European University of Brittany

ABSTRACT This study aimed to assess the effectiveness of online emotional competencies (EC) training, and more specifically the relationships between adherence, confidence, and alliance and the effects of mental training on EC. A longitudinal four-wave measurement design (pre-intervention, post-knowledge development, post-abilities development, and post-disposition phase) was used in the present study. An experimental group (n = 20) received a specific EC training intervention, whereas the control group (n = 20) did not receive this intervention program. These two groups completed self-report questionnaires assessing emotional regulation and EC across four measurement times. Participants of the intervention group also completed a questionnaire measuring the adherence, confidence, alliance between practitioner and athlete. Results of repeated measure ANOVAs showed that the level of EC increased significantly in the intervention group but not in the control group. Moreover, correlation analyses highlighted significant relationships between the scores of adherence, confidence, alliance between the practitioner and the tennis player, and the scores difference of EC between before and after intervention. These outcomes suggest the possibility of improving EC with an online intervention. The online device did not affect the quality of the alliance between the practitioner and the intervention participant. Furthermore, the results showed that a high level of alliance, confidence, and adherence was associated with an improvement in emotional intelligence. This online program would serve psychologists and mental trainers to use an intervention to develop EC adapted to the constraints of the localisation of athletes.

Abstract In this study, the kinetic degradation of the anti-inflammatory drug Ibuprofen in aqueous solution by heterogeneous TiO2 photocatalytic was investigated. The data obtained were used for training an artificial neural network. Preliminary experiments of photolysis and adsorption were carried out to assess their contribution to the photocatalytic degradation. Both, direct photolysis and adsorption of Ibuprofen are very low-efficient processes (15,83% and 23,88%, respectively). The degradation efficiency was significantly elevated with the addition of TiO2 Catalyst (>94%). The photocatalytic degradation followed a pseudo-first-order reaction according to the L-H model. The hydroxyl radicals and photo-hole (h+‏) were found to contribute to the Ibuprofen removal. The higher the initial concentration of Ibuprofen resulted in the lower percentage of degradation. This can be credited to the fact that the created photon and radicals were constant. The higher the initial concentration of Ibuprofen the fewer radicals were shared for each Ibuprofen molecular and so the lower percentage of degradation. The maximum photoactivity from the available light is accomplished when the concentration of catalyst reaches to 1 g/L (0.8 g), which was adopted as the optimal amounts. Compared to the removal of ibuprofen, the mineralization was relatively lower. This decrease is due to the organic content of the treated solution, which is mainly composed of recalcitrant intermediate products. The network was planned as a Levenberg-Marquardt algorithm with three layer, four neurons in the input layer, fourteen neurons in the hidden layer and one neuron in the output layer (4:14:1). The artificial neural network was trained until the MSE value between the simulated data and the experimental results was 10−5. The best results (R 2 = 0.999 and MSE = 1.5 × 10−4) were obtained with a log sigmoid transfer function at hidden layer and a linear transfer function at output layer.

BackgroundIndividual studies have reported widely variable rates for VTE and bleeding among hospitalized patients with coronavirus disease 2019 (COVID-19).Research QuestionWhat is the incidence of VTE and bleeding among hospitalized patients with COVID-19?MethodsIn this systematic review and meta-analysis, 15 standard sources and COVID-19-specific sources were searched between January 1, 2020, and July 31, 2020, with no restriction according to language. Incidence estimates were pooled by using random effects meta-analyses. Heterogeneity was evaluated by using the I2 statistic, and publication bias was assessed by using the Begg and Egger tests.ResultsThe pooled incidence was 17.0% (95% CI, 13.4-20.9) for VTE, 12.1% (95% CI, 8.4-16.4) for DVT, 7.1% (95% CI, 5.3-9.1) for pulmonary embolism (PE), 7.8% (95% CI, 2.6-15.3) for bleeding, and 3.9% (95% CI, 1.2-7.9) for major bleeding. In subgroup meta-analyses, the incidence of VTE was higher when assessed according to screening (33.1% vs 9.8% by clinical diagnosis), among patients in the ICU (27.9% vs 7.1% in the ward), in prospective studies (25.5% vs 12.4% in retrospective studies), and with the inclusion of catheter-associated thrombosis/isolated distal DVTs and isolated subsegmental PEs. The highest pooled incidence estimate of bleeding was reported for patients receiving intermediate- or full-dose anticoagulation (21.4%) and the lowest in the only prospective study that assessed bleeding events (2.7%).InterpretationAmong hospitalized patients with COVID-19, the overall estimated pooled incidence of VTE was 17.0%, with higher rates with routine screening, inclusion of distal DVT, and subsegmental PE, in critically ill patients and in prospective studies. Bleeding events were observed in 7.8% of patients and were sensitive to use of escalated doses of anticoagulants and nature of data collection. Additional studies are required to ascertain the significance of various thrombotic events and to identify strategies to improve patient outcomes.Trial RegistryPROSPERO; No.: CRD42020198864; URL: https://www.crd.york.ac.uk/prospero/.

