Chinese University of Hong Kong

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Top subject area publications in last 5 years

Collaboration Analysis

Publications from 2021 to 2026

Latest Publications

Showing 10 of 19,683 papers

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Research Article
10.1016/j.ast.2026.112197

Orbit-Structure-Contact dynamics modeling and simulation for virtual validation of active debris removal by space robots

Oct 01, 2026
Aerospace Science and Technology
Jianfeng Lu + 5 more +5

Research Article
10.1016/j.future.2026.108451

Applying quantum error-correcting codes for fault-tolerant blind quantum cloud computation

Sep 01, 2026
Future Generation Computer Systems
Qiang Zhao + 1 more +1

Research Article
10.1016/j.bioactmat.2026.02.019

Flexible biodegradable wireless battery-free integrated theranostic adhesive patch.

Jul 01, 2026
Bioactive materials
Shuaiyin Liu + 13 more +13

Research Article
10.1016/j.neunet.2026.108676

A knowledge-driven self-supervised learning method for enhancing EEG-based emotion recognition.

Jul 01, 2026
Neural networks : the official journal of the International Neural Network Society
Hanqi Wang + 7 more +7

Research Article
10.1016/j.optlastec.2026.114861

Integrated optical wireless positioning and multi-user communication based on petal-shift keying structured beams

Jun 01, 2026
Optics & Laser Technology
Haoyu Huang + 6 more +6

Research Article
10.1016/j.tourman.2025.105361

Three decades of evolution: Key research trends in Tourism Management

Jun 01, 2026
Tourism Management
Cathy H.c Hsu + 2 more +2

Research Article
10.1016/j.procbio.2026.03.002

Molecular mechanisms of fatty acids influence on bio-imprinted Rhizomucor miehei lipase towards 1,3-dioleoyl-2-palmitoyl glycerol synthesis

Jun 01, 2026
Process Biochemistry
Haotian Ma + 6 more +6

Research Article
10.1016/j.jebdp.2026.102239

EFFECTIVENESS OF DISINFECTION METHODS FOR TOOTHBRUSHES: A SYSTEMATIC REVIEW AND META-ANALYSIS.

Jun 01, 2026
The journal of evidence-based dental practice
Jiachen Li + 8 more +8

Research Article
9
10.1016/j.ecz.2025.100032

Nature-based solutions in coastal urbanization: Addressing environmental and socio-economic challenges

Jun 01, 2026
Earth Critical Zone
Peiheng Yu + 5 more +5

Research Article
10.1016/j.bmcl.2026.130572

Synthesis and characterization of bicyclo[1.1.0]butane amides and 5-methylene-3-azabicyclo[5.1.0]octan-4-ones as covalent modifiers.

Jun 01, 2026
Bioorganic & medicinal chemistry letters
Karis Texidor + 16 more +16

Covalent inhibitors have re-emerged as powerful therapeutic agents, offering the ability to modulate "undruggable" proteins including oncogenic drivers that have eluded traditional drug discovery efforts. Expanding the repertoire of electrophilic moieties remains a critical frontier in covalent drug discovery. Here, we report a Rh(I)-catalyzed cycloisomerization of N-allyl bicyclo[1.1.0]butane amides (BCB amides) to access the 5-methylene-3-azabicyclo[5.1.0]octan-4-one (MABO) scaffold via strain-release reactivity. Both N-allyl BCB amides and MABOs can react with nucleophiles, highlighting their potential as electrophilic moieties for covalent drug design. Kinetic assays against glutathione revealed that selected N-allyl BCB amides and MABOs exhibit half-lives comparable to that of (±)-sotorasib, whose enantiomerically pure form received FDA approval as an anticancer drug. Biological evaluation in human-derived head and neck squamous cell carcinoma (HNSCC) models identified specific BCB amides and MABO compounds capable of modulating cancer cell growth. The toxicity of the compounds was evaluated by flow cytometry in human peripheral blood mononuclear cells (PBMCs) and by monitoring LDH release in the monocytic cell line THP-1, both under basal and activated conditions. Together, these findings suggest that BCB amides and MABOs represent promising classes of electrophilic scaffolds for covalent drug discovery.