Dayeh University

The main objectives of present study were to find out relationship among mindfulness, self-compassion and perfectionism among doctors as well as demographics differences such as age, gender, and education on these variables. Three instruments; The Mindful Attention Awareness Scale (MAAS) (Brown& Ryan, 2003). Self-compassion Scale (Neff, 2003) and The Big Three Perfectionism Scale– Short Form (BTPS-SF) were administered on a conveniently selected sample (N=400) doctors along with demographic sheet and informed consent form. Results revealed that mindfulness has positively correlated with self-compassion and, and negatively correlated with perfectionism. Whereas mindfulness has non-significant negative relationship with perfectionism through correlation’s t-test analysis revealed that mean scores of mindfulness and perfectionism are high among males and mean scores of self-compassions are high among females. The analysis revealed that mean scores of mindfulness self-compassion and perfectionism are high in MBBS students than FCPS.

Acute respiratory distress syndrome (ARDS) is a life-threatening form of non-cardiogenic respiratory failure that can occur after severe systemic or traumatic insults. We report a rare case of ARDS in a 17-year-old female who sustained a burst fracture at the second lumbar vertebra and bilateral calcaneal fractures after jumping from a height of six meters. She underwent uneventful spinal decompression and instrumentation six hours post-injury, with stable hemodynamics and balanced fluid administration. Initial chest CT showed no lung abnormalities. On postoperative day 2, she developed respiratory distress preceded by a metallic, blood-like taste during breathing. Follow-up CT revealed new bilateral diffuse lung consolidations. Bronchoscopy showed diffuse pulmonary hemorrhage without active bleeding, suggesting lung contusion. Echocardiography excluded cardiac causes, and extensive microbiological testing, including bronchoalveolar lavage and viral panels, yielded no infectious pathogens. Although broad-spectrum antibiotics were used in response to perioperative fever and elevated inflammatory level, no definitive infection was identified, and inflammatory markers normalized with ventilatory support. This case illustrates a potential underrecognized mechanism of ARDS: pulmonary contusion from high-energy vertical deceleration in the absence of external chest trauma. To our knowledge, no prior literature has reported ARDS following spinal fractures due to vertical falls without chest wall injury. We propose that sudden deceleration during impact can transmit force through the thoracic cage, causing occult microvascular lung injury. Early recognition and close respiratory monitoring are essential in similar trauma scenarios, even when initial imaging is unremarkable.

Introduction: First aid is multifaceted, with one scenario involving mass casualty incidents where multiple patients are injured simultaneously. In such situations, triage must first be conducted, followed by the allocation of appropriate medical resources according to the severity of injuries and the available resources. However, emergency care education in Taiwan rarely addresses this topic, often focusing solely on one-on-one scenarios, leading to a disconnect between education and real-world practice. This study surveys perceptions of mass casualty incidents to explore the importance of community people learning to triage, and then provides scientific suggestions on the design of resilience education for Taiwanese people to jointly build a resilient urban and rural area. Methods: According to the medical treatment process of injured and injured patients, it can be divided into three stages: first aid/first response, ambulance transfer, and medical treatment in the hospital. Therefore, this study focuses on “Community people”, “Civilian rescuer”, “Emergency medical practitioners (including fire department)”, and “Hospital medical staff” are the research objects for which questionnaires are distributed. Then use Standard deviation, One-way ANOVA, Scheffe’s method/Tukey’s range test to analyze and obtain key information. Results: The study found that all four groups agreed that courses on “first aid education under 39 hours” and “disaster preparedness education” should include triage training. Additionally, the study found that hospital-based medical personnel and emergency medical practitioners believe that community members with basic first aid training, volunteers of disaster response teams, and community leaders should learn triage, rather than requiring everyone to learn it. Conclusion: This study suggests that triage training should be included as an extension/supplementary course in disaster resilience education or as part of continuing/in-service education. Give priority to those who already have first aid knowledge and disaster prevention teaming skills to improve their survival rate and resilience in emergencies.

