Dhanvantari Ayurveda College Hospital and Research Centre

Introduction: Myopic astigmatism is a refractive error that combines myopia and astigmatism. Nethra is considered the best among the Pancha Jnanendriyas. In Ayurveda, there are many Shamanaaushadi and Kriyakalpas mentioned for Netra Rogas. Netra Kriyakalpas include Seka, Ashchothana, Anjana, Pindi, Vidalaka, Tarpana & Putapaka. Anjana is the application of medicinal paste over the eyes. Materials & Methods: A fully conscious female patient aged 26 years visited Shalakya Tantra OPD, Alvas Ayurveda Medical College, Moodbidre, with complaints of defective distant vision in both eyes for 7 years. The patient was managed with Nayana Sukha Varti Anjana for 1 month, and follow-up was taken after 1 month. Results: Subject got significant improvement in visual acuity in both eyes. Conclusion: This case highlights the potential of Ayurvedic ophthalmic interventions, specifically Anjana Karma with Nayana Sukha Varti, as supportive therapy in managing myopic astigmatism

Chalcones are a subclass of flavonoids characterized by the presence of an α, β-unsaturated carbonyl system, and they have emerged as important scaffolds in medicinal chemistry because of their structural simplicity, ease of synthesis, and wide spectrum of pharmacological activities. They occur abundantly in nature and are reported to exhibit antioxidant, anti-inflammatory, antimicrobial, and particularly anticancer effects, making them attractive leads for therapeutic development. This review specifically highlights the most recent advances in chalcone-based anticancer research, with a focus on the structural features directly linked to enhanced cytotoxicity activity. Naturally occurring chalcones and their general pharmacological significance are briefly summarized to provide fundamental context. Classical methods, such as the Claisen-Schmidt condensation, remain the most widely used due to their simplicity and high yields, while modern catalytic, solvent-free, and green methodologies have expanded the diversity and efficiency of chalcone libraries. In parallel, structure-activity relationship (SAR) analyses are highlighted to illustrate how substituent effects, heterocyclic incorporation, and linker modifications influence activity profiles. Selected studies are discussed to demonstrate the relationship between structural design and cytotoxic responses across different cancer models. In the selected studies, aim to demonstrate how structural modifications can modulate cellular interactions, enhance therapeutic efficacy, and impact treatment outcomes across various cancer models. By integrating advances in synthesis with biological evaluation, this review emphasizes the versatility of chalcones and provides an updated framework for guiding rational design. The collective evidence underscores their promise as adaptable scaffolds for the development of next-generation anticancer agents.

Introduction: “VEDA” derived from root ‘Vid’ meaning is ‘to Know’ or ‘Knowledge’. It can be considered as Ultimate science. The literatures derived after Veda are having impact of it. In the similar way the science and its branches are also having the impact of Veda. The ever-dynamic Science is originated from Latin verb ‘Scientia’ meaning is ‘to know’. For further in-depth study the science is subdivided into Physics, Chemistry and Biology. Physics is a branch of Science, it means Nature. In Physics all the concepts are in terms of theories or laws. Mechanic branch of Physics deals with the motion of an object with or without the reference of force, i.e. Newtons laws of motion and the Law of gravitation is concerned with motion(or equilibrium)of particles. These Law can be substantiated with Guna Siddhanta. Among Gunas Sthira(Stable), Chala(Moving), Guru(Heavy), Laghu(Light) and Samskara Gunas(Restoration-qualities) are having the similar properties and functions explained in the Newtons law of Motion. Aims & Objectives : To understand the application of Laws of motion with respect to Gurvadi Guna. Materials & Methods: Literary study has been done by Classical texts of Ayurveda, Tarka Sanghraha, Padartha Vijnana Books and 11th NCERT text book of Physics. Discussion: The concepts of Sthira, Chala Guna compared with Sthira Dosha Chalana by Vata Dosha(1st law of motion),Concept of Anupana(Adjuvant) & Akta Lavana Taila(Salt-mixed-oil) application compared to 2nd law of motion and Guru-Laghu Guna(Nidana Sevena) respective changes in the body compared with 3rd law of motion. Results: A brief review of literature was done and found that Newtons Laws of motion is much similar to the Guna Siddhanta. Conclusion : Laws of Motion can be understood through Guna Siddhanta.

