suppressive strategies and eating disorder behaviour. All described strategies were inefficient and all emotions were experienced as problematic, even joy. Since joy was used as a mask, the real experience of happiness was lost and mourned. Conclusion: All kinds of emotions were considered problematic to experience, but shame, fear, and sadness were considered worst. It is difficult to know if the emotional difficulties preceded an eating disorder, however such difficulties may have increased as a result of the eating disorder.

This study is an exploration of lived religion and gender across the Reformation, from the 14th–18th centuries. Combining conceptual development with empirical history, the authors explore these two topics via themes of power, agency, work, family, sainthood and witchcraft. By advancing the theoretical category of ‘experience’, Lived Religion and Gender reveals multiple femininities and masculinities in the intersectional context of lived religion. The authors analyse specific case studies from both medieval and early modern sources, such as secular court records, to tell the stories of both individuals and large social groups. By exploring lived religion and gender on a range of social levels including the domestic sphere, public devotion and spirituality, this study explains how late medieval and early modern people performed both religion and gender in ways that were vastly different from what ideologists have prescribed. Lived Religion and Gender covers a wide geographical area in western Europe including Italy, Scandinavia and Finland, making this study an invaluable resource for scholars and students concerned with the history of religion, the history of gender, the history of the family, as well as medieval and early modern European history. The Introduction of this book is freely available as a downloadable Open Access PDF under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license and is available here: https://tandfbis.s3-us-west-2.amazonaws.com/rt-files/docs/Open+Access+Chapters/9781351003384_oaintroduction.pdf

Boka En kort introduksjon til korstogene er eit kjærkome tilskot til den norske bokheimen. Dette skuldast fyrst og fremst at boka er velskriven og informativ, og den klarar å gje ei oversikt over eit svært komplekst historisk tema på ein lettfatteleg måte. Trass at forfattaren tek føre seg ein periode som strekkjer seg over fleire hundre år, kan lesaren likevel navigere seg gjennom materialet på ein rimeleg god måte (sjølv om der er enkelte strukturelle val som eg skal kome attende til). I tillegg fyller boka eit betydeleg hol i det tilgjengelege norskspråklege akademiske materialet, då den ikkje berre gjer norske lesarar kjende med den fulle geografiske breidda i krosstogsfenomenet, men òg fordi Svenungsen gjev ei solid framstilling av dei skandinaviske rika si rolle gjennom hundreåra. Ein tredje grunn til at boka er så kjærkoma er dessutan at den er relevant for våre eigne dagar, ettersom krosstogstematikk og -symbolbruk er noko som er veldig populært blant militante grupper på høgresida. Svenungsen inkluderer også ein diskusjon omkring dette aspektet ved krosstoga si historie, og det vert derfor lett å forstå kva rolle vår eiga oppfatning av historia spelar i måten vi brukar, eller som i dette tilfellet, misbrukar ho på.

HIV coinfection is the greatest risk factor for transition of latent Mycobacterium tuberculosis infection into active tuberculosis (TB). Epidemiological data reveal both the reduction and the impairment of M. tuberculosis-specific CD4 T cells, although the cellular link and actual mechanisms resulting in immune impairment/suppression need further characterization. M. tuberculosis-specific CD4 T cells play a central role in development of protective immunity against TB, in which they participate in the activation of macrophages through the dendritic cell (DC)-T cell axis. Using an in vitro priming system for generating Ag-specific T cells, we explored if HIV-M. tuberculosis-infected (coinfected) human DCs can dysregulate the M. tuberculosis-specific CD4 T cell phenotype and functionality and subsequently mediate the failure to control M. tuberculosis infection in macrophages. After coculture with coinfected DCs, M. tuberculosis Ag-specific CD4 T cells lost their ability to enhance control of M. tuberculosis infection in infected macrophages. Coinfection of DCs reduced proliferation of M. tuberculosis Ag-specific CD4 T cells without affecting their viability, led to increased expression of coinhibitory factors CTLA-4, PD-1, and Blimp-1, and decreased expression of costimulatory molecules CD40L, CD28, and ICOS on the T cells. Expression of the regulatory T cell markers FOXP3 and CD25, together with the immunosuppressive cytokines TGF-β and IL-10, was also significantly increased by coinfection compared with M. tuberculosis single infection. Our data suggest a pattern in which HIV, through its effect on DCs, impairs the ability of M. tuberculosis-specific CD4 T cells to maintain a latent TB within human macrophages, which could play an early role in the subsequent development of TB.