Aim: Several series have already demonstrated that intratumoral subvolumes with high tracer avidity (hotspots) in 18F-flurodesoxyglucose positron-emission tomography (FDG-PET/CT) are preferential sites of local recurrence (LR) in various solid cancers after radiotherapy (RT), becoming potential targets for dose escalation. However, studies conducted on head and neck squamous cell carcinoma (HNSCC) found only a moderate overlap between pre- and post-treatment subvolumes. A limitation of these studies was that scans were not performed in RT treatment position (TP) and were coregistred using a rigid registration (RR) method. We sought to study (i) the influence of FDG-PET/CT acquisition in TP and (ii) the impact of using an elastic registration (ER) method to improve the localization of hotpots in HNSCC.Methods: Consecutive patients with HNSCC treated by RT between March 2015 and September 2017 who underwent FDG-PET/CT in TP at initial staging (PETA) and during follow-up (PETR) were prospectively included. We utilized a control group scanned in non treatment position (NTP) from our previous retrospective study. Scans were registered with both RR and ER methods. Various sub-volumes (AX; x = 30, 40, 50, 60, 70, 80, and 90%SUVmax) within the initial tumor and in the subsequent LR (RX; x = 40 and 70%SUVmax) were overlaid on the initial PET/CT for comparison [Dice, Jaccard, overlap fraction = OF, common volume/baseline volume = AXnRX/AX, common volume/recurrent volume = AXnRX/RX].Results: Of 199 patients included, 43 (21.6%) had LR (TP = 15; NTP = 28). The overlap between A30, A40, and A50 sub-volumes on PETA and the whole metabolic volume of recurrence R40 and R70 on PETR showed moderate to good agreements (0.41–0.64) with OF and AXnRX/RX index, regardless of registration method or patient position. Comparison of registration method demonstrated OF and AXnRX/RX indices (x = 30% to 50%SUVmax) were significantly higher with ER vs. RR in NTP (p < 0.03), but not in TP. For patient position, the OF and AXnRX/RX indices were higher in TP than in NTP when RR was used with a trend toward significance, particularly for x=40%SUVmax (0.50±0.22 vs. 0.31 ± 0.13, p = 0.094).Conclusion: Our study suggested that PET/CT acquired in TP improves results in the localization of FDG hotspots in HNSCC. If TP is not possible, using an ER method is significantly more accurate than RR for overlap estimation.

In this paper, we present a novel approach to simulate wayfinding behaviour of pedestrians familiar with their environment. This approach is inspired from spatial cognition and space syntax domains in order to achieve naturally crowd navigation. Therefore, the proposed wayfinding process is incremental; route choice decisions are made at every street junction, taking into account spatial configuration and individual knowledge of the environment as well as individual preferences. An adequate environment description is provided; it is a graph automatically generated, informed with pre-calculated data, that is used by agents to quantify the benefit cost of a route choice. The environment description is also used to endow agents with mental maps which contain the regions supposed to be experienced by them without going through a learning phase. Obtained results demonstrate that, under our model, agents calculate paths that have the same characteristics as those chosen by pedestrians familiar with their surroundings.

The treatment of melanoma requires early diagnosis and extensive surgical removal of the primary tumor. The differential diagnosis between a melanoma and a nevus is sometimes difficult from a histopathologic point of view and could require ancillary diagnostic tools. Recently, both fluorescent in situ hybridization (FISH) and p16-Ki67-HMB45 combined immunohistochemistry have been proposed as examples of ancillary diagnostic methods to help classify melanocytic tumors as benign or malignant. In this study, we compare FISH and p16-Ki-67-HMB45 immunohistochemistry in a set of melanomas and nevi. A total of 101 formalin-fixed and paraffin-embedded tumor samples (44 melanomas and 57 nevi) were analyzed using FISH for chromosomes 6, 8, 9, and 11 and p16-Ki-67-HMB45 immunohistochemistry. Any chromosomal imbalances and/or a p16-Ki-67-HMB45 immunohistochemistry combined score of 4 or higher were considered to reflect a "favor" malignant tumor. Using FISH, 42 out of 44 melanomas presented at least 1 chromosomal imbalance, whereas 2 melanomas and all nevi did not. Each melanoma, including 6 challenging tumors, had a p16-Ki-67-HMB45 immunohistochemistry combined score of 4 or higher and every nevus had a score inferior to 4. This reflects an excellent strength of agreement between FISH, immunohistochemistry, and definitive histopathologic diagnosis in our tumor set. We conclude that both FISH and p16-Ki67-HMB45 combined immunohistochemistry are valuable ancillary diagnostic tools to help pathologists classify melanocytic tumors as nevi or melanomas.

Introduction ‘Workaholism’, an addiction to work, is a pathology which has been recognised since the 1970s. It is generally found in around 10% of workers, yet one study on doctors working in a hospital environment demonstrated that 30% suffered from the condition. This study’s objective is to evaluate the prevalence of workaholism among doctors in a university teaching hospital, and to analyse the links to working conditions and the imbalance between effort and reward. Methodology Cross-sectional survey of doctors in a university teaching hospital, using an anonymous online questionnaire via Sphinx Online© software. The questionnaire consisted of general questions, specific questions on psychoactive substances (tobacco, alcohol, cannabis and others), Siegrist’s effort-reward imbalance questionnaire and the Work Addiction Risk Tests (WART) questionnaire. Results were analysed using Excel© and Biostatgv©. Reuslts There were 162 participants, a rate of 30% of relevant personnel. The principal psychoactive substance used by participants was alcohol: 81.3% of subject reported consuming it. An effort-reward imbalance was present in 18% of subjects who participated in the study. The risk of workaholic was identified in 48% of the cohort: 17% were high risk and 31% medium risk. There was a link between workaholism and effort-reward imbalance (p Conclusion The frequency of workaholism among doctors is much higher than the general population. From this study the link with work-related stress may help direct primary prevention efforts for this condition.