Concern Worldwide UK

The convergence of (multi-)omics and artificial intelligence is transforming precision medicine by enabling data-driven diagnostics, treatment prediction, and patient stratification. Yet, regulatory frameworks lag behind this innovation. This commentary discusses emerging issues around data integrity, algorithm transparency, validation and real-world evidence integration, highlighting gaps between device and pharmaceutical regulations. Drawing on examples of regulatory-approved AI-enabled (multi-)omics tools in the EU and US, we explore evolving regulatory pathways shaping the clinical adoption of next-generation tools for precision medicine.

Dieses Kapitel erläutert, was die Zwillingstransformation, welche Nachhaltigkeit und Digitalisierung miteinander verbindet, bedeutet. Vor diesem Hintergrund erfolgt eine Einführung in die Ethik der Künstlichen Intelligenz,Ethikder KI die die grundlegenden ethischen Prinzipien, die mit der Entwicklung und Anwendung von KI-Technologien verbunden sind, untersucht und kritisch bewertet. Dem folgt ein Abschnitt über RegulatorikRegulatorik vor allem auf europäischer Ebene, gefolgt von einer Betrachtung der Rolle Verhaltenskodexfreiwilliger Verhaltenskodizes, die als Schlüssel zur ethischen Positionierung von Unternehmen dienen. Diese Kodizes werden auf der Mesoebene eingeführt und bieten Unternehmen eine Möglichkeit, über die gesetzlichen Anforderungen (Makroebene) hinaus Verantwortung zu übernehmen und Vertrauen aufzubauen. Abschließend wird auf der Mikroebene die Bedeutung individueller digitaler Primärtugenden untersucht, die notwendig sind, um die ethische Nutzung von Technologie sicherzustellen und eine nachhaltige digitale Transformation zu fördern. Nutzungethische von TechnologieTransformationnachhaltige digitale

ABSTRACT Although poultry meat production supports the livelihood and provides food security for billions of people worldwide, it is facing substantial challenges. The emergence of broiler breast myopathies (white striping, woody breast, spaghetti meat) at large scale is one of the most significant economic and welfare challenges that menace poultry production sustainability and for which there is currently no effective prevention, due to its unknown aetiologies. Here, by inviting and gathering several experts with diverse, but complementary disciplines, the objective of the present review is to highlight the current progress and knowledge on these myopathies. Five sections are presented, describing in detail the history and geographic occurrence of these breast myopathies, their macroscopic morphologies and microscopic characteristics, their putative aetiologies and causes as well as their underlying molecular mechanisms, and potential strategies and solutions. The is review summarizes both descriptive and functional mechanistic studies, highlights the complexity of these myopathies and the kinship between broiler genome, nutrition, and management, and outlines some of the promising molecular signatures. It aims to offer new fundamental frameworks for future investigations.

In this paper, we consider the issue of evaluating the vibration activity of complex multichannel aggregated hydraulic devices (AD) that combine in their design several simultaneously involved working elements (throttles, spool valves), flow channels of complex geometry, and control elements of various modes. In such conditions, it is extremely important to determine the contribution of the main elements to the resulting vibration characteristic of the device. To perform these works, it is necessary to develop an order and methodology for their implementation. The paper presents the main provisions of the developed methodology and the results of their implementation, including the following sequence of actions: Before installing the AD on the bench, the natural frequencies of free vibrations of the structure and its elements were determined by its free suspension. The results obtained were taken into account in the subsequent analysis. A program for measuring the vibration characteristics of the AD in various hydraulic modes of operation was developed. A map of vibration control points was compiled, determining the characteristics of specific structural elements of the AD design. A form of presentation and analysis of vibration characteristics at measurement points with a temperature distribution of the results over 1/3 octave frequency bands was developed. The planned tests were carried out, the results were analyzed, and the directions of work to improve the design of the AD and its test conditions were determined. The results of applying the above methodology in testing the vibration activity of the experimental AD sample made it possible both to determine the direction of improvement of its design and to optimize the operating modes of the main working bodies.

