Centro Universitário de Várzea Grande

Intensive management and dependence on phosphate fertilizers in agricultural systems, such as corn, have significantly increased production costs. As a alternative, the use of phosphorus-solubilizing microorganisms has emerged as a sustainable biotechnological strategy, aiming to optimize phosphorus bioavailability in the soil. Therefore, this study aimed to evaluate the effect of inoculating previously selected bacteria with phosphorus-solubilizing capacity on promoting corn plant growth. The experiment was conducted in a greenhouse at the UNIVAG Experimental Field, in a completely randomized design, with 11 treatments: nine bacterial isolates (VG09, VG27, VG42, VG46, VG47, VG68, VG82, VG89, and VG91), NPK fertilization, and a control without fertilization, with five replicates. Forty days after emergence, the following parameters were evaluated: root length (cm), plant height (cm), stem diameter (mm), and fresh and dry weight of shoots and roots (g). Isolate VG09 and the NPK treatment performed best in six of the seven parameters evaluated, followed by isolates VG27 and VG91, which excelled in five. The results demonstrate that the application of technologies based on beneficial microorganisms is a promising path for modern agriculture. The use of phosphorus-solubilizing bacteria not only increases corn productivity but also offers a means to reduce dependence on chemical inputs, encouraging the adoption of more stable, efficient, and competitive production systems.

O envelhecimento feminino, particularmente durante a transição menopausal, está associado a alterações hormonais que intensificam processos inflamatórios e desfechos cardiometabólicos. Esta revisão objetiva analisar a relação entre a terapia hormonal, a menopausa, o estilo de vida e o risco cardiometabólico em ensaios comunitários controlados. Consiste em uma revisão integrativa da literatura, desenvolvida a partir de buscas realizadas em dezembro de 2025 nas bases de dados LILACS, MEDLINE e PubMed.Os estudos mostram que a combinação entre terapia hormonal e mudanças no estilo de vida reduz o risco cardiometabólico em mulheres na menopausa. Os melhores resultados ocorrem com indicação adequada, início oportuno e abordagem multiprofissional, favorecendo adesão e melhores desfechos em saúde. Assim, a combinação entre a terapia de reposição hormonal e intervenções no estilo de vida promove benefícios consistentes na redução do risco cardiometabólico em mulheres na menopausa, sobretudo quando a terapia é indicada de forma adequada e iniciada precocemente. Essa estratégia integrada mostra-se viável em contextos comunitários e reforça a importância de abordagens individualizadas e multiprofissionais para a promoção do envelhecimento saudável.

Introduction: Movement disorders such as Parkinson’s disease (PD), atypical parkinsonian syndromes, and dystonia (DT) impair motor control and significantly affect quality of life. Spinal cord stimulation (SCS), traditionally indicated for refractory chronic pain, has emerged as a promising therapeutic option for motor symptoms, especially in patients refractory or ineligible for deep brain stimulation (DBS). This study aims to systematically review the efficacy of SCS in these disorders, assessing benefits, limitations, and current evidence.Method: A systematic review following the PRISMA protocol was conducted. Databases PubMed, Embase, Scopus, Web of Science, Virtual Health Library (BVS/LILACS), and Cochrane were searched using descriptors in Portuguese and English such as “Spinal Cord Stimulation,” “Parkinson’s Disease,” “Dystonia,” and “Parkinsonian Syndromes.” Studies involving humans and animal models addressing SCS as a primary or adjuvant treatment were included. Studies focused exclusively on pain, other pathologies, inaccessible articles, and publications older than 20 years were excluded. Two independent reviewers performed screening on the Rayyan platform. Due to methodological heterogeneity, data analysis was qualitative.Result: A total of 61 studies were included. For PD, 46 publications were analyzed: 21 case reports, 18 case series, 2 case-control studies, and 5 preclinical studies. SCS demonstrated benefits particularly in axial symptoms such as freezing of gait (FoG), postural instability, and bradykinesia. Optimal results were observed with high-frequency stimulation (above 130 Hz) or burst mode, with implants preferably at high thoracic or cervical levels. In atypical parkinsonian syndromes, 10 studies were found (7 case reports and 3 case series) showing preliminary evidence of transient improvement in symptoms such as dysarthria, gait, and posture, especially in patients with multiple system atrophy (MSA). However, effects were limited by the small number of publications, short follow-up, and rapid disease progression. In DT, only 5 studies were identified (4 case reports and 1 case series), mostly predating DBS as the standard treatment. Isolated results, such as in complex regional pain syndrome associated with DT, suggest clinical improvement with SCS, indicating potential use as alternative or adjuvant therapy in specific contexts.Discussion: SCS emerges as a less invasive approach for patients with unsatisfactory response to conventional treatments. Its mechanism likely involves modulation of proprioceptive pathways and cortico-subcortical circuits, although pain relief may confound motor symptom assessment. Challenges include interindividual response variability, lack of standardized stimulation parameters (frequency, mode, implantation site), and scarcity of high-quality controlled studies. Burst stimulation is notable for its positive effects on symptoms such as FoG and tremor.Conclusions: SCS is a promising therapy for PD, parkinsonian syndromes, and DT, with benefits on motor symptoms and quality of life. Despite growing evidence, randomized controlled clinical trials are needed to validate efficacy, define optimal stimulation parameters, and elucidate mechanisms of action.