Inflammation is a vital biological response to injury and infection, but its persistence beyond resolution stages contributes to a range of chronic diseases, including arthritis, asthma and autoimmune disorders. The nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κΒ) pathway has emerged as a central mediator in sustaining inflammatory cascades through Pro-inflammatory cytokines, chemokines, and adhesion molecules undergo transcriptional regulation. Although conventional anti-inflammatory drugs may offer short-term relief, their long-term use is frequently limited by serious side effects and inadequate targeting of the root causes. In recent years, medicinal plants have gained attention for their potential to manage inflammation in a safer and more holistic way. This narrative review focuses on five such plants- Eclipta alba, Zingiber officinalis, Asparagus racemosus, Phyllanthus emblica and Justica adhatoda- all of which have shown notable analgesic and anti-inflammatory properties. These herbs act through various mechanisms, including suppression of pro-inflammatory cytokines, inhibition of oxidative stress and modulation of NF-κΒ pathway. Beyond these, the review also highlights other herbal agents known for influencing inflammatory responses through NF-κΒ inhibition. The article further discusses the pathogenesis of chronic inflammatory diseases, the biological role of NF-κB, and the limitations of existing treatment options. Together, this review emphasizes the growing relevance of plant-based therapies as effective and safer alternatives for inflammation-related disorders, especially those involving NF-κΒ dysregulation.

Lumbar Disc Disorders (LDDs) are significant cause of disability worldwide with a high prevalence among individuals engaged in sedentary or physically demanding occupations. Among these, Lumbar Disc Herniation (LDH) is closely related to Gridhrasi, a condition described in Ayurveda with symptoms resembling sciatica. Gridhrasi is primarily associated with aggravated Vata Dosha, leading to radiating pain, stiffness, and neurological deficits. The findings of the current study shows that the prevalence of having disc degeneration (either HN, AF or ND) in the age group 15-30 in asymptomatic individuals of Indian ethnicity was 56%. Ayurveda offers a comprehensive approach to managing LDD with Basti (medicated enema) being a key therapeutic intervention. Basti, especially Kati Basti, Anuvasana Basti, and Kashaya Basti, helps pacify aggravated Vata, reduce inflammation, & promote nerve regeneration. This paper explores the role of Basti in the management of Lumbar Disc Disorders with special reference to Gridhrasi, examining its efficacy through classical texts and contemporary research. Integrating Ayurvedic treatments like Basti with modern rehabilitative strategies may offer a holistic and sustainable solution for LDD patients. The pharmacological properties of key Basti yoga’s such as Erandamooladi, Niruha Basti, Dhanwantaram Mrudhupaka, Sahacharaadi Mrudhupaka, Vaitharana Basti, Dashamooladi Basti, Ksheerabala, etc., were analysed for their neuroprotective and anti-inflammatory effects. Clinical evidence supports the efficacy of therapies like Karma Basti and Yoga Basti in reducing pain and inflammation, improving nerve conduction, stabilizing spinal structure, regenerating nerves. Basti therapy serves as safe and effective intervention, offers potential alternative or adjunct to conventional treatments with long term effect.

The saying from Charaka Samhita, a person with no progeny is considered as a tree without any branches holds true even in today’s fast- growing world. Due to various causes, there is trouble in conceiving a healthy progeny. As per Ayurveda texts, Vandhyatva refers to inability to conceive alive and healthy offspring. This study aimed to identify the etiological factors of Stree Vandhyatva as described in classical Ayurvedic texts and to understand the classification told in Samhita. This study involve a review of primary classical textual classical sources such as Charak Samhita , Sushruta Samhita, Bhela Samhita , Harita Samhita and Kashyapa Samhita. Mainly , the Hetu related to the Garbha Sambhava Samagri that is – Rutu , Kshetra , Ambu and beej were reviewed. From the analysis of the text , it was observed that the Shastra tells a diverse range of Hetu for Stree Vandhyatva . This study provided strong foundation to understand the Ayurvedeeya point of view towards StreeVandhyatva.

