Euroconsultants (Greece)

Introduo: o Angioedema Hereditrio (AEH) uma doena rara e hereditria, caracterizada por episdios recorrentes de inchao (edema) nas camadas profundas da pele, mucosas e tecidos subcutneos, frequentemente resultando em complicaes graves, como obstruo das vias areas.A deficincia ou disfuno do C1 inibidor, uma protena chave do sistema complemento, est no cerne da patognese da doena.Embora o tratamento de crises agudas seja essencial, as abordagens profilticas so fundamentais para a preveno de episdios e melhora da qualidade de vida dos pacientes.Objetivos: o objetivo deste trabalho realizar uma reviso abrangente das abordagens profilticas no AEH, avaliando as estratgias disponveis e os resultados clnicos associados a diferentes tratamentos, com nfase nas opes mais eficazes e nas diretrizes atuais para manejo da doena.Metodologia: foi conduzida uma reviso integrativa de estudos nos ltimos 5 anos.Foram considerados ensaios clnicos, estudos observacionais, revises de estudos, editorial e carta.A anlise inclui diversas abordagens profilticas, tais como eficcia do lanadilumabe, inibidores de C1, profilaxia de longo prazo com danazol e edio gentica com Crispr-Cas9 de KLKB1.Resultados: Esta reviso integrativa analisou as principais profilaxias para os impactos causados ao paciente pelo angioedema hereditrio com nfase na vistoria de seus trs tipos principais de interveno: curto prazo, longo prazo e em demanda.Os estudos revisados indicaram que a profilaxia longo prazo demonstrou eficcia superior na reduo da frequncia e gravidade dos episdios de edema e suas complicaes.Ademais, ensaios empricos demonstraram maior eficcia profilaxia ao produzir um tratamento individualizado, visto que os efeitos colaterais podem ser reduzidos ao avaliar a concentrao dos medicamentos utilizados.Entretanto, o surgimento de novos protocolos e tratamentos mais eficazes torna-se necessrio para estabelecer diretrizes clnicas.Concluso: a profilaxia no Angioedema Hereditrio crucial para melhorar a qualidade de vida dos pacientes e evitar complicaes graves.O tratamento deve ser personalizado, levando em conta as necessidades

Paralisia Cerebral (PC) é uma desordem neurológica que ocorre em crianças de 0 até 5 anos de idade, podendo resultar em comprometimento importante nos sistemas neuro motor, musculoesquelético, sensorial, visual, cardio respiratório e gastrointestinal. O comprometimento visual pode acarretar déficit no desenvolvimento cognitivo e motor, devido a limitação da percepção espacial e sensorial que a baixa visão provoca. Em vista dos problemas apresentados pela PC e da baixa visão, a tecnologia assistiva (TA) surge como um recurso que melhora a capacidade funcional e a interação com o ambiente. Essa pesquisa teve como objetivo desenvolver uma revisão que procurou mostrar como a TA melhora a saúde e a qualidade de vida da criança afetada. As fontes científicas utilizadas nessa pesquisa foram as seguintes: Lilacs, Scielo, PubMed e Elsevier, no qual obteve-se informações das TAs aplicadas às crianças com PC associados a baixa visão e da relevância do tratamento precoce e integral. Destacam-se a necessidade de um ambiente com intensidade luminosa controlada, brinquedos com sons e formas adaptadas com texturas diferenciadas permitindo o manuseio e a interação dos olhos, mãos e ambiente. Esses recursos tecnológicos produzem maior adaptabilidade da visão, motora, percepção sensorial, etc. Ficou constatado que a intervenção precoce interdisciplinar com uso dos recursos mencionados, reduz os efeitos causados pela PC e baixa visão, favorecendo o desenvolvimento neuropsicomotor da criança. Essa pesquisa possui o potencial para agregar novos conceitos e aplicações nas atividades terapêuticas desenvolvidas.

Two large-scale plate load tests were carried out at the foundation level of the Santorini 150 kV GIS Substation, where the subsoil was identified as collapsible. The purpose of these load tests was to establish in-situ, the magnitude of the expected settlements due to the collapse of the subsoil structure after inundation, while applying a bearing pressure equal to the maximum expected according to the structural design. After completion of the tests, which are described in detail, the resulting settlements were found to be acceptable, so no soil improvement measures were required and it was concluded that with the design and execution of these innovative load tests, it was possible to measure under actual field conditions the magnitude of settlement due to collapse of the soil structure. This led to a more economical foundation solution, compared to the one that would have been adopted were only laboratory tests taken into account in the calculation of settlements.

