ESI Group (United States)

El cortesano descortés es una de las piezas en las que Salas Barbadillo mejor examina la intimidad masculina mediante la creación de un personaje excéntrico cuyas desgracias se convierten en objeto de burla. Esta burla presenta una noción de lo íntimo como una zona de intercambio en donde las fronteras están constantemente negociadas y reconfiguradas, y en donde el cuerpo se somete a un proceso de exhibición constante. Con ello Salas logra no solo una fértil crítica del urbanita barroco, sino también un muy moderno concepto del espacio doméstico masculino y, por extensión, de lo que se concibe como íntimo y privado.

DaxibotulinumtoxinA for injection (DAXI), the first long-acting botulinum toxin (BoNT) type A, is FDA approved for cervical dystonia (CD). DAXI's novel formulation, which includes a custom-engineered peptide, is designed to provide an extended duration of clinical benefit. To evaluate the pooled efficacy and safety of DAXI for CD across two phase 3, multicenter, randomized, double-blind, placebo-controlled trials: ASPEN-1, conducted in North America and Europe, and ASPEN-1-CN, a similarly designed, smaller pivotal clinical trial, conducted in China. Adults with moderate-to-severe CD were randomized (3:3:1) to receive DAXI 125U, DAXI 250U, or placebo. The primary endpoint was change from baseline in Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) total score averaged across weeks 4 and 6. A key secondary endpoint was duration, defined as time until loss of >80% of peak effect. In all, 357 subjects were randomized and received DAXI 125U (n=149), DAXI 250U (n=154), or placebo (n=54). DAXI 125U (-12.0) and DAXI 250U (-11.9) significantly improved the mean TWSTRS total score versus placebo (-4.6; P<0.0001). Median (95% CI) duration of effect was 24.1 (20.6-28.9) weeks for DAXI 125U and 22.0 (20.1-24.3) weeks for DAXI 250U. Rates of treatment-related dysphagia (125U: 4.7%, 250U: 4.5%) and muscle weakness (125U: 5.4%, 250U: 4.5%) were low for both active doses. This pooled analysis of two phase 3 trials demonstrates that DAXI is an effective, safe, and long-acting treatment for CD. Key adverse events occurred at rates lower than prior pivotal trials of BoNTs for CD.

This paper investigates the possibility of utilizing response from natural ice loading for modal parameter identification of real offshore platforms. The test platform is the JZ20-2MUQ jacket platform located in the Liaodong Bay, China. A field experiment is carried out in winter season, as the platform is excited by floating ices. The feasibility is demonstrated by the acceleration response of two different segments. By the SSI-data method, the modal frequencies and damping ratios of four structural modes can be successfully identified from both segments. The estimated information from both segments is almost identical, which demonstrates that the modal identification is trustworthy. Furthermore, by taking the Jacket platform as a benchmark, the numerical performance of five popular time-domain EMA methods is systematically compared from different viewpoints. The comparisons are categorized as: (1) stochastic methods versus deterministic methods; (2) high-order methods versus low-order methods; (3) data-driven versus covariance-driven stochastic subspace identification methods.

In the following paper, a flip-chip package structure (Silicon die) is modeled using electronics cooling solver ESI Presto. Two numerical approaches are used to model large number of power sources referred to as “Power Map”. First approach is to model sources as rectangular patches on a surface. This approach requires geometry re-meshing. Second approach is to model sources as points which eliminates the need to re-mesh. Hence, large number of sources can be modeled without increases the grid count or simulation execution time. Results from these two approaches are compared and they match very well for the current mesh. A parameter sensitivity analysis is performed by varying power map parameters such as power amplitude, Gaussian pulse width and location on the die. The relation between input power and average temperature rise is linear in these simulations as expected. The point source method is used to demonstrate a case with very large number (10,000) of sources.

Abstract This paper specifies the panel data experimental design condition under which ordinary least squares, fixed effects, and random effects estimators yield identical estimates of treatment effects. This condition is relevant to the large body of laboratory experimental research that generates panel data. Although the point estimates and the true standard errors of the estimated average treatment effects are identical across the three estimators, the estimated standard errors differ. A standard F test as well as asymptotic reasoning guide the choice of which estimated standard errors are the appropriate ones to use for statistical inference.

A generic numerical method for predicting the wave propagation in structures with two-dimensional periodicity is presented. The method is based on a combination of Finite Elements and periodic structure theory. A unit cell of the periodic structure is described with finite elements, and a Craig-Bampton reduction is applied to reduce the number of degrees of freedom. Periodic boundary conditions are then applied and the waves propagating in the structure are obtained by solving an algebraic eigenvalue problem. A number of analytical expressions are then used to derive the vibro-acoustic properties of the finite or infinite periodic structure. The method was recently extended to account for heavy fluid loading and material with frequency-dependent properties (typical of acoustic treatments). A number of examples are presented to validate the formulation and demonstrate the possible use of the method for design.

This paper is concerned with the validity domain of SEA which is defined in terms of four criteria. The mode count N and the modal overlap M must be high, the normalized attenuation factor m and the coupling strength gamma must be small. The application of the dimensional analysis on the governing equations of plates gives the space of dimensionless parameters in which the validity domain of SEA must be delimited. This domain is discussed on the basis of the geometric properties of the surfaces delimiting it. The diagrams of validity of SEA are introduced and proposed as a tool for a practical use of SEA.

&lt;div class="htmlview paragraph"&gt;This paper describes a number of recent advances in the prediction of automotive interior noise. A brief review of existing modeling methods is given. Recent advances are then discussed in the following areas: (i) low frequency FE models, (ii) airborne SEA models, (iii) structure-borne SEA models and (iv) the use of CFD for source modeling.&lt;/div&gt;

Abstract This paper describes the development of an integrated Finite Element model combining the vehicle structure, dummy and air bag subsystem in one system. The model was developed to simulate vehicle frontal crash into a rigid barrier with an initial velocity of 13.4 m/s (30 m.ph). The predicted vehicle velocity agreed quite well with available experimental data. The model was subsequently exercised to simulate the New Car Assessment Program (NCAP), impact into a 50% offset barrier and impact into a rigid pole. Vehicle deformations and dummy kinematics are presented and discussed.