Ford Otosan (Turkey)

Obesity, a prevalent and multifactorial disease, is linked to a range of metabolic abnormalities, including insulin resistance, dyslipidemia, and chronic inflammation. These imbalances not only contribute to cardiometabolic diseases but also play a significant role in cancer pathogenesis. The rising prevalence of obesity underscores the need to investigate dietary strategies for effective weight management for individuals with overweight or obesity and cancer. This European Society for the Study of Obesity (EASO) position statement aimed to summarize current evidence on the role of obesity in cancer and to provide insights on the major nutritional interventions, including the Mediterranean diet (MedDiet), the ketogenic diet (KD), and the intermittent fasting (IF), that should be adopted to manage individuals with overweight or obesity and cancer. The MedDiet, characterized by high consumption of plant-based foods and moderate intake of olive oil, fish, and nuts, has been associated with a reduced cancer risk. The KD and the IF are emerging dietary interventions with potential benefits for weight loss and metabolic health. KD, by inducing ketosis, and IF, through periodic fasting cycles, may offer anticancer effects by modifying tumor metabolism and improving insulin sensitivity. Despite the promising results, current evidence on these dietary approaches in cancer management in individuals with overweight or obesity is limited and inconsistent, with challenges including variability in adherence and the need for personalized dietary plans.

The cat gut-inhabitant conjoint microbiota is a peculiar ecosystem in relationship with several bodily functions and immunity. Gut microbiota dysbiosis could participate within autoimmune disease pathogenesis, whereas its niche, whether causative or influencing role regarding systemic immunity in autoimmune diseases, remains fugitive. The purpose of the present study was to identify gut microbiota alterations and probable mechanisms that participated in the development of Pemphigus foliaceus for a better understanding of future effective therapeutical armamentarium based on gut microbiota. In the present article, the authors investigated gut microbiota alterations to those of eight cats diagnosed with Pemphigus foliaceus. Furthermore, the study thoroughly analyzed pathogenic bacteria species as triggers of autoimmunity. The diagnostic algorithm involved two distinct sides: i) on referral with the first criteria was proof of evidence for possible autoimmunity, and ii) Pemphigus foliaceus diagnosis with relevant analytes. A total of eight cats were enrolled, and gut microbiomes were detected by the use of the MIDOG All-in-One Microbial Test targeting Next-Generation DNA Sequencing. By this methodology, we analyzed the dysbiosis network for bacterial kingdoms and determined the relationship between disease activity related to Pemphigus foliaceus and gut microbiota. The data showed increasing abundances of Collinsella, Lachnospiroceae, and Escherichia coli and decreasing Desulfovibrio piger, Prevotella copri, and Helicobacter cianedi among cats with pemphigus foliaceus. For the first time in Turkey, the gut microbiota of cats with pemphigus foliaceus were detected, the results of which could be cautiously taken into consideration for novel and effective therapeutical approaches.

Abstract Drilling glass fiber reinforced polymer matrix (GFRP) composites typically causes burrs, splintering, and microcracks within the GFRP structure, as well as delamination, fiber pull‐out, and thermal degradation of the polymer matrix. Designing and manufacturing molded‐hole GFRP components, as opposed to drilling, has recently been proposed as a promising method for overcoming the issues associated with drilling, for which there is limited research. Specifically, the mechanical response of molded‐hole GFRP has not been fully addressed in the literature. In the present study, molded and drilled GFRP composites with epoxy matrix were fabricated by hand lay‐up, and then the samples were analyzed utilizing experimental and numerical analysis techniques. Stress and strain analyses of GFRP samples were performed in Ansys Transient Structural Analysis. Although the fiber orientations of the layer geometries [0°/90°] and 3D models were the same, an additional layer was defined in the direction of the fiber orientation [45°/−45°] of molded‐hole composites to simulate the fiber accumulation effect. Experimental findings revealed that the flexural strength of molded composites was 12% greater than that of drilled composites. According to the numerical analysis, 98.7% proximity was achieved between the experimental and numerical results. Thus, the present study has provided numerical modeling to understand the flexural strength of molded composites for the first time, which will contribute to the increased use of molded composites in numerous applications in the fields of aerospace, automotive, and marine.Highlights Drilled‐ and molded‐hole GFRP composites were produced by hand lay‐up. Flexural properties of the composites were examined via 4P bending tests. Flexural strength of molded composites was higher than that of drilled ones. 98.7% proximity was achieved between the experimental and FEM results. A unified FEM method is proposed for the molded‐hole composites.

Türkiye Cumhuriyeti Birinci Dünya Savaşı’ndan sonra bağımsızlığına kavuşan ve iki savaş arası dönemde siyasi etkinliğini kurmaya çalışan bir devlet olarak bidayetinde hemen her konuda olduğu gibi havacılığı da milli bir dava olarak ele almıştır. İlerleyen yıllarda ise bağımsızlığının ve dünya siyasetinde yer edinmenin temel etkenlerinden birisi olarak havacılığa imkânları ölçüsünde önem vermiştir. Havacılık faaliyetlerinin dünyada meydana gelen savaşların gidişatını etkilediği bir dönemde Türk havacılığında meydana gelen gelişmelerin takip edilebilmesine imkân sağlayan Havacılık ve Spor Dergisi çalışmamızın merkezinde yer almaktadır. Çalışmada, Türk Hava Kurumu’nun resmî yayın organı olan dergi üzerinden havacılıkla ilgili gelişmelerin takip edilmesi hedeflenmiştir. Ayrıca Türk Hava Kurumu’nun havacılık faaliyetleri konusunda kamuoyu oluşturma politikası kapsamında dergiden ne şekilde istifade etmeye çalıştığının ortaya çıkarılması da hedeflenmektedir. Çalışmanın temel kaynağı olan Havacılık ve Spor Dergisi’nin yanında arşiv belgeleri, resmî gazete, bilimsel tez ve makalelerden istifade edilmiştir. Yukarıdaki amaçlara uygun olacak şekilde çalışmanın kapsamını oluşturan 1939-1945 yılları arasındaki dönemde havacılığa bakış, hava kuvvetlerinin savaş üzerindeki etkileri ve Türk havacılık faaliyetlerinin izleri dergiden takip ve analiz edilmiştir.