The word Vrana refers to that “vraṇa gātravicūrṇanē, vraṇayatīti vraṇaḥ” destruction or damage of the tissue of body part is termed as Vrana. It is produced commonly as a complication of Abhighata (Injury) and Vikriti of Dosha, Dushyas, and it causes long term suffering to the patient. Dushtavrana is a chronic wound (∼Non-Healing Ulcer) and it is a frequently facing problem in general clinical practice. In Ayurveda many number of Vrana Shodhana(Wound cleansing) and Ropana(Healing) drugs are mentioned by our ancient Seers. Keeping the above challenge in view Aragwadha+Karanja+Babool twak Kashaya(Decoction) has been selected from the list of drugs for Externally cleansing the wound and Internal administration 20ml OD, these drugs possessing Vrana Shodhana and Ropana properties in Jathyadi taila. Panchatikta Ghrita Guggulu and Gandhaka Rasayana was given as Internal medication. The study was conducted in the OPD of Dr. B.R.K.R. Government Ayurvedic Hospital, Hyderabad and it has given promising results. As the drugs are easily available around and cost effective, this study will be definitely helpful for treating Dushtavrana(∼Non-Healing Ulcer) successfully. The present study with photographical evidences will give a ray of hope for the young research workers to conduct clinical trials in large number of cases so as to give authenticity for the present study.

Case of infertility in which cause remains unknown or idiopathic is considered as an unexplained infertility. Literally the couple who fails to conceive within one year of unprotected coitus with normal investigations of both the partners is termed as Unexplained infertility. Globally about 10-30% of infertility cases are diagnosed as unexplained infertility. Day by day the prevalence rate is rising due to change in lifestyle, unhealthy food habits, drinking alcohol & smoking addiction and stress. In Ayurveda Acharyas have given detailed description of infertility and it’s line of treatment with many formulations. In present scenario a case of 30 years female was undertaken who had visited our OPD of DAMCH, Udgir with complaints of anxious to conceive and trying for that from last 3 years. The couple was examined and investigated after which diagnosed as unexplained infertility because all the investigations were absolutely normal. As Acharyas have given line of treatment for infertility we gave her Shodhan chikitsa first followed by Shaman and Garbhasthapak chikitsa, as a result we got positive pregnancy test indicating conception within 6 months with healthy pregnancy.

Hypothyroidism, described by deficient thyroid chemical creation, is a common endocrine problem influencing millions around the world. Its side effects incorporate exhaustion, weight gain, and mental impedance, altogether influencing personal satisfaction. While customary Ayurvedic writing examines Galganda, much the same as hypothyroidism, direct notices of thyroid problems are restricted. In this unique situation, this study investigates the capability of Jalakumbhi Lavana joined with Pippali in overseeing hypothyroidism, drawing matches with current ways to deal with its treatment. Jalakumbhi, referred to naturally as Pistia stratiotes, has phytochemical constituents possibly valuable in thyroid capability adjustment. Lavana Kalpana, a plan including salts, including normal salt (Saindhava Lavana), helps with drug conveyance and retention. Furthermore, it goes about as a potentiate, upgrading helpful impacts. The cooperative energy between Jalakumbhi Lavana and Pippali, a notable Ayurvedic spice with mitigating and bio enhancing properties, offers a promising road for tending to hypothyroidism.

Nature is considered as a mighty healer for human beings since ages. It is undoubtful that Plants offers a plentiful reservoir of medicinal compounds. Among these, secondary metabolites are the phytochemicals produced as a result of protection against pathogens, herbivorous animals, and other environmental stress factors. Phytoncides are Volatile Organic Compounds (VOC’s) produced by the plants in order to protect themselves from bacteria, fungi, insects and other organisms and are released into the air, thereby forming a protective environment around the plant. These phytoncides which are mostly of isoprene origin has exhibited various pharmacological activities. Researches have found that forest bathing or prolonged exposure to forest volatile oils can have a profound impact on both physical and mental well being of humans. Since these chemicals act mainly by stimulating olfactory receptors and interacting with nasal mucous membranes, they can be considered similar to aromatherapy. Aromatherapy basically works through olfactory system as well as through dermal absorption. Both share some general health benefits like enhancing immunity by increasing NK cell activity and reducing the mental stress. Recently, many expert scientists around the world has developed new concepts like forest medicine and forest therapy, which may open up ways for in depth study of this topic.