DE Technologies (United States)

In this paper, we explore new advancements in the use of the third-order edge-based Euler solver with implicit edge-based gradient method for anisotropic metric-based mesh adaptations. The effect of boundary treatment, namely the accuracy of geometrical normals in a slip boundary condition is analyzed. Inaccurate normals can lead not only to accuracy order degradation but also to non-physical artifacts. The use of stencil and edge limiters is considered for shock-dominated flows. Three two-dimensional test cases are considered: a subsonic flow over a smooth bump, a transonic flow and a supersonic flow past the NACA0012 airfoil.

Abstract Introduction Key elements in the management of prediabetes include the treatment of obesity and the appropriate management of dyslipidaemia and hypertension. Tirzepatide (TZP) is a once weekly GIP/GLP-1 receptor agonist approved for the treatment of obesity. In the SURMOUNT-1 3-year trial, participants with obesity and prediabetes treated with TZP achieved a mean weight reduction of up to 22.9%, which was accompanied by improvements in cardiometabolic risk factors and 94.5% had reverted to normoglycemia at week 176. Purpose The objective of this post hoc analysis was to evaluate the proportion of participants who met the combined clinically relevant goal of weight reduction >5%, systolic blood pressure (SBP) reduction >5 mmHg and non-HDL cholesterol reduction >10% from baseline to Week 176 in SURMOUNT-1 3-year trial. Methods Post hoc analyses included 568 participants with obesity and prediabetes who completed treatment with TZP (n=454) or placebo (n=114) at Week 176 and had measures for all three outcomes of weight, blood pressure and lipids or had any of the three measurements not meeting the threshold. Comparison of baseline characteristics was based on ANOVA model for continuous data and on Chi-square test for categorical data. Shifts in HbA1c (<5.7% and ≥5.7%), BMI (≤27 and >27 kg/m²) and waist to height ratio (WHtR) categories (<0.53 and ≥0. 53) from baseline to Week 176 were also calculated for those who met the combined clinical goals. Results A total of 145 (25.5%) participants met the combined goal at Week 176. Participants meeting vs. not meeting the combined goal had higher mean SBP (130.0 vs. 124.4 mmHg), total cholesterol (203.6 vs. 186.1 mg/dL), non-HDL cholesterol (155.4 vs. 138.2 mg/dL), LDL cholesterol (123.0 vs, 108.7 mg/dL), and triglycerides (175.2 vs. 148.8 mg/dL) at baseline. Significantly more TZP-treated participants (n=139, 30.6%) met the combined goal vs. placebo participants (n=6, 5.3%), p<0.0001. Moreover, 94.2% (n=131) of TZP participants who met the combined goal also had an HbA1c <5.7% (Figure 1), while 41.0% (n=57) had a BMI ≤27 kg/m² and 28.8% (n=40) had a WHtR <0.53 (Figure 2). Of the six placebo participants who met the combined goal, all also had HbA1c < 5.7%, while 1 had a BMI ≤27 kg/m² and 1 had a WHtR of <0.53. Conclusion In this post hoc analysis, treatment with TZP in participants with obesity and prediabetes was associated with significantly more participants achieving a combined clinical goal of weight reduction >5%, SBP reduction >5 mmHg and non-HDL cholesterol reduction >10% compared to placebo. Furthermore, the majority of TZP participants meeting the combined goal also achieved normoglycemia as defined by HbA1c <5.7%, more than 1 in 3 participants met the BMI goal, and 1 in 4 participants met the WHtR goal suggesting a reduction in central adiposity. Outcomes trials are ongoing to further evaluate the cardiometabolic impact of tirzepatide.

The present exploratory study sought to identify the attitudes towards reading for pleasure of a group of fourth year English as a Foreign Language (EFL) majors after taking mandatory literature courses. A total of 45 students from the School of Modern Languages at a public university in San José, Costa Rica participated in this investigation. In order to elicit the participants’ attitudes and motivations both before and after entering the university, an online survey was administered. The results of the survey showed that after entering the university almost half of the participants kept good reading habits, apart from the mandatory readings. Main findings also reveal that the main pre-university reading motivators suffered a change after entering the university. Although personal enjoyment and relaxation were maintained, motivators related to the general improvement of language skills obtained a higher relevance for the students. The survey answers also suggested the literary works read in class play an important role in the students’ voluntary reading practices. Practical implications are discussed.

