Chungbuk National University

Objectives: To clarify the characteristics of Basosquamous cell carcinoma (BSC), this study compares demographic, clinical, therapeutic, histological, and outcome findings of BSCs with those of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Methods: The authors classified various definitions of BSC into three groups: the broadest, modest, and narrowest definitions. This study adopted the narrowest definition (both BCC and SCC features with transition zones in between) due to its wide use, its adoption by the World Health Organization, and the least heterogeneous definition. From 2009 to 2018, 20 consecutive cases of BSC presented in a single institution, along with 130 cases of BCC and 81 cases of SCC. Results: The statistically different parameters of BSC compared to BCC or SCC were age (SCC > BSC, BCC), duration (BSC, BCC > SCC), unclear border (BSC > BCC, SCC), higher NCCN classification (BSC, SCC > BCC), safety margin (SCC > BSC > BCC), operation time (BSC, SCC > BCC), reconstruction (less primary closure in BSC than BCC), microscopic size (BSC, SCC > BCC), perineural invasion (BSC > BCC), free lateral margin (BSC, SCC > BCC), and follow-up period (BSC > BCC, SCC). Regarding outcome, one distant metastasis (6.3%) in BSCs, no aggressive consequences in BCCs, and four local recurrences (11.1%), two lymph node metastases (5.6%), and one distant metastasis (2.7%) in SCCs were observed. Conclusions: In this Asian cohort, BSC has a trend toward higher rates of overall adverse outcomes compared to BCC, although this difference did not reach definitive statistical significance, unlike the findings reported in Caucasian populations. Early detection and appropriate treatment at the individual patient level are warranted to minimize rare but clinically relevant adverse events and reproduce favorable outcomes at the population level. Wide local excision followed by local flaps could be a successful surgical option with an adequate safety margin and double histopathologic intraoperative and postoperative check-up.

The Cover Feature illustrates an electroreductive nickel platform as a rail system, where a central Ni “switch” directs the fate of alkynes. By tuning electrochemical conditions, the same substrate is selectively routed to alkenes through a non-NiH ECEC-type semireduction pathway or to alkanes through NiH formation. More information can be found in the Research Article by I. Choi and co-workers (DOI: 10.1002/cssc.202502632).

In recent times, slicing methods have yielded a successful outcome in generative models for image, sound, and text data, primarily focusing on joint distributional learning. However, we have identified a critical limitation of the slicing approach for tabular data: it struggles to capture marginal distributional patterns, which are significant for effective tabular data synthesis. To tackle this problem, we introduce a new measure of discrepancy, the mixture Cramer–Wold distance. This measure enables us to capture both marginal and joint distributional patterns simultaneously, striking a balance between the two aspects, and we provide theoretical foundations for its application. Leveraging the power of the mixture Cramer–Wold distance, we present CWDAE (Cramer–Wold Distributional AutoEncoder), a generative model that demonstrates notable performance in generating synthetic tabular data. Furthermore, our model offers the flexibility to adjust the level of data privacy to meet specific needs easily.