Chemo (France)

Temporal Dominance of Sensations (TDS) and Temporal Check-All-That-Apply (TCATA) make it possible to capture temporal changes in the perception of sensory attributes within a product. However, temporal measurements bring new sources of uncontrolled variability that can make them imprecise, particularly with consumer panels. This article aims to demonstrate the importance of considering this imprecision when interpreting temporal data. First, the levels of imprecision due to non-repeatability or disagreement were assessed. The precision of TDS and TCATA was shown to be low, mainly due to disagreement caused by high heterogeneity in total durations of perception. Then, a new framework of analysis has been introduced. It allowed testing of differences in the median times of selection or unselection of attributes. A new representation of TDS and TCATA data has been proposed to visualize and objectify uncertainty in periods of perception. The conclusions obtained with the new framework were compared to those obtained with the usual analyses based on the evolution of citation rates over time. It was shown that the interpretation of TDS/TCATA curves and difference curves can be tricky without guidelines regarding the minimum size of differences that can be considered significant and interpretable. Finally, it was shown that the temporal resolution of the methods was about 10% of the total duration of the perception. These findings question the ability of TDS and TCATA to capture subtle temporal differences. Therefore, recommendations were made for interpreting temporal data in a way that robust conclusions can be drawn.

A new series of 3-acetyl-1,3,4-oxadiazoline hybrid molecules was designed and synthesized using a condensation between acyclonucleosides and substituted phenylhydrazone. All intermediates and final products were screened against Leishmania donovani, a Protozoan parasite and against three viruses SARS-CoV-2, HCMV and VZV. While no significant activity was observed against the viruses, the intermediate with 6-azatymine as thymine and 5-azathymine-3-acetyl-1,3,4-oxadiazoline hybrid exhibited a significant antileishmanial activity. The later compound was the most promising, exhibiting an IC50 value at 8.98 µM on L. donovani intramacrophage amastigotes and a moderate selectivity index value at 2.4.Graphical Supplementary InformationThe online version contains supplementary material available at 10.1007/s11030-022-10548-9.

Recent advances in moiré superlattices and moiré excitons, such as quantum emission arrays, low-energy flat bands, and Mott insulators, have rapidly attracted attention in the fields of optoelectronics, materials, and energy research. The interlayer twist turns into a degree of freedom that alters the properties of the systems of materials, and the realization of moiré excitons also offers the feasibility of making artificial exciton crystals. Moreover, moiré excitons exhibit many exciting properties under the regulation of various external conditions, including spatial polarisation, alternating dipolar to alternating dipolar moments and gate-dependence to gate voltage dependence; all are pertinent to their applications in nano-photonics and quantum information. But the lag in theoretical development and the low-efficiency of processing technologies significantly limit the potential of moiré superlattice applications. In this review, we systematically summarise and discuss the recent progress in moiré superlattices and moiré excitons, and analyze the current challenges, and put forward relevant recommendations. There is no doubt that further research will lead to breakthroughs in their application and promote reforms and innovations in traditional solid-state physics and materials science.

PCOS represents a chronic disease affecting between 8 -10 % of women during their reproductive life. Concepts were developed that re-define inflammation as being composed of the inflammatory response and active resolution processes, which occur at the same time. Key players are the specialized pro-resolving lipid mediators (SPMs).

High-performance lithium ion batteries are ideal energy storage devices for both grid-scale and large-scale applications. Germanium, possessing a high theoretical capacity, is a promising anode material for lithium ion batteries, but still faces poor cyclability due to huge volume changes during the lithium alloying/dealloying process. Herein, we synthesized an amorphous germanium and zinc chalcogenide (GZC) with a hierarchically porous structure via a solvothermal reaction. As an anode material in a lithium ion battery, the GZC electrode exhibits a high reversible capacity of 747 mA h g−1 after 350 cycles at a current density of 100 mA g−1 and a stable capacity of 370 mA h g−1 after 500 cycles at a current density of 1000 mA g−1 along with 92% capacity retention. All of these outstanding electrochemical properties are attributed to the hierarchically porous structure of the electrode that has a large surface area, fast ion conductivity and superior structural stability, which buffers the volumetric variation during charge/discharge processes and also makes it easier for the electrolyte to soak in, affording more electrochemically active sites.

Isothermal amplification techniques for nucleic acid detection have drawn increasing interest recently due to the simplicity and low-cost of instruments.

Cu/Au/Pt trimetallic nanoparticles (TMNPs) with enhanced catalytic activity and intense plasmonic absorption in the NIR-I biowindow (650-950 nm) were prepared using a fast, gentle and one-pot protocol. Based on these properties and assembly of thiolated-aptamers on Cu/Au/Pt TMNPs, a universal platform was developed for applications in biosensing and theranostics.

Genetically encoded light-up RNA aptamers afford a valuable platform for developing RNA sensors toward live cell imaging. However, quantitative imaging of intracellular RNAs remains a grand challenge. Here we reported a novel genetically encoded RNA sensor strategy using a plasmid that expresses a splittable fusion of the RNA sensor and the GFP mRNA in an individual transcript using a single promoter system. This splittable fusion design enables synchronous co-expression of the RNA sensor with GFP mRNA while alleviates the interference with correct folding of RNA aptamers due to intramolecular hybridization. This single-promoter system is applied to ratiometric imaging of survivin mRNA in tumor cells. The results reveal that the ratiometric images dynamically correlated with survivin mRNA concentrations and allow quantitative imaging of survivin mRNA in different tumor cells. The RNA sensor strategy may provide a new paradigm for developing a robust imaging platform for quantitative mRNA studies in living cells.

A novel enzyme mediated AuNP assembly based colorimetric method for ultrasensitive detection of hepatitis C virus antibody.

Two novel covalent organic frameworks (COFs) bearing Kagome lattices have been fabricated through the condensations of a D2h symmetrical tetraaldehyde and C2 symmetrical aromatic diamines of various lengths.