Oral squamous cell carcinoma (OSCC) has a nearly 50% global mortality. Physalin A (PA) shows anti-cancer activities, but its role in metastasis remains unclear in OSCC cells. This study intended to determine whether PA inhibits OSCC cell migration and invasion and to clarify the underlying mechanisms. HSC-3 OSCC cells were analyzed using wound-healing, migration, and invasion assays. Atomic force microscopy (AFM) was used to assess morphological changes. Western blotting examined E-cadherin (E-cad), matrix metalloproteinases (MMPs), and urokinase plasminogen activator (uPA). A RasV12/scrib-/- Drosophila model evaluated in vivo tumor suppression. PA significantly reduced wound closure, migration, and invasion in HSC-3 cells. AFM showed decreased cancer-related morphological alterations. PA increased E-cadherin and reduced MMPs and uPA. PA also inhibited growth factor receptor-bound protein 2 (Grb2)/Ras and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/nuclear factor-kappa B (NF-kB) signaling. In vivo, PA suppressed tumor formation and metastasis in RasV12/scrib-/- genotype Drosophila. PA attenuates HSC-3 OSCC cell migration and invasion by regulating Grb2/Ras, PI3K/Akt/NF-kB, and MMP/uPA pathways, suggesting its potential as an anti-metastatic agent for OSCC.

Chemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating side effect of taxane chemotherapy in breast cancer individuals, often leading to functional impairment and reduced quality of life (QOL). This study evaluated the effectiveness of a hand-foot exercise intervention in reducing CIPN severity and improving QOL. This randomized controlled trial included 74 breast cancer individuals undergoing taxane chemotherapy, who were randomly assigned to an exercise (n = 36) or a control group (n = 38). The exercise group performed a structured hand-foot exercise program, while the control group received standard care. CIPN severity was assessed using the Total Neuropathy Score-Clinical version (TNSc) and Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (NTX) scores, while QOL was measured with the Functional Assessment of Cancer Therapy-General (FACT-G). Assessments were conducted at four time points: post-diagnosis, after the first taxane session, midway through treatment, and within 1month of completion. Data analysis included t-tests, chi-squared tests, and generalized estimating equations. Significant time effects were observed for both subjective and objective CIPN symptoms, with the highest increases at the completion of taxane chemotherapy. However, no significant group effects were found for CIPN severity. QOL remained stable, with no significant time or group effects. CONCLUSIONAND CLINICAL IMPLICATIONS: CIPN symptoms worsened over time, peaking at the end of chemotherapy, while the hand-foot exercise intervention had no significant impact on CIPN severity or QOL. Although the intervention did not yield significant benefits, its feasibility suggests potential for future modifications. Early, personalized, and multimodal interventions may be necessary to mitigate CIPN progression and improve patient outcomes. NCT05641571 (Date of registration: December 7, 2022).

BackgroundCordyceps militaris (CM) is noted for its anti-inflammatory properties and potential efficacy in treating allergic diseases. This research aimed to investigate the anti-inflammatory effect of ethanolic and aqueous extracts from laboratory-cultivated specific Cordyceps militaris on Per a 2-induced keratinocytes and macrophages.MethodsThe effects of aqueous and ethanolic extracts were evaluated in Per a 2-stimulated HaCaT and RAW264.7 cell models. This study encompassed cytotoxicity assays, quantitative real-time PCR, nitric oxide inhibitory assays, Western blot analysis, and cytokine assays.ResultsThe ethanolic and aqueous extracts significantly reduced the Per a 2-induced mRNA levels of IL-8, GM-CSF, and CCL-20 in a dose-dependent manner in HaCaT cells, and the optimal doses of extracts were 20 and 125 µg/mL, respectively. The ethanolic extracts of CM significantly inhibited production of iNOS and NO and downregulated COX-2 in Per a 2-induced RAW264.7 cells. Furthermore, the ethanolic extracts of CM also significantly attenuated secretion of IL-13, IL-2, TNF-α, IL-6, G-CSF, and GM-CSF in a dose-dependent manner in Per a 2-stimulated RAW264.7 cells. High-performance liquid chromatography analyses revealed that the concentrations of cordycepin, adenosine, ergosterol, adenine, uridine, and uracil in the ethanolic extracts of CM were 3.87, 61.24, 44.76, 39.40, 26.68, and 4.66 mg/mL, respectively. The ethanolic extracts of CM, which contain enriched quantities of these compounds, is more effective in terms of anti-inflammation than aqueous extracts of CM.ConclusionsThese important findings reported herein suggest that ethanolic extracts of CM could be further developed as a potential herbal remedy for aeroallergen-induced skin inflammation.Trial registrationNot applicable. This study utilizes HaCaT and RAW264.7 cell culture, not human participants.Supplementary InformationThe online version contains supplementary material available at 10.1186/s12906-025-05132-1.