Forschungsinstitut für Anwendungsorientierte Wissensverarbeitung

Conscious experiences have many structural features. Consider how your color experiences have dimensions of variation corresponding to hue, saturation, and brightness, how your visual acuity decreases in precision from the center of your visual field to the periphery, how your pain experiences come in different magnitudes, or how your temporal experience seems to flow in a continuous stream. ‘Structuralism’, in the most general sense, may be defined as an approach to consciousness research where the central aim is to investigate the structures of conscious experiences. Given this broad definition, there are many varieties of structuralism. As examples, methodological structuralists think that scientific methods give us knowledge only about structural features of consciousness, while ontic structuralists think that all there is to consciousness is structure. But even those who deny those claims might still think that the proper aim of the science of consciousness is to investigate structure. The aim of this special volume is to bring these dispersed discussions together by organizing a collection of articles about the structures of conscious experiences and the roles that structure ought to play in consciousness research. The goal is to set a foundation and an agenda for a structuralist research program in the scie­nce of consciousness.

The population structure and life in rural areas have become more diverse in recent years due to the arrival and stay of refugees. The participation of the newcomers in the labour market is relevant on the one hand from the point of view of integration policy and for the regional economy, and on the other hand it fulfils various functions for them. However, little attention has been paid to the (potential) self-employment of newly arrived refugees in Germany. Using the example of the founding of grocery stores in rural areas of Germany, the aspirations of refugees on the labour market, the founding and business practices of operators and the perspectives of customers were examined from multiple perspectives. The qualitative interviews conducted with (potentially) self-employed newly arrived refugees and (semi-)standardized surveys of customers form the data basis for this paper. It is conceptually inspired by the state of research on migrant’s integration to work and immigrant entrepreneurship as well as the subform refugee entrepreneurship. Results show a variety of meanings of employment and a distinct desire for self-employment. Moreover, structural and individual obstacles could be identified in the foundation phase, while co-ethnic employment is considered crucial for the operation of a store.

Book Review

Meprin β is a metalloprotease associated with neurodegeneration, inflammation, extracellular matrix homeostasis, transendothelial cell migration, and cancer. In this study, we investigated two melanoma-associated variants of meprin β, both exhibiting a single amino acid exchange, namely, meprin β G45R and G89R. Based on the structural data of meprin β and with regard to the position of the amino acid exchanges, we hypothesized an increase in proteolytic activity in the case of the G45R variant due to the induction of a potential new activation site and a decrease in proteolytic activity from the G89R variant due to structural instability. Indeed, the G89R variant showed, overall, a reduced expression level compared to wild-type meprin β, accompanied by decreased activity and lower cell surface expression but strong accumulation in the endoplasmic reticulum. This was further supported by the analysis of the shedding of the interleukin-6 receptor (IL-6R) by meprin β and its variants. In transfected HEK cells, the G89R variant was found to generate less soluble IL-6R, whereas the expression of meprin β G45R resulted in increased shedding of the IL-6R compared to wild-type meprin β and the G89R variant. A similar tendency of the induced shedding capacity of G45R was seen for the well-described meprin β substrate CD99. Furthermore, employing an assay for cell migration in a collagen IV matrix, we observed that the transfection of wild-type meprin β and the G45R variant resulted in increased migration of HeLa cells, while the G89R variant led to diminished mobility.

Simulations are used in very different contexts and for very different purposes. An emerging development is the possibility of using simulations to obtain a more or less representative reproduction of organs or even entire persons. Such simulations are framed and discussed using the term ‘digital twin’. This paper unpacks and scrutinises the current use of such digital twins in medicine and the ideas embedded in this practice. First, the paper maps the different types of digital twins. A special focus is put on the concrete challenges inherent in the interactions between persons and their digital twin. Second, the paper addresses the questions of how far a digital twin can represent a person and what the consequences of this may be. Against the background of these two analytical steps, the paper defines first conditions for digital twins to take on an ethically justifiable form of representation.

We report the imaging of magnetic domains in ferromagnetic CoNiB nanotubes with very long aspect ratio, fabricated by electroless plating. While axial magnetization is expected for long tubes made of soft magnetic materials, we evidence series of azimuthal domains. We tentatively explain these by the interplay of anisotropic strain and/or grain size, with magneto-elasticity and/or anisotropic interfacial magnetic anisotropy. This material could be interesting for dense data storage, as well as curvature-induced magnetic phenomena such as the non-reciprocity of spin-wave propagation.