For farmers (United Kingdom)

Traditional extemporaneous compounding methods of solid oral dosage forms required in early-stage studies are laborious, and the drug's solid state may affect the biopharmaceutical performance of the medicine. Maintaining the intended drug form in all stages of drug product development is critical. In this study, we evaluated the potential of Semi-solid extrusion (SSE) 3D printing to maintain a crystalline solid dispersion and automate small-batch tablet production suitable for preclinical and first-in-human (FIH) studies using high-solubility acetaminophen and low-solubility celecoxib as model compounds. Two drug-loaded pharma-inks were developed for each drug, containing 0.22 % w/w and 23 % w/w acetaminophen, and 0.2 % w/w and 30 % w/w celecoxib, respectively. Dose-flexible tablets were printed by SSE 3D printing at room temperature, covering a wide range of acetaminophen doses (0.5 mg, 150 mg, and 250 mg), and celecoxib doses (0.5 mg, 100 mg, and 200 mg) from the low or high drug-loaded pharma-inks, respectively. In vitro drug release confirmed the immediate release properties of the tablets. X-ray diffraction and DSC of the tablets confirmed crystalline acetaminophen and celecoxib dispersions post-printing. This work demonstrates that SSE 3D printing technology can be employed as a straightforward and cost-effective method to rapidly manufacture small batches of dose-flexible oral solid dosage forms on demand, suitable for early-stage studies, while maintaining API crystallinity and providing flexible dosing.

Ildizpoyalari orqali vegetativ ko‘paytirilayotgan Bergenia crassifolia (L.) ning birinchi va ikkinchi yilgi vegetatsiyasi, o‘sishi va rivojlanishi kuzatildi. Introduktsiya sharoitida o‘simlikning yer ustki qismi va yer ostki qismi (ildizpoyalari) ning biomorfologiyasi va rivojlanish fazalari o‘rganildi. Toshkent sharoitida o‘stirilayotgan mazkur o‘simlikning assimilyatsiyalovchi organi (bargi) ning anatomik tuzilishi o‘rganilgan bo‘lib, diagnostik va moslashgan strukturaviy belgilar aniqlangan.

Program Beternak Kambing Perah Etawa merupakan salah satu program Bidang Ekonomi UPZ BAZNAS PT Semen Padang dengan menyaluran hibah 42 ekor ternak kambing perah peranakan etawa (PE) kepada tujuh Kepala Keluarga (KK) kurang mampu. Kambing perah dipilih karena memiliki potensi ekonomi yang tinggi. Tantangan dalam beternak kambing perah antara lain manajemen pakan, kesehatan ternak, serta teknik pemeliharaan yang buruk. Sistem pemeliharaan ternak kambing perah di masyarakat bersifat tradisional. Kualitas pakan yang buruk berdampak terhadap produksi, reproduksi maupun kesehatan ternak. Untuk mengefektifkan hibah kambing perah diperlukan pendampingan yang mampu memberikan bimbingan kepada peternak tentang aspek pakan, kesehatan dan pemeliharaan, sehingga budidaya ternak kambing dapat memberikan manfaat bagi peternak dan menjadi unit usaha keluarga. Kegiatan PKM dilakukan oleh Tim Pengabdi Fakultas Peternakan dan mahasiswa Program Studi Peternakan Universitas Andalas. Kegiatan berlangsung dari Bulan Juli hingga November 2024. Metode kegiatan PKM terdiri dari survei, penyuluhan dan evaluasi kegiatan. Setelah kegiatan PKM terlihat perbaikan dalam manajemen pakan dan peternak terampil menangani penyakit scabies pada ternak. Berdasarkan kegiatan PKM yang telah dilakukan dapat disimpulkan pengetahuan peternak tentang manajemen pemeliharaan ternak kambing perah mengalami peningkatan, peternak terampil mengatasi penyakit scabies dengan pengobatan trasisional karena efektif dan lebih ekonomis.

Free range grazing ducks play a major role in rural economy of Asian countries in the form of meat and egg production. The present study reports a mixed infection of Tetrameres sp. and Echinostoma sp. in nomadic ducks from Orathanadu, Thanjavur district of Tamil Nadu, India. On post-mortem examination of two ducks with a history of enteritis revealed bright red nematodes in the proventricular mucosa and minute flukes in small intestine. Tetrameres sp. and Echinostoma sp. worms were identified based on morphological characteristics. Intestinal contents also revealed eggs of Tetrameres sp. and Echinostoma sp. Further snails were collected from the duck rearing areas and confirmed the release of Echinostome cercariae and the snails were also identified as Planorbis sp. The study emphasizes the significance of mixed helminthic infections in nomadic ducks from Thanjavur, Tamil Nadu.