Abstract BackgroundFrontotemporal degeneration (FTD) is an umbrella term encompassing a range of rare neurodegenerative disorders that cause progressive decline or changes in cognition, language, behavior, and personality. The FTD Insights Survey was created with the aim of gathering information on the lived experience of FTD. Here we present a subset of survey data chronicling the diagnostic journey, symptoms experienced, and the impact of FTD on distress, quality of life, and independence, in the mild to moderate stages of the disease course.MethodIn total, 1,796 individuals completed the survey. Persons reported as severe to profoundly impaired due to FTD, as well as past caregivers, were excluded for this analysis. The resulting cohort included 219 individuals diagnosed with FTD and 437 current care partners, representing a range of FTD diagnoses (n = 395 behavioral variant frontotemporal dementia or Pick’s disease; n = 155 primary progressive aphasia; n = 61 progressive supranuclear palsy or corticobasal syndrome; n = 13 FTD with amyotrophic lateral sclerosis; n = 32 unknown).ResultAround half of survey respondents saw three or more doctors before an FTD diagnosis was given, and a range of prior diagnoses, including primary psychiatric disorders, Parkinson’s disease, or Alzheimer’s disease, were noted. Most frequently endorsed symptoms tended to be consistent with clinical characteristics of the specific diagnosis, though there was significant variability in symptoms reported within diagnostic categories as well as considerable overlap in symptoms between diagnostic categories. Cognitive and language symptoms of FTD were generally most distressing to the person diagnosed, and a loss of independence was highly endorsed as affecting quality of life. The distinct perspectives of diagnosed persons and care partners regarding disease impact differed notably for bvFTD/Pick’s disease. Participating independently in activities, within the home, outside the home, and with other people, were reported as challenging for people living with FTD, underscoring the significant disruption to daily living even at the mild and moderate stages of disease.ConclusionOverall, by heeding the perspectives of those living with FTD, we can begin to design more meaningful research studies, provide better care, and develop new therapies that improve quality of life

Os provérbios são um tipo especial de unidades linguísticas que tem sido amplamente ignorado pela comunidade de Processamento de Linguagem Natural (PLN), apesar de levantarem desafios interessantes para o processamento. Este artigo apresenta o procedimento de integração do Mínimo Paremiológico do Português no sistema STRING e a distribuição desses provérbios mais usuais em três corpora distintos do português (europeu).

I - La vie privée du salarié L’impact des technologies sur la vie professionnelle des salariés suscite un intérêt de plus en plus vif. Les progrès technologiques influencent la façon dont nous travaillons de plusieurs façons, depuis l’exécution des tâches (façonnées par les possibilités d’automatisation et de numérisation), jusqu’aux moyens dont disposent les employeurs pour surveiller, contrôler et évaluer le travail, mais aussi, de plus en plus, les heures et les lieux de travail. Les avanc...

We introduce the Variational Quantum Unsampling (VQU) protocol, a nonlinear quantum neural network approach for verification and inference of near-term quantum circuits outputs. We experimentally demonstrate this protocol on a quantum photonic processor.

Cet article présente une méthode de visualisation d'une pile temporelle d'images SAR, appelée REACTIV, qui permet de faire ressortir en couleur les zones ayant subi des changements sur la période de temps observée. Cette méthode a été testée à grande échelle grâce à la plateforme Google Earth Engine. Elle est basée sur l'espace de visualisation HSV et n'exploite que des estimations dans le domaine temporel, sans aucune estimation spatiale. La saturation des couleurs est codée par le coefficient de variation temporel, dont plusieurs propriétés statistiques sont explicitées. Les limites de l'utilisation de la plateforme Google Earth Engine sont évaluées, et plusieurs cas d'applications sont proposés : agriculture, dynamique urbaine, trafic maritime.

Dans une première partie, on s’interroge sur le rôle social que jouent les booktubeuses ? Sont-elles des éducatrices, des prescriptrices ? Des créatrices de normes ? Des défricheuses ? Des publicitaires ? Pour mieux comprendre les différents rôles des booktubeurs, on examine les interactions qu’ils entretiennent avec leurs spectateurs, notamment dans les échanges de commentaires qui accompagnent la diffusion des vidéos. Quel type de contrat de communication se met en place entre booktubeuse et abonnées ? Que recherchent les utilisateurs de ces sites ? Dans une seconde partie, à partir des expériences d’enseignants ayant intégré le booktubing en classe, on se questionnera sur les modalités d’intégration pédagogique et les apports possibles de cette pratique pour les apprentissages des élèves.