Fujifilm (Netherlands)

The growing need for sustainable, high-efficiency filtration materials has driven interest in biodegradable alternatives to polypropylene (PP)-based nonwovens, which dominate global production but generate severe environmental burdens. This study presents a comprehensive investigation of additive-free, low-viscosity biodegradable polylactic acid (PLA) melt-blown nonwovens, establishing relationships between processing parameters, fiber structure, crystallization, and electrostatic charging performance. Across 135 experiments, we reveal that die geometry, die-to-collector distance, polymer throughput, air pressure, and temperature jointly determine fiber morphology and crystallinity of PLA melt-blown nonwovens, thereby affecting the filtration performance. Clear process–structure–performance connections for PLA nonwovens were defined. PLA nonwovens with submicron fibers achieving >95% filtration efficiency at <160 Pa pressure drop were fabricated without post-charging, demonstrating the feasibility of scalable, biodegradable filter media. X-ray diffraction and thermal imaging reveal that in situ crystallinity can be tuned by air pressure, polymer throughput, and collection speed, which enhances thermal stability and supports long-term charge retention. Two-month charge decay tests further identify fiber diameter as the dominant factor in electret stability, with crystallinity playing a secondary but reinforcing role. By combining systematic experimentation with mechanistic insights, this work offers practical guidance for industrial-scale manufacturing of high-performance PLA nonwovens and advances the development of next-generation sustainable air filtration media. • Additive-free PLA melt-blown nonwovens fabricated with submicron fibers • Process parameters systematically linked to structure and filtration efficiency • In situ crystallization tuned by temperature, air pressure, and throughput • Crystallinity enhances thermal stability and supports long-term charge retention • PLA filters achieved >95% efficiency and <160 Pa pressure drop without post-charging

This article explores the challenges faced by a multifaith chaplaincy team in a Dutch health care organization when searching for a shared professional identity regarding the role of worldview and religion. Using boundary theory, we show how the diverse worldviews and the contradictory visions on their role for chaplaincy’s professional identity led to misunderstandings and conflict. However, open and respectful dialogue about these differences helped clarify disagreements and identify common ground. The findings suggest that in secular contexts worldview remains significant in chaplaincy and that engaging in dialogue about worldviews and seeking connections across differences is the basis for a shared professional identity.

Every year, tens of millions of cycling enthusiasts watch and read about the Tour de France, one of the largest sports events of the year. For hours on end, they wait in anticipation of the climax of the race, and these hours are filled by commentators and journalists with background information about riders, the course, history, cuisine, culture and architecture. Little do they realize that every day the peloton is actually setting out on a beautiful excursion through what is one of the most geologically and geographically diverse regions in the world. The Geo‐Sports project provides journalists, readers, and viewers with accessible excursion guides, in written and video format, on websites and social media. In this article, we explain the rationale and background of the project, and we hope you will join us in lifting the veil to expose the beauty of the natural world and its role in our society.

As food production dominates global freshwater consumption and nutrient discharge regulation tightens, the performance of novel technologies at applied scale needs to be studied to optimize water use and minimize environmental impact. Water reuse and the nutrient recovery from greenhouse wastewater were assessed utilizing one-pass capacitive electrodialysis (CED) at a pilot scale (19.32 m2 membrane area, 1–4 m3/day capacity), employing carbon-based electrodes. CED was optimized for key parameters, including applied voltage, cross-flow velocity, staging, water recovery, and varying feed concentrations. High-quality greenhouse irrigation water (conductivity<0.2 mS/cm and Na+ < 0.1 mmol/L) was produced, meeting specified guidelines. Na+ was retained less compared to Ca2+ and Mg2+ (86 % ± 4 %, 97 % ± 2 %, and 98 % ± 3 % removal, respectively) and nutrients concentration factors for K+, NO3− and PO43− reached up to 2.3 (596 ± 5 mg/L), 2.7 (1330 ± 20 mg/L), and 1.9 (130 ± 2 mg/L), respectively. There was no significant improvement in ion removal for all feed compositions beyond 12 V and 80 % water recovery. CED's specific energy consumption (SEC) with optimized parameters was 4-fold lower than the modeled RO system, and lower than previous electrodialysis studies. The highest SEC obtained was 0.24 kWh/m3. These findings suggest that CED is a promising technology for the greenhouse horticulture sector, aiding the move toward zero liquid discharge.

Appropriate cardiovascular animal models are urgently needed to investigate genetic, molecular, and therapeutic approaches, yet the translation of results from the currently used species is difficult due to their genetic distance as well as their anatomical or physiological differences. Animal species that are closer to the human situation might help to bridge this translational gap. The common marmoset (Callithrix jacchus) is an interesting candidate to investigate certain heart diseases and cardiovascular comorbidities, yet a basic functional characterization of its hemodynamic system is still missing. Therefore, cardiac functional analyses were performed by utilizing the invasive intracardiac pressure-volume loops (PV loop) system in seven animals, magnetic resonance imaging (MRI) in six animals, and echocardiography in five young adult male common marmosets. For a direct comparison between the three methods, only data from animals for which all three datasets could be acquired were selected. All three modalities were suitable for characterizing cardiac function, though with some systemic variations. In addition, vena cava occlusions were performed to investigate the load-independent parameters collected with the PV loop system, which allowed for a deeper analysis of the cardiac function and for a more sensitive detection of the alterations in a disease state, such as heart failure or certain cardiovascular comorbidities.

