Centro Universitário São Camilo

As tentativas de autoextermínio configuram-se como importante problema de saúde pública e representam demanda frequente e complexa nos serviços de urgência e emergência, que, muitas vezes, constituem o primeiro ponto de contato dessas pessoas com o sistema de saúde. Nesse contexto, a qualificação do cuidado e a atuação integrada das equipes tornam-se fundamentais para além da estabilização clínica imediata. Objetivo: Analisar as evidências científicas disponíveis sobre o manejo multiprofissional de pessoas vítimas de tentativas de autoextermínio no contexto dos serviços de emergência. Método: Trata-se de uma revisão integrativa da literatura, conduzida segundo as recomendações do PRISMA 2020 e do Joanna Briggs Institute, com buscas em bases de dados nacionais e internacionais. Foram incluídos estudos que abordassem estratégias assistenciais, organização dos serviços e intervenções no cuidado a pessoas em situação de crise psíquica atendidas na emergência. Resultados: Os achados evidenciam a importância de fluxos assistenciais organizados, avaliação ampliada, acolhimento qualificado e atuação integrada entre diferentes profissionais, bem como do seguimento estruturado após a alta. Conclusão: O manejo multiprofissional deve ser compreendido como processo articulado, envolvendo organização dos serviços, práticas colaborativas e integração com a rede de atenção psicossocial.

Purpose To describe the development of a healthy eating habits intervention in a school and to evaluate parents’ acceptability of this initiative. Design/methodology/approach This exploratory study was conducted between February and March 2022 in a public school serving children aged 1–4 years in São Paulo, Brazil. The school acted as an educational distribution channel. Interviews with school staff helped co-design four educational videos with seasonal recipes. These were matched with boxes of local vegetables (that would otherwise have been wasted by a local vegetable grower) and delivered to parents (matching ingredients to recipes). Qualitative analysis was conducted to evaluate parental acceptability of the intervention. Findings The intervention was well-received. All parents liked the videos, 74% used most of the fruits and vegetables provided and 83% tried the recipes. However, 30% suggested reducing the amount of leafy greens, as their children tended to avoid them. Originality/value This pilot intervention was feasible and appreciated by parents, indicating potential for adaptation in similar educational contexts. It contributes to the literature by testing a co-designed, school-based food education strategy in a low-income setting and emphasises the importance of integrating school and home environments to foster healthier eating habits. Further research is needed to assess long-term impacts and scalability.

Long COVID is a complex condition characterized by persistent symptoms following SARS-CoV-2 infection. Understanding its biochemical mechanisms is essential for effective management and treatment strategies. Objective: This study investigated biochemical alterations associated with long COVID in unvaccinated individuals presenting symptoms persisting for more than six months, highlighting the prolonged nature of the condition and its systemic and neurological manifestations. A cross-sectional study was conducted with 60 unvaccinated patients at least six months post-COVID-19 infection. Serum biomarkers, including C-reactive protein (CRP), interleukin-6 (IL-6), N-terminal pro-brain natriuretic peptide (NT-proBNP), and irisin, were analyzed. Correlations between these biomarkers and persistent symptoms were assessed using statistical regression models. Elevated CRP levels were significantly associated with persistent respiratory and musculoskeletal symptoms, suggesting ongoing inflammation. Increased IL-6 levels correlated with fatigue and musculoskeletal complaints. NT-proBNP elevations were linked to cardiovascular manifestations, including dyspnea and chest pain. A positive correlation between irisin and persistent sensory impairments, such as anosmia and dysgeusia, indicates potential neuroinflammatory mechanisms. This study highlights that persistent inflammation plays a critical role in long-term (>6 months) post-COVID manifestations. Monitoring biomarkers such as CRP, IL-6, NT-proBNP, and irisin may enhance understanding and management of prolonged post-COVID conditions.