To identify the epidemiological and clinical characteristics of patients with post-Chikungunya chronic inflammatory joint disease. A cohort study was conducted with 226 patients with post-Chikungunya chronic inflammatory joint disease (pCHIKV-CIJD), treated between July 2017 and January 2023 at the outpatient clinic of the University of Cuiabá, Mato Grosso. Patients were divided into two groups: Group 1 (73 patients presenting improved symptoms in the acute phase) and Group 2 (153 patients with persistent joint symptoms for > 3months). Epidemiological, clinical, and laboratory data were collected; disease activity was assessed by the Clinical Disease Activity Index (CDAI) during semiannual follow-ups along 24months. Most patients were middle-aged women (86.3%, mean 51.1years of age). Systemic arterial hypertension (hypertension: 26.5% versus 11.0%; p = 0.030) and osteopenia (8.3% versus 0.0%; p = 0.023) were associated with disease chronicity. At baseline visits, patients evolving into chronic disease presented a significantly increased frequency of hypertension, osteopenia, and morning stiffness (p < 0.001-p = 0.010). A progressive reduction in CDAI and the number of painful joints was observed, consistent with an increase in the percentage of patients with clinical improvement over time, which rose from 34.6% in the baseline visit (V1) to 72.5% in V4. Factors such as female gender, middle age, hypertension, osteopenia, and morning stiffness at the acute phase of the disease are predictors of symptom persistence and progression to chronicity. Early therapeutic intervention with continuous clinical follow-up has proven to decrease disease activity over time, reinforcing the importance of proactive management to prevent the progression of pCHIKV-CIJD. Key Points • Female gender, middle age, hypertension, osteopenia, and morning stiffness predict chronic joint symptoms after Chikungunya infection. • Early treatment and regular follow-up reduce disease activity and improve patient's outcomes over time.

Concrete and mortar production consumes significant natural resources, leading to environmental concerns and sustainability challenges. Sustainable alternatives, such as industrial byproducts, have been explored to replace clinkers and aggregates. Basalt rock powder (BRP) is a promising option due to its physical and chemical properties, including its better particle size distribution and compatibility with cementitious composites, and studies have highlighted its pozzolanic activity and its potential to improve mechanical properties (compressive strength, flexural strength, and durability). Reusing rock dust as a raw material could transform it into a mineral byproduct, benefiting the new material and reducing waste volumes. This article presents a systematic literature review on the use of BRP in construction materials, conducted using the Scopus, ScienceDirect, PubMed, and Web of Science databases and following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) procedures. The search resulted in 787 articles (up to December 2024) and, after the screening process, 17 met the inclusion criteria. From the selected articles, information regarding the utilization of this waste product; its influence on mechanical properties, pozzolanic activity, and durability; and the sustainability associated with its use was compiled. The risk of bias was low as the search was comprehensive, all the papers were peer-reviewed, and all authors reviewed the papers independently. In conclusion, the studies demonstrate the potential of using BRP as a component of cementitious materials, indicating it as a possible innovative solution to the current challenges in the construction industry.

O Diabetes Mellitus Tipo 2 (DM2) associado à obesidade representa um dos maiores desafios para a saúde pública, devido à sua alta prevalência e dificuldade de controle com terapias convencionais. A cirurgia bariátrica tem se destacado como uma alternativa eficaz no manejo do DM2, promovendo não apenas significativa perda de peso, mas também remissão metabólica, através de mecanismos que transcendem a restrição calórica. Esta revisão integrativa teve como objetivo analisar as evidências disponíveis sobre o impacto da cirurgia bariátrica na remissão do DM2. Foram selecionados estudos publicados entre 2015 e 2025, que avaliaram diferentes técnicas cirúrgicas e seus efeitos no controle glicêmico. Os resultados demonstraram que procedimentos como o bypass gástrico e a gastrectomia vertical proporcionam altas taxas de remissão, redução da necessidade de medicamentos e melhora das comorbidades associadas. Contudo, a manutenção desses benefícios depende da adesão a um acompanhamento multidisciplinar e de mudanças sustentáveis no estilo de vida. Conclui-se que a cirurgia bariátrica é uma intervenção segura e eficaz para o controle do DM2, mas requer criteriosa seleção de pacientes e monitoramento contínuo para evitar complicações e garantir a durabilidade dos resultados.

A epilepsia refratária é definida como a persistência de crises epilépticas mesmo após o uso adequado de pelo menos dois fármacos antiepilépticos bem conduzidos. Essa condição acomete cerca de 30% dos pacientes com epilepsia e está associada a significativos prejuízos na qualidade de vida, aumento da morbimortalidade e elevados custos sociais e econômicos. Objetivo: Este estudo teve como objetivo revisar os protocolos atuais e explorar novas perspectivas terapêuticas no manejo da epilepsia refratária. Metodologia: Trata-se de uma revisão narrativa da literatura. Foram consultadas as bases de dados PubMed, Scielo, LILACS e Google Scholar, utilizando os descritores "epilepsia refratária", "tratamento", "canabidiol", "cirurgia da epilepsia", "estimulação do nervo vago" e "novas terapias". Foram incluídos artigos publicados entre 2018 e 2024, disponíveis em português, inglês ou espanhol. Resultados e Discussão: Diversas abordagens emergentes vêm sendo estudadas com resultados promissores. O canabidiol demonstrou eficácia na redução da frequência das crises em casos refratários específicos. A cirurgia da epilepsia, quando indicada, oferece potencial curativo. Técnicas de neuromodulação, como a estimulação do nervo vago e cerebral profunda, também se mostram efetivas. Além disso, dietas cetogênicas, novas drogas e avanços em terapias gênicas e celulares despontam como futuras estratégias. Conclusão: O manejo da epilepsia refratária exige uma abordagem multidisciplinar e individualizada. A constante atualização dos profissionais de saúde e o investimento em terapias inovadoras são fundamentais para melhorar o prognóstico dos pacientes e ampliar o acesso a tratamentos eficazes.