Abstract The objective of this study was to find an optimum EOR strategy for a Middle-East offshore heavy-oil reservoir that exhibits reservoir-fluids-properties variations with depth using non-isothermal compositional simulations that honor the fluids-compositional variations with depth. The observed compositional variations are such that the oil density changes from 20 °API in the crest to 11 °API in the deep part and the live-oil viscosity increases from 14 cP in the crest part to 449 cP in the deep part of the reservoir. Because the concept of thermodynamic equilibrium is not valid for the reservoir with compositional variations, we used the theory of irreversible thermodynamics to develop a compositional PVT model that captures the observed compositional and oil-properties variations with depth. Next, the PVT model was tuned against CO2 and hydrocarbon-gas swelling and MMP tests. Subsequently, we developed a compositional reservoir dynamic model that uses the single compositional PVT model and can simulate the degree of CO2/hydrocarbon-gas miscibility in oil. Then, we performed a dynamic IOR/EOR screening that includes water injection, hydrocarbon-gas injection, CO2 injection, water-alternating-CO2 injection, polymer injection, polymer-alternating-CO2 injection (PAG-CO2), and simultaneous polymer and CO2 injection (SPCO2). For simultaneous polymer and CO2 injection, polymer was injected at the top while CO2 was injected at the bottom. The simulation runs of these scenarios were elucidated in detail. The developed compositional PVT model successfully reproduces the observed fluids-properties and compositional variations with depth. In this way, the calculated fluids properties are continuous with depth because there is only a single PVT model for a single PVT region. The performances of different EOR scenarios were compared with each other. The simulated incremental oil recovery increases in the sequence of water injection, hydrocarbon-gas injection, WAG-CO2 injection, CO2 injection, polymer (22 cP) injection, PAG-CO2, and SPCO2. The reason for higher incremental recoveries with combined CO2-polymer scenarios is that both the macroscopic sweep (with polymer) and microscopic displacement efficiency (with CO2 and polymer) remain high. Although the CO2 injection pressure is lower than the MMP, the condensing- and vaporizing-gas drives are very efficient to the remaining oil saturation to low values (< 0.10). The other advantage of SPCO2 injection is that the intermediate and deep layers are well contacted and swept by the injected fluids. At the crest scale, combined CO2-polymer scenarios can increase the do-nothing recovery by 85–119%.

The MOMPA project (MOnitoring of ground Movements and Action Protocol) has been co-financed by the European Regio- nal Development Fund through the Interreg V-A Spain-France-Andorra programme (POCTEFA 2014-2020). The project addresses landslide risk management based on satellite radar interferometry (InSAR) technique. Starting from the interre- gional scale ground displacement map (covering around 4,000 km2) and the detected Active Deformation Areas (ADA), a local scale analysis (integrating InSAR and traditional methods) will be performed on a selection of the ADA with a high potential risk. Then, the InSAR monitoring technique will be integrated in an action protocol for Civil Protections. The study area of the project is in the Eastern Pyrenees, covering the whole Principality of Andorra, the Spanish areas of Alt Urgell and Cerdanya (Catalonia) and the French areas of Cerdanya-Capcir and Conflent (Occitanie). Both the medium-resolution, free data acquired by Sentinel-1, and the high-resolution data acquired by COSMO-SkyMed are used. A specific case study, of high interest for Andorra, is a landslide located in Andorra that could affect the only access to Andorra from Spain. In this case, artificial reflectors have been installed along the forested steep slope, to have InSAR measures to be integrated with the ongoing activities of traditional monitoring.

Na logística de entregas um dos maiores desafios e a elaboração das rotas dos veículos que minimize os deslocamentos e seja realizada em tempo aceitável. Uma abordagem para a otimização do roteamento é a baseada na solução do problema Team Orienteering Problem (TOP). Entretanto, assim como o TSP, o TOP também é um problema de complexidade computacional NP-Hard. Portanto, deve ser resolvido com o auxílio de abordagens metaheurísticas. Nesse sentido, este trabalho apresenta uma abordagem de solução do TOP enquadrada para problemas de otimização de rotas logísticas. Tal abordagem visa o desenvolvimento de um algoritmo baseado na metaheurística GRASP conjugada com a técnica de intensificação de resultados Path Relink. Os resultados alcançados demonstram que algoritmo proposto alcançou os resultados encontrados na literatura para 46,5% das instâncias executadas, indicando resultados promissores para um trabalho em desenvolvimento.

Abstract Souring potentials of fields during planned-waterflood development need to be investigated to enable the selection of the injection-water source and facility-design options. This paper presents the application of a novel reservoir-souring approach to assess the souring potential of a Middle-East field that is associated with three potential injection-water sources in terms of souring, to recommend ways to prevent or reduce H2S production, and to determine the optimum solution for injection water. The novel approach includes fluid sampling and analysis, a desktop study, a dynamic-reservoir simulation, and a surface-facility evaluation. In the desktop study, a qualitative assessment of souring associated with the three potential injection-water sources (shallow-aquifer water, produced water, and mixtures of produced and shallow water) and mitigation strategies to limit future H2S concentrations were carried out. Subsequently, a compositional non-isothermal dynamic model that includes 3 phases, 18 components, and 18 reactions was developed to quantitatively predict the most-likely and the worst-case H2S levels over the field’s life. Several sensitivity runs were performed to assess the impact of the key uncertain parameters on the H2S level. The results indicate that re-injection of produced water (deep aquifer) with a salinity of 173,000 mg/l not only has a very low souring risk, but also offers the most manageable conditions in terms of scaling and corrosion control for both the reservoir and the facilities. For this water, the simulated earliest H2S-breakthrough time is year 2038 and the H2S concentration in the gas phase will not exceed 1000 ppmv until 2074. On the other hand, injection of the shallow-aquifer water with a salinity of 11,000 mg/l has a high risk of souring. The simulated earliest H2S-breakthrough time is 2025 and after breakthrough within one year the gas-phase H2S concentration reaches 1,500 ppmv at ambient conditions. When mixtures of produced and shallow-aquifer water are used, the risk of souring depends on the mixture salinity; if it would be higher than 150,000 mg/l, the souring risk would still be very low, otherwise the souring risk would be moderate to high. In terms of mitigations, nitrate injection is very effective in significantly reducing the high souring risk of injecting the shallow-aquifer water. Stripping out the dissolved H2S in the shallow-aquifer water can delay the H2S-breakthrough time by 11 years and can reduce the max H2S concentration by 50%.