Cosmos Corporation (United States)

Unpleasant odors in restrooms in railway stations and on trains are one of the objects of many complaints from railway customers. Therefore, countermeasures to reduce these unpleasant odors are required. In railway station restrooms, we are investigating the sources of ammonia, one of the main compounds responsible for unpleasant odors in public restrooms. To conduct this investigation, we developed a prototype of a portable, highly sensitive ammonia measuring instrument. We used this instrument to search for sources of ammonia in men's railway station restrooms and confirmed the difference in concentration of ammonia depending on cleaning methods and seasons. In addition, we verified the effectiveness of countermeasures implemented by cleaning companies to reduce unpleasant odors.

Oyster aquaculture is essential for ensuring a sustainable food source. Despite stringent controls, cases of oyster-related illnesses linked to pathogenic Vibrio parahaemolyticus (Vp) and Vibrio vulnificus (Vv) persist. This study investigated the impact of aquaculture practices on the oyster microbiome and pathogen levels, focusing on two common systems: on-bottom and floating cages. From June to November 2019, monthly samples were collected from the Chesapeake Bay, including oysters and water from each aquaculture system. Oyster samples included both fresh and temperature-abused oysters. The study utilized the most probable number and real-time PCR (MPN-qPCR) method to quantify total and pathogenic Vp and Vv in water and oyster samples. DNA was extracted from oyster homogenates and filtered water samples for shotgun metagenomic sequencing. The results revealed significant impacts of aquaculture practices on the diversity of the oyster microbiome, particularly affecting the distribution of phages, antibiotic resistance, and virulence factor genes. Shotgun metagenomic sequencing consistently showed higher genetic representation of Vibrio in floating cages for both fresh and temperature-abused oyster samples. MPN-qPCR results differed between practices, showing higher Vibrio levels in bottom cages for fresh oysters and higher levels in floating cages under temperature abuse. These discrepancies are likely explained by the stable conditions in bottom cages, the effects of temperature abuse, and the growth bias inherent to the MPN method. These results underscore the need for a holistic, time-sensitive approach, taking into account microbial states and the dynamic aspects of the oyster environment to understand the complex relationship between aquaculture practices and the oyster microbiome.IMPORTANCEThis study holds great importance for food safety, antibiotic resistance surveillance, aquaculture management, and environmental health. Unraveling the population dynamics of microbial communities in oysters and their responses to different aquaculture practices enhances our ability to ensure safer seafood, monitor antibiotic resistance, optimize aquaculture methods, and mitigate potential public health challenges. Moreover, it demonstrates the applicability of advanced metagenomic tools for future research. Furthermore, this research addresses critical aspects of food safety, food security, public health, and sustainable aquaculture practices, making it highly relevant in today's context.

Background: Repetitive transcranial magnetic stimulation (rTMS) is an established neuromodulatory method, yet its multiscale neurophysiological effects in autism spectrum disorder (ASD) remain insufficiently characterized. Recent EEG analytic advances—such as spectral parameterization, long-range temporal correlation (LRTC) assessment, and connectivity modeling—enable quantitative evaluation of excitation–inhibition (E/I) balance and network organization. Objective: This study aimed to examine whether an eight-session, EEG-guided mixed-frequency rTMS protocol—combining inhibitory 1 Hz and excitatory 10 Hz trains individualized to quantitative EEG (qEEG) abnormalities—produces measurable changes in spectral dynamics, temporal correlations, and functional connectivity in a pediatric ASD case. Methods: An 11-year-old right-handed female with ASD (DSM-5-TR, ADOS-2) underwent resting-state EEG one week before and four months after intervention. Preprocessing used a validated automated pipeline, followed by spectral parameterization (FOOOF), detrended fluctuation analysis (DFA), and connectivity analyses (phase-lag index and Granger causality) in MATLAB (2023b). No inferential statistics were applied due to the single-case design. The study was conducted at Cosmos Healthcare (London, UK) with in-kind institutional support and approved by the Atlantic International University IRB (AIU-IRB-22-101). Results: Post-rTMS EEG showed (i) increased delta and reduced theta/alpha/beta power over central regions; (ii) steeper aperiodic slope and higher offset, maximal at Cz, suggesting increased inhibitory tone; (iii) reduced Hurst exponents (1–10 Hz) at Fz, Cz, and Pz, indicating decreased long-range temporal correlations; (iv) reorganization of hubs away from midline with marked Cz decoupling; and (v) strengthened parietal-to-central directional connectivity (Pz→Cz) with reduced Cz→Pz influence. Conclusions: Mixed-frequency, EEG-guided rTMS produced convergent changes across spectral, aperiodic, temporal, and connectivity measures consistent with modulation of cortical E/I balance and network organization. Findings are preliminary and hypothesis-generating. The study was supported by in-kind resources from Cosmos Healthcare, whose authors participated as investigators but had no influence on analysis or interpretation. Controlled trials are warranted to validate these exploratory results.