Abstract This chapter presents the most relevant advances achieved during the MIDES project in relation to material development of key elements for microbial desalination cells. The first section is devoted to electrodes. Providing a general overview of the requirements of carbon-based materials to serve either as anodes or cathodes for microbial desalination cells. Advances achieved during MIDES in the development of materials for anode and cathode application are listed. The second section is focussed on ion-exchange membranes for microbial desalination cells. General considerations for the use of these membranes are reported as well as key parameters. Finally, advances in ion-exchange membrane development, in terms of antifouling and their performance in desalination trials, achieved during the MIDES project, are reported.

Oil-in-water emulsions represent a promising carrier for in vivo imaging because of the possibility to convey poorly water-soluble species. To promote accumulation at the tumor site and prolong circulation time, reduction of carrier size and surface PEGylation plays a fundamental role. In this work a novel, simple method to design an oil-core/PEG-shell nanocarrier is reported. A PEG-shell is grown around a monodisperse oil-in-water nanoemulsion with a one-pot method, using the radical polymerization of poly(ethylene glycol)diacrylate. PEG polymerization is triggered by UV, obtaining a PEG-shell with tunable thickness. This core-shell nanosystem combines the eluding feature of the PEG with the ability to confine high payloads of lipophilic species. Indeed, the core is successfully loaded with a lipophilic contrast agent, namely super paramagnetic iron oxide nanocubes. Interestingly, it is demonstrated an in vitro and an in vivo MRI response of the nanocapsules. Additionally, when the nanosystem loaded with nanocubes is mixed with a fluorescent contrast agent, indo-cyanine green, a relevant in vitro photoacoustic effect is observed. Moreover, viability and cellular uptake studies show no significant cell cytotoxicity. These results, together with the choice of low cost materials and the scale up production, make this nanocarrier a potential platform for in vivo imaging.

The increased understanding of complex biological processes in cancer initiation and progression has proportionately increased new anticancer drug development which is presently the top priority research field. The process of drug discovery and development is expensive, tedious, and unpredictable. Several steps are involved in this process, which requires strong multidisciplinary interaction. The duration of the procedure depends upon the validation of each step. Current data shows that out of the 10,000 newly screened compounds, only 250 enter preclinical testing and 5 enter clinical phase. However, only one compound gets regulatory approval. The percentage of success in developing a drug is very low, in spite of huge time spent and financial investments. Therefore, it is utmost important to refine every step of the drug development process so as to precisely evaluate the new compounds. The process of drug development consists of various phases like absorption, distribution, metabolism and excretion. All these phases can be precisely studied using several advanced tools and one such tool is non-invasive preclinical imaging. This chapter deals with various preclinical imaging modalities having huge potential in anticancer drug discovery. The imaging modalities discussed in details are positron emission tomography (PET), single photon emission computed tomography (SPECT), computed tomography (CT), optical, ultrasound and photoacoustic (US-PA) and spectral imaging. These modalities are complimentary to each other and need to be applied on the basis of information to be gathered. The common study/imaging protocol used in anticancer drug development has been mentioned with appropriate image data. The modalities such as photoacoustic and spectral imaging have huge potential for clinical applications due to their potential to characterise tissue and underlying pathophysiological differences.

For the first time in atmospheric pressure-plasma enhanced chemical vapour deposition of amorphous silica onto flexible polymer substrates, pinholes have been visibly detected using interferometric microscopy and their average diameter of 1.7 μm calculated. Pinholes were found to control the water vapour transmission rate of all 30 nm films deposited with input energies greater than 9 keV per precursor molecule, thus presenting an opportunity for the synthesis of single layer thin films with precisely targeted permeation rates. The pinholes themselves were understood to originate from interactions between the polymer substrate and filaments in the plasma. The non-uniformity of the discharge was attributed to the reduced concentrations of precursor tetraethyl orthosilicate and oxygen species necessary to deposit amorphous silica at high specific energies.

New solutions for large bone defect repair are needed. Here, in situ gelling slow release systems for bone induction are assessed. Collagen-I based Recombinant Peptide (RCP) microspheres (MSs) are produced and used as a carrier for bone morphogenetic protein 2 (BMP-2). The RCP-MSs are dispersed in three hydrogels: high mannuronate (SLM) alginate, high guluronate (SLG) alginate, and thermoresponsive hyaluronan derivative (HApN). HApN+RCP-MS forms a gel structure at 32 ºC or above, while SLM+RCP-MS and SLG+RCP-MS respond to shear stress displaying thixotropic behavior. Alginate formulations show sustained release of BMP-2, while there is minimal release from HApN. These formulations are injected subcutaneously in rats. SLM+RCP-MS and SLG+RCP-MS loaded with BMP-2 induce ectopic bone formation as revealed by X-ray tomography and histology, whereas HApN+RCP-MS do not. Vascularization occurs within all the formulations studied and is significantly higher in SLG+MS and HApN+RCP-MS than in SLM+RCP-MS. Inflammation (based on macrophage subset staining) decreases over time in both alginate groups, but increases in the HApN+RCP-MS condition. It is shown that a balance between inflammatory cell infiltration, BMP-2 release, and vascularization, achieved in the SLG+RCP-MS alginate condition, is optimal for the induction of de novo bone formation.