The purpose of this study is to evaluate the effectiveness of the inhibited Neftyanaya Emulsiya Hlorno-Kalievogo Termostabilizirovannogo - inhibited drilling solution - (NEHKT) drilling solution when drilling unstable rocks in red-colour sediments in a certain range of occurrence at a particular well. The study includes preparation of the solution, laboratory tests to determine the optimal components and their proportions, and conducting controlled experiments during which the solution was used in practice. During these tests, the inhibited NEHKT drilling fluid was used in real drilling conditions to evaluate its effectiveness. Conducting controlled experiments allowed evaluating of its ability to prevent complications during the drilling process and the success of the descent and cementing of the production column. The effectiveness of the inhibited NEHKT drilling solution was confirmed under conditions of drilling unstable rocks in red-coloured sediments in the range of 2000-2600 m at well No. 810 of the Nebitdag area. Drilling was also successfully conducted without complications when using the solution, which confirms its ability to ensure the stability of the drilling process and prevent possible problems associated with unstable rocks. The ability of the inhibited NEHKT solution to maintain its structural and mechanical properties in conditions of high mineralisation, penetrate the interplane space of clays, preventing their hydration and swelling, and bind all the water in the solution into persistent hydrates, which contributes to the stability and safety of the drilling process, is identified. Thus, the results of this study indicate the prospects and effectiveness of the inhibited NEHKT drilling solution in the context of ensuring a safe and stable drilling process for unstable rocks in red-coloured sediments.

The article presents the analysis of Russian journals whose topics are related to the areas of activity of the Scientific Council on Control Theory and Processes at the Department of Energy, Mechanical Engineering, Mechanics and Control Processes of the Russian Academy of Sciences. Results of a survey of the leading Russian scientists in this field of science, including members of the council, helped to form a preliminary list of journals. The characteristics of these journals and their existing ratings are presented.It is noted that the well-known scientometric indicators do not allow one to evaluate the journals’ development pathways directly. A proposed indicator characterizes the average rate of change in a journal’s impact factor over a given time interval. The values of development indicators have been calculated and analyzed according to the Russian Index of Science Citation (RISC) and Scopus databases for the abovementioned journals included in these databases. The development pathways of some individual journals are considered.The article gives conclusions and recommendations that may be useful to the editorial staff – with a view to promoting their publications and to authors – in choosing a journal for publication.

The study of the properties of clay minerals and the creation of innovative drilling fluids based on them are extremely important aspects for improving the processes of extraction of natural resources, reducing operating costs, and increasing the energy efficiency of industrial operations. The purpose of this study was to explore the possibilities of developing a composition of drilling fluids based on the investigation of the properties of clay minerals for drilling and maintenance of wells in the conditions of the Gubadag deposit located in Turkmenistan. Statistical methods, experiments, and analysis were used in the course of the work. The results of the study showed that clay from the Gubadag deposit is characterised by low hydrophilicity and weakened structural stability, which is manifested in limited hydration energy and high filtration permeability. This leads to low viscosity, rheological, and structural-mechanical parameters of natural solutions. It follows from this that Gubadag clay is classified as a low-quality material. The prepared solutions from the above samples on different types of water have volumes in the range of 2-3 m³. However, after treating sea water with caustic soda, sample No. 2 generates more than 4 m³ of solution, significantly different from other samples. This highlights the need for additional research to optimise drilling fluid formulae, since it is important to determine the effect of clay materials on the properties of solutions and develop more adapted formulae that consider the specifics of the material and the conditions of its use in drilling wells. The practical significance of the results obtained lies in a significant improvement in the efficiency of drilling and maintenance of wells in regions with difficult geological conditions, offering new methods for preparing drilling fluids.

Background. The disadvantage of spectrally efficient signals with frequency multiplexing is the occurrence of intersymbol interference, which is further aggravated when these signals propagate in frequency selective channels.
 Aim. The possibility and effectiveness of using neural network approaches for channel equalization and signal detection in communication systems using SEFDM signals has been assessed.
 Methods. A receiver structure for SEFDM systems based on a deep complex-valued convolutional neural network is proposed, which allows recovering bits from the temporal representation of the signal without using the fractional Fourier transform and inverting the cross-correlation matrix between frequency subcarriers. A two-stage network training scheme has been developed. Based on simulation modeling, a comparative analysis of the noise immunity of SEFDM systems was carried out both in a channel with white Gaussian noise and in a channel with Rayleigh fading, using classical and neural network receivers.
 Results. It is shown that there is no loss of noise immunity in channels with additive white Gaussian noise and an increase in noise immunity of the system up to 2 dB in the channel specified by the extended automotive model (3GPP-EVA).
 Conclusion. The effectiveness of using deep neural complex-valued convolutional networks as receivers for spectrally efficient communication systems, as well as their advantage over classical ones, is shown.
 Keywords – SEFDM; deep complex-valued convolutional neural network; turbocoding.

Arun Kalyan Baksi and colleagues propose a model of care delivery, termed local care boards, integrating all health and social care services in a locality, with the aim of addressing some of the fundamental problems faced by the NHS.