This study analyzes the challenges facing the Competitiveness, Science, Technology, and Innovation System (SCSTI) in the Department of Amazonas, Colombia. Drawing on a review of specialized literature and diverse secondary sources, it identifies key factors underlying these challenges, as well as their most visible consequences: low levels of competitiveness and an underdeveloped scientific and technological output. In response, the study proposes a comprehensive strategy focused on implementing coordinated agendas, strengthening local capacities, and promoting mechanisms that facilitate knowledge transfer and application. These measures aim to stimulate increased investment in Scientific, Technological, and Innovative Activities (STIAs) and to improve the management of projects financed through royalty funds, thereby contributing to the region's sustainable development. Ultimately, this work seeks to inform the design of public policy and to serve as a foundation for collaboration among key stakeholders in consolidating the SCSTI ecosystem in the Colombian Amazon.

Objective Various bacterial Bacillaceae and Bacillus strains have demonstrated health benefits, but less is known about probiotic characteristics of strains of Bacillus velezensis. In this randomized, double-blind, placebo-controlled clinical trial, we investigated the safety and efficacy of B. velezensis BV379 supplementation for 8 weeks (2 × 109 colony-forming units (CFU)/day). Methods During the baseline and final weeks, GI symptoms were recorded daily using the 8-item Gastrointestinal Tolerance Questionnaire (GITQ). The primary outcome was the proportion of participants showing an improvement from baseline to week 8 in the 7-day, 3-item composite score for abdominal distention/bloating, burping, and gas/flatulence. Plasma chemistry, hematology, intestinal permeability, and fecal metagenomes were also investigated. Results Eighty participants (54% female; age: 50.3 ± 10.1 years) were randomized to BV379 (n = 39) or placebo (n = 41). At end of study, no significant difference was observed in the percentage of participants with improvement in the 3-item composite GITQ score (BV379: 36.1%; placebo: 28.2%; p = 0.46). Analysis of individual GI symptoms showed that more participants experienced improvement in abdominal distention/bloating with BV379 compared to placebo (38.9% vs 17.9%; p = 0.044). There were no clinically meaningful changes in plasma chemistry, hematology, or intestinal permeability between groups. Fecal metagenomic analyses showed no overall shifts in microbial composition between groups. In addition to B. velezensis, a few commensal species such as Lacticasei bacillus casei were significantly enriched in the BV379 group. Conclusion Despite not significantly improving the composite GITQ score of distention/bloating, burping, and gas/flatulence, BV379 supplementation was a well-tolerated approach to specifically lower abdominal bloating.

In this paper, we investigate the effects of the radion on processes. The numerical results show that the cross-section with unparticle effects should be about 105 time larger than the one with photon effects. This could have important implications for dark matter searches.

Over the last few years, with the advent of virtual and augmented reality, an enormous amount of research has been focused on modeling, tracking and reconstructing human hands. Given their power to express human behavior, hands have been a very important, but challenging component of the human body. Currently, most of the state-of-the-art reconstruction and pose estimation methods rely on the low polygon MANO model. Apart from its low polygon count, MANO model was trained with only 31 adult subjects, which not only limits its expressive power but also imposes unnecessary shape reconstruction constraints on pose estimation methods. Moreover, hand appearance remains almost unexplored and neglected from the majority of hand reconstruction methods. In this work, we propose “Handy”, a large-scale model of the human hand, modeling both shape and appearance composed of over 1200 subjects which we make publicly available for the benefit of the research community. In contrast to current models, our proposed hand model was trained on a dataset with large diversity in age, gender, and ethnicity, which tackles the limitations of MANO and accurately reconstructs out-of-distribution samples. In order to create a high quality texture model, we trained a powerful GAN, which preserves high frequency details and is able to generate high resolution hand textures. To showcase the capabilities of the proposed model, we built a synthetic dataset of textured hands and trained a hand pose estimation network to reconstruct both the shape and appearance from single images. As it is demonstrated in an extensive series of quantitative as well as qualitative experiments, our model proves to be robust against the state-of-the-art and realistically captures the 3D hand shape and pose along with a high frequency detailed texture even in adverse “in-the-wild” conditions.

As invasive grasses encroach upon native ecosystems, they have the potential to transform intact California coastal sage scrub (CSS) into non-native grasslands. This occurs—in part—due to legacy effects: changes in soil microbial composition elicited by grass invasions with long-term impacts on soil and native vegetation. Along with direct effects on CSS vegetation, legacy effects may alter microbial communities which may in turn impact native plant growth. To tease apart these factors, we monitored growth in three CSS species inoculated with either uninvaded soil or sterilized uninvaded soil that were subsequently planted into a site characterized by observed microbial legacy effects. Our findings indicate native plant growth can be explained by changes in soil microorganisms. Specifically, native Artemisia californica and Baccharis pilularis grew larger in plots with unsterilized uninvaded soil inoculum, which contained a larger abundance of Gemmatimonadetes and Glomus, compared to the sterilized soil inoculum plots. Therefore, microbial augmentation may not only improve restoration in post-invasive sites but long-term changes in soil microbial communities may be linked to native plant growth. Furthermore, adding uninvaded soil replete with native microbes has the potential to support restoration of invaded sites by promoting native plant survival and establishment in these restored ecosystems.