Introduction: The pes anserinus corresponds to the conjoined insertion of the sartorius, gracilis, and semitendinosus muscle tendons on the anteromedial aspect of the proximal tibia. These tendons are widely used as autologous grafts in anterior cruciate ligament (ACL) reconstruction procedures. However, anatomical variations and insufficient knowledge of this region may contribute to surgical complications and graft harvesting failures. Objective: To provide detailed knowledge of this medial knee region in fetuses and the possible anatomical variations of the tendons to assist in reducing surgical complications. Methodology: Forty lower limbs from 20 human fetal cadavers (20 right limbs and 20 left limbs), with an average gestational age of 27.94 weeks, were dissected. Morphometric measurements of the muscle bellies and tendons forming the pes anserinus were obtained. Results: Measurement of the muscles forming the pes anserinus revealed that the sartorius muscle presented the largest mean value for the muscle belly (66.10 mm), while the semitendinosus muscle tendon demonstrated the greatest mean length (31.70 mm). In 5% of cases (n=2), a common tendinous attachment for the gracilis and semitendinosus muscles was observed. Additionally, accessory tendinous attachments were found in 52.5% (n=21) of cases, restricted to the gracilis and semitendinosus muscles. Conclusion: The detailed anatomical and morphometric data provided by this study contributes to a better understanding of the fetal development of the pes anserinus and may help reduce technical failures during the harvesting of autologous grafts in ligament reconstruction procedures.

O uso de Esteroides Anabolizantes Androgênicos (EAA) tem se consolidado como um importante problema de saúde pública, especialmente em virtude de seus efeitos neuropsiquiátricos potencialmente graves e ainda subestimados. Este estudo teve como objetivo revisar criticamente a literatura científica recente acerca da associação entre o uso de EAA e o desenvolvimento de sintomas psicóticos, abordando aspectos epidemiológicos, clínicos, neurobiológicos e terapêuticos. Trata-se de uma revisão narrativa da literatura, baseada em artigos publicados entre 2015 e 2025, indexados nas bases PubMed, SciELO, PsycINFO, Web of Science e Google Scholar. Os resultados demonstram que o uso de EAA, sobretudo em doses suprafisiológicas e esquemas prolongados, está associado a maior incidência de sintomas psicóticos, incluindo mania, hipomania, delírios paranoides, alucinações, agressividade e delirium, podendo ocorrer mesmo em indivíduos sem histórico psiquiátrico prévio. Evidências de estudos clínicos, de coorte e de neuroimagem indicam que esses efeitos são dose-dependentes e mediados por alterações estruturais e funcionais cerebrais, especialmente envolvendo a amígdala, o córtex cingulado anterior e os sistemas dopaminérgico, serotoninérgico e glutamatérgico. Além disso, aproximadamente 30% dos usuários desenvolvem dependência de EAA, com elevado risco de depressão grave e ideação suicida durante a abstinência. Conclui-se que os sintomas psicóticos induzidos por EAA representam uma condição clínica relevante, exigindo reconhecimento precoce, abordagem multidisciplinar e estratégias preventivas e terapêuticas baseadas em evidências, com implicações diretas para a prática clínica e para políticas públicas de saúde mental.

The potential adverse effects, including systemic reactions, of some organic filters used in sunscreens have driven the search for alternatives. Brazilian green propolis, rich in polyphenols, shows promise in absorbing ultraviolet (UV) radiation and acting as an antioxidant in photoprotective formulations, allowing for a reduction in the concentration of organic filters while maintaining photoprotection efficacy. Oil-in-water emulsions were prepared containing chemical UV filters-ethylhexyl methoxycinnamate and butyl methoxydibenzoylmethane-with or without the addition of Brazilian green propolis extract at concentrations of 2.5% and 5.0% (w/w), along with a blank formulation as control. These formulations were assessed for antioxidant activity, photoprotective efficacy (in vitro and in vivo methods), photostability, inhibition of lipid peroxidation in the stratum corneum of human volunteers, and skin permeability. The addition of green propolis extract significantly enhanced both the antioxidant activity and sun protection factor (SPF) of the formulations without significant penetration, making it an excellent alternative to partially replace organic filters. In vitro photoprotective efficacy parameters met broad-spectrum sunscreen standards, providing good to excellent ultraviolet A (UVA) protection. However, the low photostability of the formulations limited the extract's ability to protect the stratum corneum from lipid peroxidation. Therefore, Brazilian green propolis serves as a promising adjuvant in sunscreen formulation, boosting efficacy while ensuring formulation safety.