Discovery Programme

Abstract Objectives(1) determine if there is a correlation between disability, depression, and wellbeing in people with IBM, (2) determine if disability and depression can predict wellbeing in people with IBM, and (3) identify the prevalence of depression and impaired wellbeing in participants with IBM.MethodsIn this cross-sectional study, 101 participants with IBM completed the Neuromuscular Symptom Score (NSS), Personal Wellbeing Index (PWI), and Patient Health Questionnaire-9 (PHQ-9) surveys to serve as surrogate measures of physical disability, wellbeing, and depression respectively.ResultsLinear regression identified that PHQ-9 significantly predicts PWI, however NSS does not, with a negative predictive value of depression for wellbeing (−2.7513, p < 0.001) and a positive predictive value of disability for wellbeing (0.0575, p = 0.764). Moderate to severe depression was reported in 78.2% of participants, and all but one participant reported reduced wellbeing.ConclusionsDepression is a more significant predictor of wellbeing than disability in participants diagnosed with IBM. There was a high prevalence of depression and reduced wellbeing in participants, highlighting the importance of assessing these factors to optimise treatment in IBM.

ABSTRACTThe origin of Ireland’s fauna is an unresolved issue in the history of the island. Although researchers once considered Ireland’s mammals to have spread to Ireland during the early postglacial from 11,700 cal BP, research has increasingly suggested humans translocated many of these species to Ireland. However, due to sparse evidence, the origin of Ireland’s purported native mustelid species remains unanswered. In this study, we shed light on the history of otter and badger in Ireland by directly dating suspected early examples of these species from Derragh, Co. Longford, a late Mesolithic campsite. The results demonstrate that both of these species have been present in Ireland for at least 7000–8000 years. It is not clear if they represent self-colonisers or Mesolithic anthropogenic translocations. Although these finds do not rule out local extinction and later reintroduction, they show that we can no longer assume they are solely late Holocene introductions.

The discovery of a major archaeological complex at Faughan Hill, County Meath, was first reported on in the Proceedings of the Prehistoric Society in 2015. Comprising a series of large hilltop enclosures, probable burial sites, and associated features, the character and scale of the complex marked this out as an important focal centre in a region populated with some of Ireland’s largest and most spectacular monument ensembles, not least at the Hill of Tara, 15 km to the south-east. A more complete picture of the site has since been revealed through further geophysical survey followed by test excavations by the Discovery Programme’s Tara Research Project. Two trenches excavated across the hilltop enclosures in 2017 yielded evidence of four discrete phases of activity spanning some 3000 years, from the mid-4th to mid-1st millennia bc. During the Middle Neolithic the hilltop was encircled by a fenced enclosure (3635–3380 cal bc) possibly associated with the production of stone tools. At 250 m in projected diameter it is one of the largest enclosures of the 4th millennium known in Ireland. This was superseded in the Late Bronze Age by a far more substantial, 400 m diameter multivallate enclosure (1280–920 cal bc) representing the only excavated hillfort of its type in Meath. The hill was the focus of renewed activity during the Early Iron Age (800–520 cal bc) and later became central to the political ambitions of aspiring, early Uí Néill kings of Tara, achieving particular reknown as the burial place of their eponymous ancestor, Niall of the Nine Hostages. Developments at Faughan are illuminated further by a wealth of prehistoric settlement and ritual sites in the surrounding area, as well as early documentary sources, and, collectively, speak to a regional centre and gathering place with long-lived social, symbolic, and political significance.

The Infrastructure for Spatial Information in Europe (INSPIRE) Directive (2007) requires public organisations across Europe to share environmentally-related spatial datasets to support decision making and management of the environment. Despite the environmental focus of INSPIRE, it offers limited guidance for archaeological datasets. Most primary data is created outside, but ultimately curated within, the public sector. As spatial evidence from fieldwork activities is not considered by the Directive, it overlooks a range of barriers to sharing data, such as project-based fieldwork, a lack of data standards, and formatting and licencing variations. This paper submits that these challenges are best addressed through the formalised management of primary research data through an archaeological Spatial Data Infrastructure (SDI). SDIs deliver more efficient data management and release economic value by saving time and money. Better stewardship of archaeological data will also lead to more informed research and stewardship of the historic environment. ARIADNE already provides a digital infrastructure for research data, but the landscape and spatial component has been largely overlooked. However, rather than developing a separate solution, the full potential of spatial data from archaeological research can and should be realised through ARIADNE.

Shotgun metagenomics applied to archaeological feces (paleofeces) can bring new insights into the composition and functions of human and animal gut microbiota from the past. However, paleofeces often undergo physical distortions in archaeological sediments, making their source species difficult to identify on the basis of fecal morphology or microscopic features alone. Here we present a reproducible and scalable pipeline using both host and microbial DNA to infer the host source of fecal material. We apply this pipeline to newly sequenced archaeological specimens and show that we are able to distinguish morphologically similar human and canine paleofeces, as well as non-fecal sediments, from a range of archaeological contexts.

ABSTRACTShotgun metagenomics applied to archaeological feces (paleofeces) can bring new insights into the composition and functions of human and animal gut microbiota from the past. However, paleofeces often undergo physical distortions in archaeological sediments, making their source species difficult to identify on the basis of fecal morphology or microscopic features alone. Here we present a reproducible and scalable pipeline using both host and microbial DNA to infer the host source of fecal material. We apply this pipeline to newly sequenced archaeological specimens and show that we are able to distinguish morphologically similar human and canine paleofeces, as well as non-fecal sediments, from a range of archaeological contexts.

As a partner in the EU co-funded 3D-ICONS project, the Discovery Programme has surveyed a wide range of the iconic cultural heritage sites in Ireland. This project aimed to establish a complete pipeline for the production of 3D replicas of archaeological monuments and historic buildings, and to publish the content to Europeana for public access. Challenges discussed include: making such high resolution data sets available to the public to enable online interaction and via the web, creating suitable and representative metadata and IPR frameworks for 3D cultural heritage data.

Whilst fragment-based screening has found significant utility in aiding the discovery of high quality hits against a range of targets, the use of this technology in the protein-protein interaction inhibitor field is very much in its infancy. This review aims to highlight the key technologies used to identify fragment hits, such as NMR, SPR, X-ray crystallography and biochemical screening, the fragment-based protein-protein interaction case studies reported to date and, more importantly, the potential of this methodology in unearthing high quality hit molecules in this critical area of drug discovery. In addition, we also discuss some of the key aspects of fragment library design, the composition of a high quality library and suggest ways in which future, more structurally diverse fragments which occupy different regions of chemical space to the vast majority of current fragment libraries may be selected.